Atopic Dermatitis (AD)

Also known as: Atopic Dermatitis / Dermatitis, Atopic / Dermatitis allergic / Atopic Eczema / Eczema, Atopic / Dermatitides, Atopic / Atopic dermatitis, unspecified / Allergic (intrinsic) eczema / Eczema allergic / Allergic dermatitis / Eczema atopic / Allergic eczema / Dermatitis atopic

DrugDrug NameDrug Description
DB13906Aloe PolysaccharideAloe describes a genus including over 500 species of flowering succulent plants that grow in the Southern peninsula and various islands. Aloe vera, or _Aloe barbadensis miller_, is the most common species of Aloe that is cultivated for agricultural and medical purposes. It is a perennial succulent xerophyte with elongated leaves that contain a clear gel. While aloe vera has a long history of commercial uses, it is still widely used in cosmetic, food and pharmaceutical products. The use of aloe vera in constipation, inflammatory disorders, cancer, ulcer, and diabetes has also been investigated [A32476]. The active constituents of aloe vera include polysaccharides with protective effects on skin, as they exhibit antioxidant and anti-inflammatory properties [A32481]. Common active polysaccharides include glucomannans, polymannose, and acemannan, or b-(1–4)-acetylated polymannose [A32475]. Acemannan and other modified polysaccharides are responsible in preventing suppression of contact hypersensitivity or immune suppression induced by external factors such as irradiation [A32473].
DB04815ClioquinolClioquinol was withdrawn in 1983 due to neurotoxicity.
DB01380Cortisone acetateCortisone acetate is a steroid hormone that has both glucocoriticoid and mineral corticoid activities. Corticosteroids are used to provide relief for inflamed areas of the body. They lessen swelling, redness, itching, and allergic reactions. They are often used as part of the treatment for a number of different diseases, such as severe allergies or skin problems, asthma, or arthritis. Endogenous glucocorticoids and some synthetic corticoids have high affinity to the protein transcortin (also called CBG, corticosteroid-binding protein), whereas all of them bind albumin. Glucocorticoids also bind to the cytosolic glucocorticoid receptor.
DB01234DexamethasoneAn anti-inflammatory 9-fluoro-glucocorticoid. [PubChem]
DB01142DoxepinDoxepin is a dibenzoxepin-derivative tricyclic antidepressant (TCA). Structurally similar to phenothiazines, TCAs contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, doxepin does not affect mood or arousal, but may cause sedation. In depressed individuals, doxepin exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as doxepin and amitriptyline, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and desipramine. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H1 receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. Doxepin has less sedative and anticholinergic effects than amitriptyline. See toxicity section below for a complete listing of side effects. When orally administered, doxepin may be used to treat depression and insomnia. Unlabeled indications of oral doxepin also include chronic and neuropathic pain, and anxiety. Doxepin may also be used as a second line agent to treat idiopathic urticaria. As a topical agent, doxepin may be used relieve itching in patients with certain types of eczema. It may be used for the management of moderate pruritus in adult patients with atopic dermatitis or lichen simplex chronicus.
DB00591Fluocinolone AcetonideA glucocorticoid derivative used topically in the treatment of various skin disorders. It is usually employed as a cream, gel, lotion, or ointment. It has also been used topically in the treatment of inflammatory eye, ear, and nose disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p732). It is also being investigated by Sivida and Alimera, under the brand name Medidur, as a sustained release intraocular implant for the treatment of diabetic macular edema.
