Actinic Keratosis (AK)

Also known as: Solar keratosis / Actinic keratosis / Actinic Keratoses / Keratosis, Actinic / Senile keratoma / Senile keratosis / Keratosis NOS

DrugDrug NameDrug Description
DB00586DiclofenacAn NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis.
DB00544FluorouracilA pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment.
DB05013Ingenol mebutateA topical agent used for the treatment of actinic keratosis.
DB00992Methyl aminolevulinateA porphyrin precursor used to treat non-hyperkeratotic, non-pigmented actinic keratosis of the face and scalp.
DB00936Salicylic acidAn acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts.
DrugDrug NameTargetType
DB00586DiclofenacProstaglandin G/H synthase 1target
DB00586DiclofenacProstaglandin G/H synthase 2target
DB00586DiclofenacTransthyretincarrier
DB00586DiclofenacCytochrome P450 2C9enzyme
DB00586DiclofenacCytochrome P450 2C19enzyme
DB00586DiclofenacCytochrome P450 1A2enzyme
DB00586DiclofenacCytochrome P450 2C8enzyme
DB00586DiclofenacSerum albumincarrier
DB00586DiclofenacMultidrug resistance-associated protein 4transporter
DB00586DiclofenacMultidrug resistance-associated protein 1transporter
DB00586DiclofenacSolute carrier family 22 member 6transporter
DB00586DiclofenacSolute carrier family 22 member 8transporter
DB00586DiclofenacSolute carrier organic anion transporter family member 1C1transporter
DB00586DiclofenacSolute carrier family 22 member 11transporter
DB00586DiclofenacUDP-glucuronosyltransferase 2B7enzyme
DB00586DiclofenacCytochrome P450 3A4enzyme
DB00586DiclofenacCytochrome P450 2B6enzyme
DB00586DiclofenacCytochrome P450 2C18enzyme
DB00586DiclofenacCytochrome P450 2E1enzyme
DB00586DiclofenacSolute carrier organic anion transporter family member 1B1transporter
DB00586DiclofenacBile salt export pumptransporter
DB00586DiclofenacUDP-glucuronosyltransferase 1-3enzyme
DB00586DiclofenacUDP-glucuronosyltransferase 1-9enzyme
DB00586DiclofenacUDP-glucuronosyltransferase 2B4enzyme
DB00586DiclofenacArachidonate 5-lipoxygenaseenzyme
DB00586DiclofenacSodium channel protein type 4 subunit alphatransporter
DB00586DiclofenacAcid-sensing ion channel 1transporter
DB00586DiclofenacPotassium voltage-gated channel subfamily KQT member 2transporter
DB00586DiclofenacPotassium voltage-gated channel subfamily KQT member 3transporter
DB00586DiclofenacPhospholipase A2, membrane associatedenzyme
DB00544FluorouracilThymidylate synthasetarget
DB00544FluorouracilCytochrome P450 1A2enzyme
DB00544FluorouracilThymidine phosphorylaseenzyme
DB00544FluorouracilSerum albumincarrier
DB00544FluorouracilCytochrome P450 2C9enzyme
DB00544FluorouracilDihydropyrimidine dehydrogenase [NADP(+)]enzyme
DB00544FluorouracilUridine phosphorylase 1enzyme
DB00544FluorouracilUridine phosphorylase 2enzyme
DB00544FluorouracilDNAtarget
DB00544FluorouracilRNAtarget
DB00544FluorouracilCytochrome P450 2A6enzyme
DB00544FluorouracilCytochrome P450 2C8enzyme
DB00544FluorouracilMethylenetetrahydrofolate reductaseenzyme
DB00544FluorouracilThymidylate synthaseenzyme
DB00544FluorouracilUridine 5'-monophosphate synthaseenzyme
DB00544FluorouracilAmidophosphoribosyltransferaseenzyme
DB00544FluorouracilSolute carrier family 22 member 7transporter
DB00544FluorouracilEquilibrative nucleoside transporter 1transporter
DB00544FluorouracilATP-binding cassette sub-family G member 2transporter
DB00544FluorouracilCanalicular multispecific organic anion transporter 2transporter
DB00544FluorouracilMultidrug resistance-associated protein 4transporter
DB00544FluorouracilMultidrug resistance-associated protein 5transporter
DB00544FluorouracilThyroxine-binding globulincarrier
DB05013Ingenol mebutateProtein kinase C delta typetarget
DB05013Ingenol mebutateProtein kinase C alpha typetarget
