Lung Transplant Rejection

Also known as: Lung transplant rejection

DrugDrug NameDrug Description
DB09312Antilymphocyte immunoglobulin (horse)Equine anti-thymocyte globulin is composed of purified gamma globulin containing primarily IgG against human thymus lymphocytes. It is formed by inoculating a horse with an antigen (human thymoyctes) which then induces the horse immune system's B-lymphocytes to produce IgG immunoglobulins specific for that antigen. The result is polyclonal IgG that is then purified from the horse's serum to produce a usable drug product that can be used for immunosuppression. Although the exact mechanism of action is unknown, equine anti-thymocyte globulin targets a variety of immune system proteins including lymphocyte surface proteins, granulocytes, platelets, bone marrow cells, and other cell types. Equine ATG is currently indicated for the suppression of the immune system to prevent renal transplant rejection and in the treatment of aplastic anemia. Induction of T cell apoptosis and resulting T-cell lymphopenia found in vivo is credited for its therapeutic effect in these conditions. There are currently various ATG products available, which differ in the source of inoculated animal (rabbit, horse, or pig) and in the type of antigen product used to produce immunoglobulin (thymocytes, peripheral T cells, etc.).
DB00877SirolimusA macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to immunophilins. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
DrugDrug NamePhaseStatusCount
DB00098Antithymocyte immunoglobulin (rabbit)2Not Yet Recruiting1
DB06681Belatacept2Not Yet Recruiting1
DB06681Belatacept2Withdrawn1
DB08889Carfilzomib2Recruiting1
DB08889Carfilzomib2Withdrawn1
DB00959Methylprednisolone2Not Yet Recruiting1
DB00688Mycophenolate mofetil2Not Yet Recruiting1
DB01024Mycophenolic acid2Not Yet Recruiting1
DB04951Pirfenidone2Recruiting1
DB00635Prednisone2Not Yet Recruiting1
DB00864Tacrolimus2Not Yet Recruiting1
DB08932Macitentan4Not Yet Recruiting1