DB00741HydrocortisoneThe main glucocorticoid secreted by the adrenal cortex. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. [PubChem]
DB00959MethylprednisoloneA prednisolone derivative with similar anti-inflammatory action. [PubChem]
DB00860PrednisoloneA glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states. [PubChem]
DB00635PrednisoneA synthetic anti-inflammatory glucocorticoid derived from cortisone. It is biologically inert and converted to prednisolone in the liver. [PubChem]
DB00620TriamcinoloneA glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739)
DrugDrug NameTargetType
DB13906Aloe PolysaccharideFree radicalstarget
DB01380Cortisone acetateGlucocorticoid receptortarget
DB01380Cortisone acetateCytochrome P450 3A4enzyme
DB01234DexamethasoneGlucocorticoid receptortarget
DB01234DexamethasoneAnnexin A1target
DB01234DexamethasoneNitric oxide synthase, inducibletarget
DB01234DexamethasoneNuclear receptor subfamily 0 group B member 1target
DB01234DexamethasoneCytochrome P450 3A4enzyme
DB01234DexamethasoneCytochrome P450 2C9enzyme
DB01234DexamethasoneCytochrome P450 3A5enzyme
DB01234DexamethasoneCytochrome P450 3A7enzyme
DB01234DexamethasoneBile salt export pumptransporter
DB01234DexamethasoneMultidrug resistance protein 1transporter
DB01234DexamethasoneCanalicular multispecific organic anion transporter 1transporter
DB01234DexamethasoneSolute carrier organic anion transporter family member 1A2transporter
DB01234DexamethasoneATP-binding cassette sub-family G member 2transporter
DB01234DexamethasoneCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DB01234DexamethasoneSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
DB01234DexamethasoneCytochrome P450 19A1enzyme
DB01234DexamethasoneCytochrome P450 1A1enzyme
DB01234DexamethasoneCytochrome P450 1B1enzyme
DB01234DexamethasoneCytochrome P450 2A6enzyme
DB01234DexamethasoneCytochrome P450 2B6enzyme
DB01234DexamethasoneCytochrome P450 2C19enzyme
DB01234DexamethasoneCytochrome P450 2C8enzyme
DB01234DexamethasoneCytochrome P450 2D6enzyme
DB01234DexamethasoneCytochrome P450 2E1enzyme
DB01234DexamethasoneCytochrome P450 3A43enzyme
DB01234DexamethasoneCytochrome P450 4A11enzyme
DB01234DexamethasoneNuclear receptor subfamily 1 group I member 2target
DB01142DoxepinSodium-dependent serotonin transportertarget
DB01142DoxepinSodium-dependent noradrenaline transportertarget
DB01142DoxepinHistamine H1 receptortarget
DB01142DoxepinHistamine H2 receptortarget
DB01142DoxepinCytochrome P450 2D6enzyme
DB01142DoxepinMuscarinic acetylcholine receptor M1target
DB01142DoxepinMuscarinic acetylcholine receptor M2target
DB01142DoxepinMuscarinic acetylcholine receptor M3target
DB01142DoxepinMuscarinic acetylcholine receptor M4target
DB01142DoxepinMuscarinic acetylcholine receptor M5target
DB01142DoxepinAlpha-1A adrenergic receptortarget
DB01142Doxepin5-hydroxytryptamine receptor 1Atarget
DB01142Doxepin5-hydroxytryptamine receptor 2Atarget
DB01142DoxepinD(2) dopamine receptortarget
DB01142DoxepinCytochrome P450 2C19enzyme
DB01142DoxepinCytochrome P450 2C9enzyme
DB01142DoxepinCytochrome P450 1A2enzyme
DB01142DoxepinAlpha-1-acid glycoprotein 1carrier
DB01142DoxepinMultidrug resistance protein 1transporter
DB01142Doxepin5-hydroxytryptamine receptor 2Btarget
DB01142Doxepin5-hydroxytryptamine receptor 2Ctarget
DB01142DoxepinAlpha-1B adrenergic receptortarget
DB01142DoxepinAlpha-1D adrenergic receptortarget
DB01142DoxepinAlpha-2A adrenergic receptortarget
DB01142DoxepinAlpha-2B adrenergic receptortarget
DB01142DoxepinAlpha-2C adrenergic receptortarget
DB01142DoxepinCytochrome P450 3A4enzyme
DB01142Doxepin5-hydroxytryptamine receptor 6target
DB01142DoxepinHistamine H4 receptortarget
DB01142DoxepinPotassium voltage-gated channel subfamily H member 2target
DB00591Fluocinolone AcetonideCorticosteroid-binding globulincarrier
DB00591Fluocinolone AcetonideGlucocorticoid receptortarget
DB00591Fluocinolone AcetonideCytosolic phospholipase A2enzyme
DB00741HydrocortisoneAnnexin A1target
DB00741HydrocortisoneGlucocorticoid receptortarget