DB00992Methyl aminolevulinateHigh affinity immunoglobulin gamma Fc receptor Itarget
DB00936Salicylic acidSerum albumincarrier
DB00936Salicylic acidProstaglandin G/H synthase 1target
DB00936Salicylic acidProstaglandin G/H synthase 2target
DB00936Salicylic acidAldo-keto reductase family 1 member C1target
DB00936Salicylic acidSolute carrier family 22 member 6transporter
DB00936Salicylic acidSolute carrier family 22 member 10transporter
DB00936Salicylic acidSolute carrier family 22 member 8transporter
DB00936Salicylic acidSolute carrier family 22 member 11transporter
DB00936Salicylic acidSolute carrier organic anion transporter family member 2B1transporter
DB00936Salicylic acidMonocarboxylate transporter 1transporter
DB00936Salicylic acidSolute carrier family 22 member 7transporter
DB00936Salicylic acidCytochrome P450 2C9enzyme
DrugDrug NamePhaseStatusCount
DB02300Calcipotriol0Completed1
DB02300Calcipotriol0Not Yet Recruiting1
DB00544Fluorouracil0Completed1
DB00544Fluorouracil0Not Yet Recruiting1
DB05013Ingenol mebutate0Withdrawn1
DB00855Aminolevulinic acid1Completed1
DB00482Celecoxib1Recruiting1
DB00586Diclofenac1Completed1
DB00724Imiquimod1Completed2
DB15109Ingenol disoxate1Completed3
DB05013Ingenol mebutate1Completed11
DB06137KX-011Completed1
DB06137KX-011Recruiting1
DB00281Lidocaine1Completed1
DB00750Prilocaine1Completed1
DB12700Solamargine1Completed1
DB00855Aminolevulinic acid1 / 2Terminated1
DB06261Hexaminolevulinate1 / 2Completed1
DB15109Ingenol disoxate1 / 2Completed3
DB05013Ingenol mebutate1 / 2Completed2
DB00992Methyl aminolevulinate1 / 2Completed1
DB04931Afamelanotide2Unknown Status1
DB00855Aminolevulinic acid2Completed7
DB00855Aminolevulinic acid2Terminated1
DB09096Benzoyl peroxide2Completed1
DB00169Cholecalciferol2Not Yet Recruiting1
DB00390Digoxin2Recruiting1
DB00695Furosemide2Recruiting1
DB00724Imiquimod2Completed4
DB15109Ingenol disoxate2Completed1
DB05013Ingenol mebutate2Active Not Recruiting1
DB05013Ingenol mebutate2Completed7
DB00982Isotretinoin2Completed1
DB06137KX-012Completed1
DB01229Paclitaxel2Completed1
DB06530Resiquimod2Completed1
DB00755Tretinoin2Completed1
DB00855Aminolevulinic acid3Completed6
DB00855Aminolevulinic acid3Withdrawn1
DB00586Diclofenac3Completed4
DB00544Fluorouracil3Completed4
DB00544Fluorouracil3Recruiting1
DB00544Fluorouracil3Terminated1
DB00724Imiquimod3Completed10
DB15109Ingenol disoxate3Completed4
DB15109Ingenol disoxate3Terminated1
DB05013Ingenol mebutate3Completed13
DB05013Ingenol mebutate3Terminated1
DB06137KX-013Completed2
DB00992Methyl aminolevulinate3Completed5
DB09152Nitrogen3Completed1
DB00936Salicylic acid3Completed1
DB08604Triclosan3Completed1
DB00855Aminolevulinic acid4Completed3
DB00855Aminolevulinic acid4Not Yet Recruiting1
DB00855Aminolevulinic acid4Recruiting2
DB00855Aminolevulinic acid4Terminated1
DB00586Diclofenac4Completed4
DB00544Fluorouracil4Active Not Recruiting1
DB00544Fluorouracil4Completed2
DB08818Hyaluronic acid4Completed1
DB00724Imiquimod4Active Not Recruiting1
DB00724Imiquimod4Completed5
DB00724Imiquimod4Terminated2
DB00724Imiquimod4Unknown Status2
DB05013Ingenol mebutate4Active Not Recruiting2
DB05013Ingenol mebutate4Completed5
DB00825Levomenthol4Recruiting1
DB00992Methyl aminolevulinate4Completed2
DB00855Aminolevulinic acidNot AvailableCompleted3
DB00855Aminolevulinic acidNot AvailableNot Yet Recruiting1
DB00855Aminolevulinic acidNot AvailableWithdrawn1
DB00341CetirizineNot AvailableCompleted1
DB00586DiclofenacNot AvailableCompleted1
DB00544FluorouracilNot AvailableCompleted2
DB00544FluorouracilNot AvailableWithdrawn1
DB00724ImiquimodNot AvailableCompleted2
DB00724ImiquimodNot AvailableWithdrawn1
DB05013Ingenol mebutateNot AvailableCompleted5
DB05013Ingenol mebutateNot AvailableUnknown Status1
DB00992Methyl aminolevulinateNot AvailableRecruiting1
DB00799TazaroteneNot AvailableCompleted1