Sarcoma, Osteogenic

Also known as: Osteosarcoma / Osteogenic Sarcoma / Osteosarcomas / Sarcoma osteogenic / Osteosarcoma NOS

DrugDrug NameDrug Description
DB00515CisplatinCisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes carboplatin and oxaliplatin.
DB00970DactinomycinA compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
DB00773EtoposideA semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. [PubChem]
DB01181IfosfamideIfosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppresive agent.
DB00563MethotrexateAn antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate dehydrogenase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
DrugDrug NameTargetType
DB00515CisplatinDNAtarget
DB00515CisplatinCanalicular multispecific organic anion transporter 2transporter
DB00515CisplatinMultidrug resistance-associated protein 5transporter
DB00515CisplatinCanalicular multispecific organic anion transporter 1transporter
DB00515CisplatinSolute carrier family 22 member 2transporter
DB00515CisplatinHigh affinity copper uptake protein 1transporter
DB00515CisplatinProbable low affinity copper uptake protein 2transporter
DB00515CisplatinMultidrug resistance-associated protein 6transporter
DB00515CisplatinMultidrug resistance protein 1transporter
DB00515CisplatinCopper-transporting ATPase 2transporter
DB00515CisplatinCopper-transporting ATPase 1transporter
DB00515CisplatinProstaglandin G/H synthase 2enzyme
DB00515CisplatinMyeloperoxidaseenzyme
DB00515CisplatinXanthine dehydrogenase/oxidaseenzyme
DB00515CisplatinArylamine N-acetyltransferaseenzyme
DB00515CisplatinCytochrome P450 2C9enzyme
DB00515CisplatinCytochrome P450 2B6enzyme
DB00515CisplatinCholinesteraseenzyme
DB00515CisplatinCytochrome P450 4A11enzyme
DB00515CisplatinATP-binding cassette sub-family G member 2transporter
DB00515CisplatinGlutathione S-transferase theta-1enzyme
DB00515CisplatinMetallothionein-1Aenzyme
DB00515CisplatinMetallothionein-2enzyme
DB00515CisplatinSuperoxide dismutase [Cu-Zn]enzyme
DB00515CisplatinGlutathione S-transferase Penzyme
DB00515CisplatinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00515CisplatinGlutathione S-transferase Mu 1enzyme
DB00515CisplatinDNA-3-methyladenine glycosylasetarget
DB00515CisplatinAlpha-2-macroglobulintarget
DB00515CisplatinSerum albumincarrier
DB00515CisplatinSerotransferrintarget
DB00515CisplatinCopper transport protein ATOX1target
DB00970DactinomycinDNAtarget
DB00970DactinomycinSolute carrier family 22 member 5transporter
DB00970DactinomycinMultidrug resistance protein 1transporter
DB00970DactinomycinMultidrug resistance-associated protein 6transporter
DB00970DactinomycinMultidrug resistance-associated protein 1transporter
DB00970DactinomycinATP-binding cassette sub-family G member 2transporter
DB00970DactinomycinDNA topoisomerase 2target
DB00773EtoposideDNA topoisomerase 2-alphatarget
DB00773EtoposideCytochrome P450 3A4enzyme
DB00773EtoposideCanalicular multispecific organic anion transporter 2transporter
DB00773EtoposideMultidrug resistance-associated protein 6transporter
DB00773EtoposideMultidrug resistance protein 1transporter
DB00773EtoposideMultidrug resistance-associated protein 1transporter
DB00773EtoposideMultidrug resistance-associated protein 7transporter
DB00773EtoposideCanalicular multispecific organic anion transporter 1transporter
DB00773EtoposideATP-binding cassette sub-family G member 2transporter