DB00741HydrocortisoneSex hormone-binding globulincarrier
DB00741HydrocortisoneCytochrome P450 3A4enzyme
DB00741HydrocortisoneCytochrome P450 3A5enzyme
DB00741HydrocortisoneCytochrome P450 3A7enzyme
DB00741HydrocortisoneMultidrug resistance protein 1transporter
DB00741HydrocortisoneSolute carrier organic anion transporter family member 1A2transporter
DB00741HydrocortisoneATP-binding cassette sub-family G member 2transporter
DB00741HydrocortisoneCytochrome P450 11B1, mitochondrialenzyme
DB00741HydrocortisoneCytochrome P450 11B2, mitochondrialenzyme
DB00741HydrocortisoneCytochrome P450 2C8enzyme
DB00741HydrocortisoneCorticosteroid-binding globulincarrier
DB00741HydrocortisoneCorticosteroid 11-beta-dehydrogenase isozyme 2target
DB00741Hydrocortisone3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
DB00741HydrocortisoneSolute carrier family 22 member 8transporter
DB00959MethylprednisoloneGlucocorticoid receptortarget
DB00959MethylprednisoloneCytochrome P450 3A4enzyme
DB00959MethylprednisoloneMultidrug resistance protein 1transporter
DB00860PrednisoloneCorticosteroid-binding globulincarrier
DB00860PrednisoloneCytochrome P450 3A4enzyme
DB00860PrednisoloneGlucocorticoid receptortarget
DB00860PrednisoloneSolute carrier organic anion transporter family member 1A2transporter
DB00860PrednisoloneMultidrug resistance protein 1transporter
DB00860PrednisoloneCytochrome P450 2A6enzyme
DB00635PrednisoneGlucocorticoid receptortarget
DB00635PrednisoneCytochrome P450 3A4enzyme
DB00635PrednisoneMultidrug resistance protein 1transporter
DB00635PrednisoneSolute carrier organic anion transporter family member 1A2transporter
DB00635PrednisoneCytochrome P450 2C19enzyme
DB00635PrednisoneSerum albumincarrier
DB00635PrednisoneCorticosteroid 11-beta-dehydrogenase isozyme 1target
DB00620TriamcinoloneCorticosteroid-binding globulincarrier
DB00620TriamcinoloneGlucocorticoid receptortarget
DB00620TriamcinoloneCytochrome P450 3A4enzyme
DB00620TriamcinoloneProstaglandin G/H synthase 2enzyme
DB00620TriamcinoloneCholinesteraseenzyme
DrugDrug NamePhaseStatusCount
DB00026Anakinra1Terminated1
DB00443Betamethasone1Completed1
DB00201Caffeine1Completed1
DB00201Caffeine1Not Yet Recruiting1
DB01013Clobetasol propionate1Completed2
DB12159Dupilumab1Active Not Recruiting1
DB12159Dupilumab1Completed1
DB00095Efalizumab1Completed1
DB12322GW-8700861Completed1
DB11123Hypochlorite1Withdrawn1
DB00264Metoprolol1Completed1
DB00264Metoprolol1Not Yet Recruiting1
DB00683Midazolam1Completed1
DB00683Midazolam1Not Yet Recruiting1
DB00764Mometasone1Completed1
DB00540Nortriptyline1Completed1
DB00043Omalizumab1Completed2
DB00338Omeprazole1Completed1
DB00338Omeprazole1Not Yet Recruiting1
DB00337Pimecrolimus1Completed2
DB13973Remestemcel-L1Completed1
DB00864Tacrolimus1Completed1
DB06083Tapinarof1Completed2
DB12169Tralokinumab1Not Yet Recruiting1
DB00682Warfarin1Completed1
DB00682Warfarin1Not Yet Recruiting1
DB12159Dupilumab1 / 2Completed1
DB12776E-60051 / 2Completed2
DB02929K2011 / 2Completed1
DB12428PAC-140281 / 2Recruiting1
DB06083Tapinarof1 / 2Completed1
DB13012AQX-11252Completed1
DB00092Alefacept2Completed1
DB05676Apremilast2Completed1
DB05104Asimadoline2Completed1
DB09495Avobenzone2Unknown Status1
DB11817Baricitinib2Completed1
DB02300Calcipotriol2Completed1
DB00567Cephalexin2Recruiting1
DB00169Cholecalciferol2Completed1
DB00169Cholecalciferol2Recruiting1
DB00091Cyclosporine2Completed1
DB00154Dihomo-gamma-linolenic acid2Completed1
DB00254Doxycycline2Recruiting1
DB12159Dupilumab2Completed6
DB12776E-60052Completed1
DB00095Efalizumab2Completed1
DB12011Fevipiprant2Completed1
DB12344Fezakinumab2Active Not Recruiting1
DB12322GW-8700862Completed1
DB00602Ivermectin2Not Yet Recruiting1
DB12711LTX-1092Completed1
DB11914Lebrikizumab2Completed2
DB11914Lebrikizumab2Recruiting1
DB11856Ligelizumab2Completed1
DB12041Mapracorat2Completed5
DB06612Mepolizumab2Terminated1
DB11900OC-4592Completed1
DB09535Octocrylene2Unknown Status1
DB00043Omalizumab2Completed1
DB06610Omiganan2Completed1
DB12427Orvepitant2Withdrawn1
DB09140Oxygen2Completed1
DB12428PAC-140282Completed2
