Tiredness

Also known as: Fatigue / Lethargy / Fatigue NOS / Lethargic / Loss of energy / Energy decreased / Feeling of total lack of energy / Tired out / Fatigue extreme / Weariness

DrugDrug NameDrug Description
DB00915AmantadineAn antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake. [PubChem]
DB00201CaffeineA methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes smooth muscle, stimulates cardiac muscle, stimulates diuresis, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide phosphodiesterases, antagonism of adenosine receptors, and modulation of intracellular calcium handling.
DB00745ModafinilModafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron activation is associated with psychoactivation and euphoria. The exact mechanism of action is unclear, although in vitro studies have shown it to inhibit the reuptake of dopamine by binding to the dopamine reuptake pump, and lead to an increase in extracellular dopamine. Modafinil activates glutamatergic circuits while inhibiting GABA.
DrugDrug NameTargetType
DB00915AmantadineD(2) dopamine receptortarget
DB00915AmantadineMatrix protein 2target
DB00915AmantadineAromatic-L-amino-acid decarboxylaseenzyme
DB00915AmantadineAmine oxidase [flavin-containing] Benzyme
DB00915AmantadineSolute carrier family 22 member 2transporter
DB00915AmantadineSolute carrier family 22 member 1transporter
DB00915AmantadineMultidrug resistance protein 1transporter
DB00915AmantadineGlutamate receptor ionotropic, NMDA 3Atarget
DB00201CaffeineAdenosine receptor A1target
DB00201CaffeinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB00201CaffeineAdenosine receptor A2atarget
DB00201CaffeineCytochrome P450 1A2enzyme
DB00201CaffeineRyanodine receptor 1target
DB00201CaffeineCytochrome P450 3A4enzyme
DB00201CaffeineCytochrome P450 3A5enzyme
DB00201CaffeineCytochrome P450 3A7enzyme
DB00201CaffeineMultidrug resistance protein 1transporter
DB00201CaffeineCytochrome P450 2E1enzyme
DB00201CaffeineCytochrome P450 2C8enzyme
DB00201CaffeineCytochrome P450 2C9enzyme
DB00201CaffeineCytochrome P450 1A1enzyme
DB00201CaffeineCytochrome P450 1B1enzyme
DB00201CaffeineCytochrome P450 2D6enzyme
DB00201CaffeineCyclic nucleotide phosphodiesterasetarget
DB00201CaffeineDNA-dependent protein kinase catalytic subunittarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformtarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformtarget
DB00201CaffeineInositol 1,4,5-trisphosphate receptortarget
DB00201CaffeineSerine-protein kinase ATMtarget
DB00745ModafinilSodium-dependent dopamine transportertarget
DB00745ModafinilAlpha-1B adrenergic receptortarget
DB00745ModafinilCytochrome P450 3A4enzyme
DB00745ModafinilCytochrome P450 2C19enzyme
DB00745ModafinilCytochrome P450 1A2enzyme
DB00745ModafinilCytochrome P450 2B6enzyme
DB00745ModafinilCytochrome P450 2C9enzyme
DB00745ModafinilCytochrome P450 3A5enzyme
DrugDrug NamePhaseStatusCount
DB00945Acetylsalicylic acid0Completed1
DB01221Ketamine0Recruiting1
DB00683Midazolam0Recruiting1
DB00331Metformin1Recruiting1
DB00422Methylphenidate1Recruiting1
DB00745Modafinil1Completed2
DB00503Ritonavir1Recruiting1
DB06413Armodafinil1 / 2Active Not Recruiting1
DB00188Bortezomib1 / 2Active Not Recruiting1
DB01234Dexamethasone1 / 2Active Not Recruiting1
DB12121Entospletinib1 / 2Recruiting1
DB05063Mitoquinone1 / 2Recruiting1
DB08935Obinutuzumab1 / 2Recruiting1
DB00073Rituximab1 / 2Active Not Recruiting1
DB06287Temsirolimus1 / 2Active Not Recruiting1
DB06151Acetylcysteine2Recruiting1
DB00640Adenosine2Completed1
DB00026Anakinra2Completed1
DB06413Armodafinil2Completed2
DB06413Armodafinil2Terminated1
