Tiredness

Also known as: Lethargy / Fatigue / Fatigue NOS / Lethargic / Loss of energy / Energy decreased / Feeling of total lack of energy / Tired out / Fatigue extreme / Weariness

DrugDrug NameDrug Description
DB00915AmantadineA medication used to treat dyskinesia in Parkinson's patients receiving levodopa, as well as extrapyramidal side effects of medications.
DB00201CaffeineA stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth.
DB00745ModafinilA stimulant used to improve wakefulness in patients with sleep apnea, narcolepsy, or shift work disorder.
DB11584PipradrolA central nervous stimulant ingredient in a product used to treat functional fatigue.
DrugDrug NameTargetType
DB00915AmantadineDopamine D2 receptortarget
DB00915AmantadineMatrix protein 2target
DB00915AmantadineAromatic-L-amino-acid decarboxylaseenzyme
DB00915AmantadineAmine oxidase [flavin-containing] Benzyme
DB00915AmantadineSolute carrier family 22 member 2transporter
DB00915AmantadineSolute carrier family 22 member 1transporter
DB00915AmantadineGlutamate receptor ionotropic, NMDA 3Atarget
DB00915AmantadineNeuronal acetylcholine receptor subunit alpha-7target
DB00915AmantadineNeuronal acetylcholine receptor subunit alpha-4target
DB00915AmantadineNeuronal acetylcholine receptor subunit alpha-3target
DB00201CaffeineAdenosine receptor A1target
DB00201CaffeinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB00201CaffeineAdenosine receptor A2atarget
DB00201CaffeineCytochrome P450 1A2enzyme
DB00201CaffeineRyanodine receptor 1target
DB00201CaffeineCytochrome P450 3A4enzyme
DB00201CaffeineCytochrome P450 2E1enzyme
DB00201CaffeineCytochrome P450 2C8enzyme
DB00201CaffeineCytochrome P450 2C9enzyme
DB00201CaffeineCytochrome P450 1A1enzyme
DB00201CaffeineCytochrome P450 1B1enzyme
DB00201CaffeineCytochrome P450 2D6enzyme
DB00201CaffeineCyclic nucleotide phosphodiesterasetarget
DB00201CaffeineDNA-dependent protein kinase catalytic subunittarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformtarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformtarget
DB00201CaffeineInositol 1,4,5-trisphosphate receptortarget
DB00201CaffeineSerine-protein kinase ATMtarget
DB00201CaffeineATP-binding cassette sub-family G member 2transporter
DB00201CaffeineAdenosine receptor A2btarget
DB00201CaffeineAdenosine receptor A3target
DB00201CaffeinePhosphodiesterase enzymestarget
DB00745ModafinilSodium-dependent dopamine transportertarget
DB00745ModafinilAlpha-1B adrenergic receptortarget
DB00745ModafinilCytochrome P450 3A4enzyme
DB00745ModafinilCytochrome P450 2C19enzyme
DB00745ModafinilCytochrome P450 1A2enzyme
DB00745ModafinilCytochrome P450 2B6enzyme
DB00745ModafinilCytochrome P450 2C9enzyme
DB00745ModafinilCytochrome P450 3A5enzyme
DB11584PipradrolD(1) dopamine receptortarget
DrugDrug NamePhaseStatusCount
DB00945Acetylsalicylic acid0Completed1
DB01221Ketamine0Terminated1
DB00683Midazolam0Terminated1
DB00331Metformin1Active Not Recruiting1
DB00422Methylphenidate1Active Not Recruiting1
DB00745Modafinil1Completed2
DB00503Ritonavir1Active Not Recruiting1
DB06413Armodafinil1 / 2Active Not Recruiting1
DB00188Bortezomib1 / 2Active Not Recruiting1
DB01234Dexamethasone1 / 2Active Not Recruiting1
DB00822Disulfiram1 / 2Recruiting1
DB12121Entospletinib1 / 2Recruiting1
DB01221Ketamine1 / 2Completed1
DB01221Ketamine1 / 2Not Yet Recruiting1
DB00683Midazolam1 / 2Completed1
DB00683Midazolam1 / 2Not Yet Recruiting1
DB05063Mitoquinone1 / 2Recruiting1
DB08935Obinutuzumab1 / 2Recruiting1
DB00073Rituximab1 / 2Active Not Recruiting1
DB00877Sirolimus1 / 2Active Not Recruiting1
DB06287Temsirolimus1 / 2Active Not Recruiting1
DB11640Amifampridine2Completed1
DB00026Anakinra2Completed1
DB06413Armodafinil2Completed3
DB06413Armodafinil2Terminated1
DB00126Ascorbic acid2Not Yet Recruiting1
DB00958Carboplatin2Unknown Status1
DB00515Cisplatin2Completed1
DB06637Dalfampridine2Completed2
DB01234Dexamethasone2Active Not Recruiting1
DB06701Dexmethylphenidate2Completed1
DB00843Donepezil2Completed1
DB00016Erythropoietin2Completed2
DB00472Fluoxetine2Completed1
