Progressive Desmoids Tumors

Drug	Drug Name	Drug Description
DB12005	Nirogacestat	A gamma-secretase inhibitor used to treat desmoid tumors

Drug	Drug Name	Target	Type
DB12005	Nirogacestat	Presenilin-1	target
DB12005	Nirogacestat	Cytochrome P450 3A4	enzyme
DB12005	Nirogacestat	Cytochrome P450 2C9	enzyme
DB12005	Nirogacestat	Cytochrome P450 2C19	enzyme
DB12005	Nirogacestat	Cytochrome P450 2D6	enzyme
DB12005	Nirogacestat	Cytochrome P450 2B6	enzyme
DB12005	Nirogacestat	Serum albumin	carrier
DB12005	Nirogacestat	alpha1-acid glycoprotein	carrier
DB12005	Nirogacestat	P-glycoprotein 1	transporter
DB12005	Nirogacestat	Cytochrome P450 2C8	enzyme

Drug	Drug Name	Phase	Status	Count
DB00563	Methotrexate	2	Completed	1
DB06589	Pazopanib	2	Completed	1
DB00570	Vinblastine	2	Completed	1