Tiredness

Also known as: Exhaustion / Lethargy / Fatigue / Fatigue and tiredness / Worn out / Exhaustion (finding) / Washed-out / Other fatigue / Lethargy (finding) / Lethargic / Fatigue (finding) / Loss of energy / Energy decreased / Feeling of total lack of energy / Tired out / Fatigue extreme / Weariness / Lack of energy (finding)

DrugDrug NameDrug Description
DB00118AdemetionineS-Adenosylmethionine (SAMe) is used as a drug in Europe for the treatment of depression, liver disorders, fibromyalgia, and osteoarthritis. It has also been introduced into the United States market as...
DB15993Arginine aspartateAn ingredient in products indicated to treat exhaustion during stress, endurance sports, or in the elderly.
DB00201CaffeineA stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth.
DB00536GuanidineA strong organic base used to treat muscle weakness and fatigue associated with the myasthenic complications of Eaton-Lambert syndrome.
DB00745ModafinilA stimulant used to improve wakefulness in patients with sleep apnea, narcolepsy, or shift work disorder.
DB11584PipradrolA central nervous stimulant ingredient in a product used to treat functional fatigue.
DB08811TofisopamFor the treatment of anxiety and alcohol withdrawal.
DrugDrug NameTargetType
DB00118AdemetionineGlycine N-methyltransferasetarget
DB00118AdemetionineS-adenosylmethionine decarboxylase proenzymetarget
DB00118AdemetionineS-adenosylmethionine synthase isoform type-2target
DB00118AdemetionineCystathionine beta-synthasetarget
DB00118AdemetionineS-adenosylmethionine synthase isoform type-1target
DB00118AdemetionineCytochrome P450 2E1enzyme
DB00118AdemetionineCatechol O-methyltransferasetarget
DB00118AdemetionineSpermidine synthaseenzyme
DB00118AdemetionineCap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1target
DB00118AdemetionineArsenite methyltransferasetarget
DB00201CaffeineAdenosine receptor A1target
DB00201CaffeinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB00201CaffeineAdenosine receptor A2atarget
DB00201CaffeineCytochrome P450 1A2enzyme
DB00201CaffeineRyanodine receptor 1target
DB00201CaffeineCytochrome P450 3A4enzyme
DB00201CaffeineCytochrome P450 2E1enzyme
DB00201CaffeineCytochrome P450 2C8enzyme
DB00201CaffeineCytochrome P450 2C9enzyme
DB00201CaffeineCytochrome P450 1A1enzyme
DB00201CaffeineCytochrome P450 1B1enzyme
DB00201CaffeineCytochrome P450 2D6enzyme
DB00201CaffeineCyclic nucleotide phosphodiesterasetarget
DB00201CaffeineDNA-dependent protein kinase catalytic subunittarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformtarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformtarget
DB00201CaffeineInositol 1,4,5-trisphosphate receptortarget
DB00201CaffeineSerine-protein kinase ATMtarget
DB00201CaffeineATP-binding cassette sub-family G member 2transporter
DB00201CaffeineAdenosine receptor A2btarget
DB00201CaffeineAdenosine receptor A3target
DB00201CaffeinePhosphodiesterase enzymestarget
DB00536GuanidineRibonuclease pancreatictarget
DB00536GuanidineDNAtarget
DB00536GuanidineDisks large homolog 4target
DB00536GuanidineLysozymetarget
DB00536GuanidineAldehyde dehydrogenase, mitochondrialtarget
DB00536GuanidineGuanidinoacetate N-methyltransferasetarget
DB00536GuanidineArginasetarget
DB00536GuanidineSolute carrier family 22 member 2transporter
DB00536GuanidineSolute carrier family 22 member 1transporter