DB00773EtoposideCytochrome P450 1A2enzyme
DB00773EtoposideCytochrome P450 2C8enzyme
DB00773EtoposideCytochrome P450 2E1enzyme
DB00773EtoposideCytochrome P450 3A5enzyme
DB00773EtoposideUDP-glucuronosyltransferase 1-1enzyme
DB00773EtoposideDNA topoisomerase 2-betatarget
DB00773EtoposideGlutathione S-transferase theta-1enzyme
DB00773EtoposideGlutathione S-transferase Penzyme
DB00773EtoposideProstaglandin G/H synthase 2enzyme
DB00773EtoposideProstaglandin G/H synthase 1enzyme
DB01181IfosfamideCytochrome P450 2B6enzyme
DB01181IfosfamideDNAtarget
DB01181IfosfamideCytochrome P450 3A4enzyme
DB01181IfosfamideCytochrome P450 3A5enzyme
DB01181IfosfamideCytochrome P450 2C9enzyme
DB01181IfosfamideCytochrome P450 2C8enzyme
DB01181IfosfamideCytochrome P450 2A6enzyme
DB01181IfosfamideCytochrome P450 2C19enzyme
DB01181IfosfamideCytochrome P450 2C18enzyme
DB01181IfosfamideProstaglandin G/H synthase 1enzyme
DB01181IfosfamideCytochrome P450 3A7enzyme
DB01181IfosfamideNuclear receptor subfamily 1 group I member 2target
DB00563MethotrexateDihydrofolate reductasetarget
DB00563MethotrexateAldehyde oxidaseenzyme
DB00563MethotrexateMethylenetetrahydrofolate reductaseenzyme
DB00563MethotrexateSerum albumincarrier
DB00563MethotrexateCanalicular multispecific organic anion transporter 2transporter
DB00563MethotrexateMultidrug resistance-associated protein 4transporter
DB00563MethotrexateMultidrug resistance-associated protein 1transporter
DB00563MethotrexateSolute carrier family 22 member 6transporter
DB00563MethotrexateMultidrug resistance-associated protein 7transporter
DB00563MethotrexateSolute carrier family 22 member 8transporter
DB00563MethotrexateCanalicular multispecific organic anion transporter 1transporter
DB00563MethotrexateMultidrug resistance protein 1transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1A2transporter
DB00563MethotrexateMonocarboxylate transporter 1transporter
DB00563MethotrexateATP-binding cassette sub-family C member 11transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1B3transporter
DB00563MethotrexateSolute carrier family 22 member 11transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1C1transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 3A1transporter
DB00563MethotrexateATP-binding cassette sub-family G member 2transporter
DB00563MethotrexateSolute carrier family 22 member 7transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1B1transporter
DB00563Methotrexate6-phosphogluconate dehydrogenase, decarboxylatingenzyme
DB00563MethotrexateProton-coupled folate transportertransporter
DB00563MethotrexateFolylpolyglutamate synthase, mitochondrialenzyme
DB00563MethotrexateGamma-glutamyl hydrolaseenzyme
DB00563MethotrexateDihydrofolate reductaseenzyme
DB00563MethotrexateThymidylate synthaseenzyme
DB00563MethotrexateBifunctional purine biosynthesis protein PURHenzyme
DB00563MethotrexateSolute carrier organic anion transporter family member 4C1transporter
DB00563MethotrexateFolate transporter 1transporter
DB00563MethotrexateFolate receptor alphatransporter
DrugDrug NamePhaseStatusCount
DB00531Cyclophosphamide0Recruiting1
DB01041Thalidomide0Recruiting1
DB04974AP19031Completed1
DB06151Acetylcysteine1Recruiting1
DB00928Azacitidine1Recruiting1
DB00515Cisplatin1Terminated1
DB09110Coenzyme M1Terminated1
DB00531Cyclophosphamide1Completed1
DB00531Cyclophosphamide1Recruiting2
DB01234Dexamethasone1Withdrawn1
DB00380Dexrazoxane1Terminated1
DB00997Doxorubicin1Completed1
