Macular Edema (ME)

Also known as: MACULAR EDEMA / Edema, Macular / Macular oedema

DrugDrug NameDrug Description
DB08885AfliberceptAflibercept is a recombinant protein composed of the binding domains of two human vascular endothelial growth factor (VEGF) receptors fused with the Fc region of human immunoglobulin gamma 1 (IgG1). Structurally, Aflibercept is a dimeric glycoprotein with a protein molecular weight of 96.9 kilo Daltons (kDa). It contains approximately 15% glycosylation to give a total molecular weight of 115 kDa. All five putative N-glycosylation sites on each polypeptide chain predicted by the primary sequence can be occupied with carbohydrate and exhibit some degree of chain heterogeneity, including heterogeneity in terminal sialic acid residues, except at the single unsialylated site associated with the Fc domain. Aflibercept, as an ophthalmic agent, is used in the treatment of macular edema following Central Retinal Vein Occlusion (CRVO) and neovascular Age-Related Macular Degeneration (AMD). Ziv-aflibercept, under the brand name Zaltrap, was developed as an injection for treatment of metastatic colorectal cancer. FDA approved in November 18, 2011 and EMA approved in November 2012.
DB01234DexamethasoneAn anti-inflammatory 9-fluoro-glucocorticoid.
DB01270RanibizumabRanibizumab is a recombinant humanized IgG1 kappa isotype monoclonal antibody fragment designed for intraocular use. Ranibizumab binds to and inhibits the biologic activity of human vascular endothelial growth factor A (VEGF-A). Ranibizumab has a molecular weight of approximately 48 kilodaltons and is produced by an E. coli expression system in a nutrient medium containing the antibiotic tetracycline (tetracycline is not detectable in the final product). Ranibizumab is marketed under the name Lucentis®. It is indicated for the treatment of macular edema after retinal vein occlusion, age-related macular degeneration (wet), and diabetic macular edema.
DrugDrug NameTargetType
DB08885AfliberceptVascular endothelial growth factor Atarget
DB08885AfliberceptPlacenta growth factortarget
DB08885AfliberceptVascular endothelial growth factor Btarget
DB01234DexamethasoneGlucocorticoid receptortarget
DB01234DexamethasoneAnnexin A1target
DB01234DexamethasoneNitric oxide synthase, inducibletarget
DB01234DexamethasoneNuclear receptor subfamily 0 group B member 1target
DB01234DexamethasoneCytochrome P450 3A4enzyme
DB01234DexamethasoneCytochrome P450 3A5enzyme
DB01234DexamethasoneCytochrome P450 3A7enzyme
DB01234DexamethasoneBile salt export pumptransporter
DB01234DexamethasoneMultidrug resistance protein 1transporter
DB01234DexamethasoneCanalicular multispecific organic anion transporter 1transporter
DB01234DexamethasoneSolute carrier organic anion transporter family member 1A2transporter
DB01234DexamethasoneATP-binding cassette sub-family G member 2transporter
DB01234DexamethasoneCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DB01234DexamethasoneSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
DB01234DexamethasoneCytochrome P450 19A1enzyme
DB01234DexamethasoneCytochrome P450 1A1enzyme
DB01234DexamethasoneCytochrome P450 1B1enzyme
DB01234DexamethasoneCytochrome P450 2A6enzyme
DB01234DexamethasoneCytochrome P450 2B6enzyme
DB01234DexamethasoneCytochrome P450 2C19enzyme
DB01234DexamethasoneCytochrome P450 2C8enzyme
DB01234DexamethasoneCytochrome P450 2D6enzyme