DB00958Carboplatin2Unknown Status1
DB00515Cisplatin2Completed1
DB06637Dalfampridine2Completed1
DB06637Dalfampridine2Recruiting1
DB06701Dexmethylphenidate2Completed1
DB00843Donepezil2Completed1
DB00016Erythropoietin2Completed2
DB00472Fluoxetine2Completed1
DB00441Gemcitabine2Completed1
DB01404Ginseng2Completed1
DB00065Infliximab2Terminated1
DB00174L-Asparagine2Completed1
DB00128L-Aspartic Acid2Completed1
DB04465Lactose2Terminated1
DB12583Maltodextrin2Recruiting1
DB00351Megestrol acetate2Completed1
DB01065Melatonin2Completed1
DB00422Methylphenidate2Completed1
DB00422Methylphenidate2Recruiting1
DB00422Methylphenidate2Terminated2
DB00745Modafinil2Completed2
DB00745Modafinil2Terminated2
DB02701Nicotinamide2Completed1
DB02789Pregnenolone2Recruiting1
DB00073Rituximab2Completed2
DB00624Testosterone2Terminated1
DB00361Vinorelbine2Unknown Status1
DB00126Vitamin C2Not Yet Recruiting1
DB11195Xylitol2Active Not Recruiting1
DB06413Armodafinil2 / 3Active Not Recruiting1
DB06413Armodafinil2 / 3Completed1
DB01065Melatonin2 / 3Completed2
DB08842Acetylcarnitine3Completed1
DB00945Acetylsalicylic acid3Terminated1
DB06413Armodafinil3Completed1
DB06413Armodafinil3Recruiting1
DB00958Carboplatin3Active Not Recruiting1
DB00493Cefotaxime3Active Not Recruiting1
DB00531Cyclophosphamide3Active Not Recruiting1
DB01234Dexamethasone3Completed1
DB01248Docetaxel3Completed1
DB00843Donepezil3Completed1
DB00016Erythropoietin3Completed1
DB01175Escitalopram3Terminated1
DB00990Exemestane3Completed1
DB01073Fludarabine3Active Not Recruiting1
DB09053Ibrutinib3Active Not Recruiting1
DB00065Infliximab3Completed1
DB00281Lidocaine3Completed1
DB00422Methylphenidate3Completed2
DB00422Methylphenidate3Terminated2
DB00745Modafinil3Completed1
DB01229Paclitaxel3Active Not Recruiting1
DB06614Peramivir3Completed1
DB00635Prednisone3Recruiting1
DB00073Rituximab3Active Not Recruiting1
DB00675Tamoxifen3Completed1
DB06825Triptorelin3Completed1
DB08842Acetylcarnitine4Completed1
DB00915Amantadine4Completed1
DB06413Armodafinil4Completed1
DB01156Bupropion4Completed1
DB00924Cyclobenzaprine4Unknown Status1
DB01189Desflurane4Completed1
DB06262Droxidopa4Recruiting1
DB00016Erythropoietin4Completed1
DB08917Ferric Carboxymaltose4Completed1
DB08917Ferric Carboxymaltose4Not Yet Recruiting1
DB01592Iron4Completed1
DB00451Levothyroxine4Active Not Recruiting1
DB00959Methylprednisolone4Completed2
DB00683Midazolam4Completed1
DB00745Modafinil4Completed2
DB00745Modafinil4Recruiting1
DB00635Prednisone4Recruiting1
DB00818Propofol4Completed1
DB00740Riluzole4Recruiting1
DB09153Sodium Chloride4Completed1
DB09153Sodium Chloride4Not Yet Recruiting1
DB00051AdalimumabNot AvailableRecruiting1
DB06413ArmodafinilNot AvailableWithdrawn1
DB00958CarboplatinNot AvailableCompleted1
DB00531CyclophosphamideNot AvailableCompleted1
DB01234DexamethasoneNot AvailableCompleted1
DB00514DextromethorphanNot AvailableTerminated1
DB01248DocetaxelNot AvailableCompleted1
DB00997DoxorubicinNot AvailableCompleted1
DB00254DoxycyclineNot AvailableCompleted1
DB00016ErythropoietinNot AvailableWithdrawn1
DB00402EszopicloneNot AvailableCompleted1
DB00583L-CarnitineNot AvailableWithdrawn1
DB00451LevothyroxineNot AvailableRecruiting1
DB00331MetforminNot AvailableActive Not Recruiting1
DB00422MethylphenidateNot AvailableRecruiting1
DB00422MethylphenidateNot AvailableUnknown Status1
DB00745ModafinilNot AvailableCompleted1
DB00745ModafinilNot AvailableUnknown Status1
DB00203SildenafilNot AvailableCompleted2
DB01268SunitinibNot AvailableTerminated1
DB00820TadalafilNot AvailableCompleted1
DB00759TetracyclineNot AvailableCompleted1
DB00072TrastuzumabNot AvailableCompleted1