Cardiovascular Outcomes

Also known as: Cardiovascular Outcome

DrugDrug NameDrug Description
DB00175PravastatinPravastatin is the 6-alpha-hydroxy acid form of [mevastatin].[T303] Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. It was the first statin administered as the active form and not as a prodrug.[T274] This drug was developed by Sankyo Co. Ltd.; however, the first approved pravastatin product was developed by Bristol Myers Squibb and FDA approved in 1991.[L6142] Pravastatin is made through a fermentation process in which [mevastatin] is first obtained. The manufacturing process is followed by the hydrolysis of the lactone group and the biological hydroxylation with _Streptomyces carbophilus_ to introduce the allylic 6-alcohol group.[T239]
DrugDrug NamePhaseStatusCount
DB11121Chloroxylenol4Completed1
DB00091Ciclosporin4Withdrawn1
DB00688Mycophenolate mofetil4Withdrawn1
DB01024Mycophenolic acid4Withdrawn1
DB00627Niacin4Completed1
DB00635Prednisone4Withdrawn1