DB00997Doxorubicin1Recruiting1
DB05847Doxorubicin1Recruiting1
DB00997Doxorubicin1Terminated1
DB06210Eltrombopag1Terminated1
DB00773Etoposide1Terminated1
DB01181Ifosfamide1Terminated1
DB00762Irinotecan1Completed1
DB00650Leucovorin1Terminated1
DB06589Pazopanib1Withdrawn1
DB00019Pegfilgrastim1Terminated1
DB11870RG-47331Withdrawn1
DB00641Simvastatin1Recruiting1
DB00877Sirolimus1Active Not Recruiting1
DB00398Sorafenib1Completed1
DB00675Tamoxifen1Completed1
DB01030Topotecan1Recruiting1
DB00541Vincristine1Completed1
DB00399Zoledronic acid1Recruiting1
DB00041Aldesleukin1 / 2Active Not Recruiting1
DB00773Etoposide1 / 2Recruiting1
DB01181Ifosfamide1 / 2Recruiting1
DB09078Lenvatinib1 / 2Recruiting1
DB00650Leucovorin1 / 2Completed1
DB12676Modufolin1 / 2Completed1
DB09035Nivolumab1 / 2Not Yet Recruiting1
DB01229Paclitaxel1 / 2Active Not Recruiting1
DB11945Avelumab2Recruiting1
DB00112Bevacizumab2Active Not Recruiting1
DB00958Carboplatin2Completed1
DB00515Cisplatin2Active Not Recruiting1
DB00515Cisplatin2Completed1
DB00531Cyclophosphamide2Completed1
DB00531Cyclophosphamide2Recruiting1
DB01248Docetaxel2Recruiting1
DB00997Doxorubicin2Active Not Recruiting1
DB00997Doxorubicin2Completed2
DB11727Endostar2Unknown Status1
DB00530Erlotinib2Recruiting1
DB00773Etoposide2Active Not Recruiting1
DB00773Etoposide2Completed1
DB00441Gemcitabine2Recruiting2
DB08898Glucarpidase2Terminated2
DB01181Ifosfamide2Active Not Recruiting1
DB01181Ifosfamide2Completed2
DB01181Ifosfamide2Recruiting1
DB06186Ipilimumab2Not Yet Recruiting1
DB00134L-Methionine2Recruiting1
DB00650Leucovorin2Terminated2
DB00563Methotrexate2Active Not Recruiting1
DB00563Methotrexate2Completed1
DB00563Methotrexate2Recruiting1
DB00563Methotrexate2Terminated1
DB05258Natural alpha interferon2Completed1
DB09035Nivolumab2Not Yet Recruiting1
DB01229Paclitaxel2Recruiting1
DB00213Pantoprazole2Active Not Recruiting1
DB06589Pazopanib2Active Not Recruiting1
DB09037Pembrolizumab2Recruiting1
DB00642Pemetrexed2Completed2
DB08896Regorafenib2Recruiting2
DB12976Robatumumab2Terminated1
DB11805Saracatinib2Active Not Recruiting1
DB00877Sirolimus2Completed1
DB00398Sorafenib2Completed1
DB00853Temozolomide2Recruiting1
DB04572Thiotepa2Active Not Recruiting1
DB08881Vemurafenib2Recruiting1
DB00361Vinorelbine2Unknown Status1
DB00997Doxorubicin2 / 3Recruiting1
DB00997Doxorubicin2 / 3Unknown Status1
DB01181Ifosfamide2 / 3Recruiting1
DB01181Ifosfamide2 / 3Unknown Status1
DB00563Methotrexate2 / 3Recruiting1
DB00399Zoledronic acid2 / 3Unknown Status1
DB00997Doxorubicin3Completed1
DB00773Etoposide3Completed1
DB00099Filgrastim3Active Not Recruiting1
DB01181Ifosfamide3Completed1
DB00563Methotrexate3Completed2
DB01356Lithium4Recruiting1
DB00958CarboplatinNot AvailableTerminated1
DB00515CisplatinNot AvailableCompleted1
DB00515CisplatinNot AvailableTerminated1
DB09110Coenzyme MNot AvailableTerminated1
DB00380DexrazoxaneNot AvailableTerminated1
DB00997DoxorubicinNot AvailableCompleted1
DB00997DoxorubicinNot AvailableTerminated1
DB06215FerumoxytolNot AvailableRecruiting1
DB00441GemcitabineNot AvailableTerminated1
DB01181IfosfamideNot AvailableCompleted1
DB01181IfosfamideNot AvailableTerminated1
DB00650LeucovorinNot AvailableTerminated1
DB00650LeucovorinNot AvailableUnknown Status1
DB00563MethotrexateNot AvailableCompleted2
DB00563MethotrexateNot AvailableTerminated1
DB00563MethotrexateNot AvailableUnknown Status1
DB00020SargramostimNot AvailableTerminated1