DB00337Pimecrolimus2Completed3
DB01656Roflumilast2Completed1
DB08877Ruxolitinib2Completed1
DB09029Secukinumab2Recruiting1
DB12973Serlopitant2Completed1
DB01582Sulfamethazine2Recruiting1
DB01015Sulfamethoxazole2Recruiting1
DB00864Tacrolimus2Completed6
DB06083Tapinarof2Completed2
DB12580Tradipitant2Completed1
DB12169Tralokinumab2Completed1
DB00620Triamcinolone2Completed2
DB08604Triclosan2Unknown Status1
DB00440Trimethoprim2Recruiting1
DB05679Ustekinumab2Completed2
DB12159Dupilumab2 / 3Recruiting1
DB00950Fexofenadine2 / 3Completed1
DB00581Lactulose2 / 3Completed1
DB11817Baricitinib3Recruiting5
DB12216Bergapten3Completed1
DB00443Betamethasone3Completed1
DB00443Betamethasone3Unknown Status1
DB00091Cyclosporine3Completed1
DB00967Desloratadine3Completed1
DB01260Desonide3Completed1
DB01260Desonide3Unknown Status1
DB12159Dupilumab3Active Not Recruiting1
DB12159Dupilumab3Completed5
DB12159Dupilumab3Enrolling by Invitation2
DB12159Dupilumab3Recruiting1
DB00588Fluticasone propionate3Terminated1
DB04077Glycerin3Completed1
DB06282Levocetirizine3Completed1
DB00563Methotrexate3Completed1
DB12428PAC-140283Recruiting1
DB00337Pimecrolimus3Completed7
DB00860Prednisolone3Unknown Status1
DB00864Tacrolimus3Completed4
DB12169Tralokinumab3Active Not Recruiting2
DB12169Tralokinumab3Not Yet Recruiting1
DB12169Tralokinumab3Recruiting1
DB03904Urea3Completed1
DB00092Alefacept4Completed1
DB00523Alitretinoin4Terminated1
DB00443Betamethasone4Terminated1
DB00257Clotrimazole4Terminated1
DB11082Coal tar4Recruiting1
DB05219Crisaborole4Recruiting1
DB00091Cyclosporine4Terminated1
DB01260Desonide4Completed3
DB12159Dupilumab4Not Yet Recruiting2
DB11358Evening primrose oil4Completed1
DB01047Fluocinonide4Completed1
DB01047Fluocinonide4Unknown Status1
DB00588Fluticasone propionate4Completed4
DB00798Gentamicin4Terminated1
DB00741Hydrocortisone4Completed2
DB00741Hydrocortisone4Withdrawn1
DB00125L-Arginine4Withdrawn1
DB06282Levocetirizine4Completed1
DB12583Maltodextrin4Enrolling by Invitation1
DB00959Methylprednisolone4Completed1
DB00764Mometasone4Completed1
DB00471Montelukast4Completed2
DB00471Montelukast4Not Yet Recruiting1
DB00410Mupirocin4Completed1
DB00043Omalizumab4Active Not Recruiting1
DB00043Omalizumab4Completed2
DB00337Pimecrolimus4Completed18
DB00337Pimecrolimus4Terminated2
DB00860Prednisolone4Completed1
DB01256Retapamulin4Completed1
DB01256Retapamulin4Withdrawn1
DB00864Tacrolimus4Completed8
DB00864Tacrolimus4Withdrawn1
DB00620Triamcinolone4Active Not Recruiting1
DB00620Triamcinolone4Completed1
DB09145Water4Completed1
DB00051AdalimumabNot AvailableCompleted1
DB05676ApremilastNot AvailableCompleted1
DB12768BCG vaccineNot AvailableCompleted1
DB11286Colloidal oatmealNot AvailableCompleted1
DB00091CyclosporineNot AvailableCompleted1
DB09095DifluocortoloneNot AvailableCompleted1
DB08801DimetindeneNot AvailableCompleted1
DB12159DupilumabNot AvailableEnrolling by Invitation1
DB12159DupilumabNot AvailableRecruiting2
DB00153ErgocalciferolNot AvailableCompleted1
DB00153ErgocalciferolNot AvailableTerminated1
DB00005EtanerceptNot AvailableCompleted1
DB01047FluocinonideNot AvailableCompleted1
DB00741HydrocortisoneNot AvailableCompleted1
DB00741HydrocortisoneNot AvailableRecruiting1
DB11123HypochloriteNot AvailableCompleted1
DB00065InfliximabNot AvailableCompleted1
DB00065InfliximabNot AvailableRecruiting1
DB00563MethotrexateNot AvailableActive Not Recruiting1
DB00471MontelukastNot AvailableCompleted1
DB00337PimecrolimusNot AvailableCompleted1
DB00337PimecrolimusNot AvailableRecruiting1
DB01132PioglitazoneNot AvailableWithdrawn1
DB00635PrednisoneNot AvailableNot Yet Recruiting1
DB06815Pyrithione zincNot AvailableRecruiting1
DB00073RituximabNot AvailableCompleted1
DB09029SecukinumabNot AvailableRecruiting1
DB00620TriamcinoloneNot AvailableWithdrawn1
DB11601Tuberculin Purified Protein DerivativeNot AvailableActive Not Recruiting1
DB05679UstekinumabNot AvailableCompleted1
DB05679UstekinumabNot AvailableRecruiting1
DB00126Vitamin CNot AvailableCompleted1
DB11094Vitamin DNot AvailableCompleted1
DB11094Vitamin DNot AvailableTerminated1