DB00441Gemcitabine2Completed1
DB01404Ginseng2Completed1
DB08887Icosapent ethyl2Active Not Recruiting1
DB00065Infliximab2Terminated1
DB00151L-Cysteine2Completed1
DB04465Lactose2Terminated1
DB00480Lenalidomide2Active Not Recruiting1
DB00480Lenalidomide2Completed1
DB12583Maltodextrin2Recruiting1
DB00351Megestrol acetate2Completed1
DB01065Melatonin2Completed1
DB00422Methylphenidate2Completed1
DB00422Methylphenidate2Recruiting1
DB00422Methylphenidate2Terminated2
DB00745Modafinil2Completed2
DB00745Modafinil2Terminated2
DB08935Obinutuzumab2Active Not Recruiting1
DB06650Ofatumumab2Completed1
DB02789Pregnenolone2Completed1
DB00073Rituximab2Completed2
DB08839Serotonin2Recruiting1
DB13946Testosterone undecanoate2Terminated1
DB00361Vinorelbine2Unknown Status1
DB11195Xylitol2Completed1
DB06413Armodafinil2 / 3Completed1
DB01065Melatonin2 / 3Completed2
DB00422Methylphenidate2 / 3Recruiting1
DB08842Acetylcarnitine3Completed1
DB00945Acetylsalicylic acid3Terminated1
DB06413Armodafinil3Active Not Recruiting1
DB06413Armodafinil3Completed1
DB00126Ascorbic acid3Terminated1
DB00958Carboplatin3Active Not Recruiting1
DB00531Cyclophosphamide3Active Not Recruiting1
DB01234Dexamethasone3Completed1
DB01248Docetaxel3Completed1
DB00843Donepezil3Completed1
DB00016Erythropoietin3Completed1
DB01175Escitalopram3Terminated1
DB00990Exemestane3Completed1
DB14491Ferrous fumarate3Terminated1
DB01073Fludarabine3Active Not Recruiting1
DB00644Gonadorelin3Completed1
DB09053Ibrutinib3Active Not Recruiting1
DB00065Infliximab3Completed1
DB00281Lidocaine3Completed1
DB00422Methylphenidate3Completed2
DB00422Methylphenidate3Terminated2
DB00745Modafinil3Completed1
DB01229Paclitaxel3Active Not Recruiting1
DB14296Panax quinquefolius whole3Completed1
DB06614Peramivir3Completed1
DB00635Prednisone3Recruiting1
DB00073Rituximab3Active Not Recruiting1
DB00052Somatotropin3Recruiting1
DB00675Tamoxifen3Completed1
DB06825Triptorelin3Completed1
DB00163Vitamin E3Terminated1
DB08842Acetylcarnitine4Completed1
DB00915Amantadine4Completed1
DB06413Armodafinil4Completed1
DB01156Bupropion4Completed1
DB00924Cyclobenzaprine4Unknown Status1
DB01189Desflurane4Completed1
DB06262Droxidopa4Recruiting1
DB00016Erythropoietin4Completed1
DB08917Ferric carboxymaltose4Completed1
DB08917Ferric carboxymaltose4Not Yet Recruiting1
DB13257Ferrous sulfate anhydrous4Completed1
DB01404Ginseng4Completed1
DB14152Ginsenosides4Completed1
DB13178Inositol4Completed1
DB01592Iron4Completed1
DB00451Levothyroxine4Completed1
DB00959Methylprednisolone4Completed2
DB00683Midazolam4Completed1
DB00745Modafinil4Completed2
DB00745Modafinil4Recruiting1
DB00635Prednisone4Active Not Recruiting1
DB00818Propofol4Completed1
DB00140Riboflavin4Completed1
DB00740Riluzole4Recruiting1
DB09153Sodium chloride4Completed1
DB09153Sodium chloride4Not Yet Recruiting1
DB09034Suvorexant4Recruiting1
DB01956Taurine4Completed1
DB00152Thiamine4Active Not Recruiting1
DB00152Thiamine4Completed2
DB01586Ursodeoxycholic acid4Completed2
DB00051AdalimumabNot AvailableRecruiting1
DB01060AmoxicillinNot AvailableRecruiting1
DB06413ArmodafinilNot AvailableWithdrawn1
DB00958CarboplatinNot AvailableCompleted1
DB00531CyclophosphamideNot AvailableCompleted1
DB01234DexamethasoneNot AvailableCompleted1
DB00514DextromethorphanNot AvailableTerminated1
DB01248DocetaxelNot AvailableCompleted1
DB00997DoxorubicinNot AvailableCompleted1
DB00254DoxycyclineNot AvailableCompleted1
DB00016ErythropoietinNot AvailableTerminated1
DB00016ErythropoietinNot AvailableWithdrawn1
DB00402EszopicloneNot AvailableCompleted1
DB00583LevocarnitineNot AvailableWithdrawn1
DB00451LevothyroxineNot AvailableCompleted1
DB00331MetforminNot AvailableActive Not Recruiting1
DB00422MethylphenidateNot AvailableRecruiting1
DB00422MethylphenidateNot AvailableUnknown Status1
DB00745ModafinilNot AvailableCompleted1
DB00745ModafinilNot AvailableUnknown Status1
DB00203SildenafilNot AvailableCompleted2
DB01268SunitinibNot AvailableTerminated1
DB00820TadalafilNot AvailableCompleted1
DB00759TetracyclineNot AvailableCompleted1
DB00072TrastuzumabNot AvailableCompleted1