DB00536GuanidineSolute carrier family 22 member 3transporter
DB00536GuanidineSolute carrier family 22 member 5transporter
DB00536GuanidineSolute carrier family 22 member 8transporter
DB00536GuanidineSolute carrier family 22 member 4transporter
DB00536GuanidineMultidrug and toxin extrusion protein 1transporter
DB00536GuanidineMultidrug and toxin extrusion protein 2transporter
DB00745ModafinilSodium-dependent dopamine transportertarget
DB00745ModafinilAlpha-1B adrenergic receptortarget
DB00745ModafinilCytochrome P450 3A4enzyme
DB00745ModafinilCytochrome P450 2C19enzyme
DB00745ModafinilCytochrome P450 1A2enzyme
DB00745ModafinilCytochrome P450 2B6enzyme
DB00745ModafinilCytochrome P450 2C9enzyme
DB00745ModafinilCytochrome P450 3A5enzyme
DB00745ModafinilCytochrome P450 2D6enzyme
DB11584PipradrolD(1) dopamine receptortarget
DB08811TofisopamcAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DB08811TofisopamcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Atarget
DB08811TofisopamcGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
DB08811TofisopamcGMP-dependent 3',5'-cyclic phosphodiesterasetarget
DB08811TofisopamCytochrome P450 3A4enzyme
DrugDrug NamePhaseStatusCount
DB00945Acetylsalicylic acid0Completed1
DB01221Ketamine0Terminated1
DB00683Midazolam0Terminated1
DB00331Metformin1Completed1
DB00422Methylphenidate1Completed1
DB00745Modafinil1Completed2
DB00503Ritonavir1Completed1
DB06413Armodafinil1 / 2Completed1
DB00822Disulfiram1 / 2Completed1
DB01221Ketamine1 / 2Completed1
DB01221Ketamine1 / 2Recruiting1
DB00683Midazolam1 / 2Completed1
DB00683Midazolam1 / 2Recruiting1
DB05063Mitoquinone1 / 2Recruiting1
DB05063Mitoquinone1 / 2Terminated1
DB11640Amifampridine2Completed1
DB00026Anakinra2Completed1
DB06413Armodafinil2Completed3
DB06413Armodafinil2Terminated1
DB00126Ascorbic acid2Withdrawn1
DB00958Carboplatin2Unknown Status1
DB00515Cisplatin2Completed1
DB00151Cysteine2Completed1
DB06637Dalfampridine2Completed2
DB06701Dexmethylphenidate2Completed1
DB00843Donepezil2Completed1
DB00016Erythropoietin2Completed2
DB00472Fluoxetine2Completed1
DB00441Gemcitabine2Completed1
DB01404Ginseng2Completed1
DB08887Icosapent ethyl2Terminated1
DB00065Infliximab2Terminated1
DB04465Lactose2Terminated1
DB00480Lenalidomide2Active Not Recruiting1
DB00480Lenalidomide2Completed1
DB12583Maltodextrin2Unknown Status1
DB00351Megestrol acetate2Completed1
DB01065Melatonin2Completed1
DB00422Methylphenidate2Completed1
DB00422Methylphenidate2Terminated2
DB00422Methylphenidate2Unknown Status1
DB00745Modafinil2Completed2
DB00745Modafinil2Terminated2
DB08935Obinutuzumab2Active Not Recruiting1
DB11988Ocrelizumab2Withdrawn1
DB06650Ofatumumab2Completed1
DB00635Prednisone2Completed1
DB02789Pregnenolone2Completed1
DB12614Reparixin2Withdrawn1
DB00073Rituximab2Completed2
DB00073Rituximab2Withdrawn1
DB08839Serotonin2Completed1
DB01390Sodium bicarbonate2Recruiting1
DB09299Tenofovir alafenamide2Withdrawn1
DB00624Testosterone2Recruiting1
DB13946Testosterone undecanoate2Terminated1
DB00361Vinorelbine2Unknown Status1
DB11195Xylitol2Completed1
DB06413Armodafinil2 / 3Completed1
DB01234Dexamethasone2 / 3Active Not Recruiting1
DB01065Melatonin2 / 3Completed2
DB01065Melatonin2 / 3Recruiting1
DB00422Methylphenidate2 / 3Completed1
DB00422Methylphenidate2 / 3Recruiting1
DB08842Acetylcarnitine3Completed1
DB00945Acetylsalicylic acid3Terminated1