DB01234DexamethasoneCytochrome P450 2E1enzyme
DB01234DexamethasoneCytochrome P450 3A43enzyme
DB01234DexamethasoneCytochrome P450 4A11enzyme
DB01234DexamethasoneNuclear receptor subfamily 1 group I member 2target
DB01270RanibizumabVascular endothelial growth factor Atarget
DrugDrug NamePhaseStatusCount
DB08885Aflibercept1Active Not Recruiting1
DB08885Aflibercept1Recruiting1
DB05311Ecallantide1Terminated1
DB00095Efalizumab1Completed1
DB00163Vitamin E1Completed2
DB01234Dexamethasone1 / 2Completed2
DB01234Dexamethasone1 / 2Terminated1
DB01270Ranibizumab1 / 2Completed2
DB06461Squalamine1 / 2Completed1
DB12258Abicipar Pegol2Completed1
DB00819Acetazolamide2Completed1
DB00112Bevacizumab2Completed3
DB00112Bevacizumab2Terminated1
DB00112Bevacizumab2Unknown Status1
DB00484Brimonidine2Completed1
DB01234Dexamethasone2Completed3
DB01234Dexamethasone2Terminated1
DB00591Fluocinolone acetonide2Terminated1
DB11075Hypromellose2Completed1
DB00465Ketorolac2Completed2
DB06802Nepafenac2Completed2
DB06802Nepafenac2Unknown Status1
DB11077Polyethylene glycol 4002Completed1
DB00860Prednisolone2Completed1
DB11078Propylene glycol2Completed1
DB01270Ranibizumab2Active Not Recruiting1
DB01270Ranibizumab2Completed4
DB01270Ranibizumab2Terminated1
DB01270Ranibizumab2Unknown Status2
DB01270Ranibizumab2Withdrawn1
DB00620Triamcinolone2Terminated1
DB00620Triamcinolone2Withdrawn1
DB00460Verteporfin2Completed1
DB00112Bevacizumab2 / 3Completed1
DB00112Bevacizumab2 / 3Unknown Status1
DB01234Dexamethasone2 / 3Completed1
DB00620Triamcinolone2 / 3Completed1
DB08885Aflibercept3Active Not Recruiting1
DB08885Aflibercept3Completed3
DB00112Bevacizumab3Completed2
DB11121Chloroxylenol3Terminated2
DB12460Conbercept3Recruiting2
DB01234Dexamethasone3Active Not Recruiting1
DB01234Dexamethasone3Completed4
DB01234Dexamethasone3Recruiting1
DB01234Dexamethasone3Unknown Status1
DB00563Methotrexate3Completed1
DB04895Pegaptanib3Completed1
DB01270Ranibizumab3Completed11
DB01270Ranibizumab3Recruiting1
DB00620Triamcinolone3Completed3
DB08885Aflibercept4Completed2
DB08885Aflibercept4Not Yet Recruiting1
DB08885Aflibercept4Recruiting1
DB00126Ascorbic acid4Not Yet Recruiting2
DB00112Bevacizumab4Completed1
DB00112Bevacizumab4Recruiting1
DB00112Bevacizumab4Unknown Status2
DB11136Chromium4Not Yet Recruiting2
DB01234Dexamethasone4Completed3
DB01234Dexamethasone4Not Yet Recruiting1
DB01234Dexamethasone4Recruiting2
DB06781Difluprednate4Recruiting1
DB00328Indometacin4Completed1
DB00465Ketorolac4Completed1
DB06757Manganese4Not Yet Recruiting2
DB00563Methotrexate4Terminated1
DB00968Methyldopa4Not Yet Recruiting2
DB06802Nepafenac4Completed1
DB06802Nepafenac4Recruiting1
DB00860Prednisolone4Recruiting1
DB01270Ranibizumab4Active Not Recruiting1
DB01270Ranibizumab4Completed4
DB01270Ranibizumab4Recruiting1
DB11135Selenium4Not Yet Recruiting2
DB00620Triamcinolone4Unknown Status1
DB01593Zinc4Not Yet Recruiting2
DB08885AfliberceptNot AvailableActive Not Recruiting1
DB08885AfliberceptNot AvailableCompleted1
DB08885AfliberceptNot AvailableRecruiting2
DB00112BevacizumabNot AvailableCompleted3
DB01234DexamethasoneNot AvailableCompleted10
DB01234DexamethasoneNot AvailableRecruiting2
DB01234DexamethasoneNot AvailableTerminated2
DB00586DiclofenacNot AvailableCompleted2
DB00465KetorolacNot AvailableCompleted1
DB01270RanibizumabNot AvailableCompleted5
DB01270RanibizumabNot AvailableUnknown Status2
DB01270RanibizumabNot AvailableWithdrawn1