DB00915Amantadine3Recruiting1
DB06413Armodafinil3Completed2
DB00126Ascorbic acid3Terminated1
DB00958Carboplatin3Unknown Status1
DB01234Dexamethasone3Completed1
DB01248Docetaxel3Completed1
DB00016Erythropoietin3Completed1
DB01175Escitalopram3Terminated1
DB00990Exemestane3Completed1
DB14491Ferrous fumarate3Terminated1
DB00644Gonadorelin3Completed1
DB00065Infliximab3Completed1
DB00281Lidocaine3Completed1
DB00422Methylphenidate3Completed3
DB00422Methylphenidate3Recruiting1
DB00422Methylphenidate3Terminated2
DB00745Modafinil3Completed1
DB00745Modafinil3Not Yet Recruiting1
DB01229Paclitaxel3Unknown Status1
DB14296Panax quinquefolius whole3Completed1
DB06614Peramivir3Completed1
DB00234Reboxetine3Recruiting1
DB00052Somatotropin3Completed1
DB00675Tamoxifen3Completed1
DB06825Triptorelin3Completed1
DB00163Vitamin E3Terminated1
DB08842Acetylcarnitine4Completed1
DB00915Amantadine4Completed1
DB00182Amphetamine4Not Yet Recruiting1
DB06413Armodafinil4Completed1
DB01156Bupropion4Completed1
DB00924Cyclobenzaprine4Terminated1
DB01189Desflurane4Completed1
DB06262Droxidopa4Terminated1
DB00016Erythropoietin4Completed1
DB08917Ferric carboxymaltose4Completed1
DB08917Ferric carboxymaltose4Unknown Status1
DB13257Ferrous sulfate anhydrous4Completed1
DB01404Ginseng4Completed1
DB14152Ginsenosides4Completed1
DB13178Inositol4Completed1
DB15763Iron polymaltose4Completed1
DB00451Levothyroxine4Completed1
DB00959Methylprednisolone4Completed2
DB00683Midazolam4Completed1
DB00745Modafinil4Completed2
DB00745Modafinil4Unknown Status1
DB00635Prednisone4Completed1
DB00818Propofol4Completed1
DB00140Riboflavin4Completed1
DB00740Riluzole4Completed1
DB09153Sodium chloride4Completed1
DB09153Sodium chloride4Unknown Status1
DB09034Suvorexant4Completed1
DB01956Taurine4Completed1
DB00152Thiamine4Completed3
DB01586Ursodeoxycholic acid4Completed2
DB00051AdalimumabNot AvailableActive Not Recruiting1
DB00051AdalimumabNot AvailableCompleted1
DB01060AmoxicillinNot AvailableCompleted1
DB06413ArmodafinilNot AvailableWithdrawn1
DB11817BaricitinibNot AvailableActive Not Recruiting1
DB00958CarboplatinNot AvailableCompleted1
DB08904Certolizumab pegolNot AvailableActive Not Recruiting1
DB00531CyclophosphamideNot AvailableCompleted1
DB01234DexamethasoneNot AvailableCompleted1
DB00514DextromethorphanNot AvailableTerminated1
DB01248DocetaxelNot AvailableCompleted1
DB00997DoxorubicinNot AvailableCompleted1
DB00254DoxycyclineNot AvailableCompleted1
DB00016ErythropoietinNot AvailableTerminated1
DB00016ErythropoietinNot AvailableWithdrawn1
DB00402EszopicloneNot AvailableCompleted1
DB00005EtanerceptNot AvailableActive Not Recruiting1
DB06674GolimumabNot AvailableActive Not Recruiting1
DB00065InfliximabNot AvailableActive Not Recruiting1
DB00583LevocarnitineNot AvailableWithdrawn1
DB00451LevothyroxineNot AvailableCompleted1
DB00331MetforminNot AvailableUnknown Status1
DB00422MethylphenidateNot AvailableUnknown Status1
DB14158Microcrystalline celluloseNot AvailableCompleted1
DB00745ModafinilNot AvailableCompleted1
DB00745ModafinilNot AvailableUnknown Status1
DB12612OzanimodNot AvailableNot Yet Recruiting1
DB00203SildenafilNot AvailableCompleted2
DB01268SunitinibNot AvailableTerminated1
DB00820TadalafilNot AvailableCompleted1
DB00759TetracyclineNot AvailableCompleted1
DB08895TofacitinibNot AvailableActive Not Recruiting1
DB00072TrastuzumabNot AvailableCompleted1