Pneumocystis Jirovecii Pneumonia

Also known as: Pneumonia, Pneumocystis Jerovici / Pneumonia caused by pneumocystis carinii / Pneumocystis Pneumonia / Pneumonia, Pneumocystis / Pneumocystis jiroveci / Pneumocystis Jirovecii / Pneumocysis jirovecii pneumonia / Pneumocystis jirovecii infection / Pneumocystis carinii / Pneumocystis Carinii Pneumonia / Pneumocystis Jiroveci Pneumonia / Pneumonia, Pneumocystis Carinii / Pneumocystis carinii infection / Pneumocystis Carinii Infections / Pneumocystis infections / Pneumocystis Infection / Pnuemonia caused by pneumocystis carinii / Pulmonary pneumocystosis (disorder) / Pneumocystosis / Pneumocystosis (disorder) / PCP / Pneumonia due to Pneumocystis carinii / Pneumocystosis jirovecii pneumonia (disorder) / Interstitial plasma cell pneumonia / Pneumocystis jiroveci infection / Infection by Pneumocystis jiroveci (disorder) / Infection by Pneumocystis carinii (disorder)

DrugDrug NameDrug Description
DB01117AtovaquoneAn antimicrobial indicated for the prevention and treatment of Pneumocystis jirovecii pneumonia (PCP) and for the prevention and treatment of Plasmodium falciparum malaria.
DB01190ClindamycinA lincosamide antibiotic used to treat serious infections caused by susceptible anaerobic, streptococcal, staphylococcal, and pneumococcal bacteria.
DB00693FluoresceinA dye used in angiography or angioscopy of the iris and retina.
DB00738PentamidineAn antifungal agent used to treat Pneumocystis pneumonia in patients infected with HIV.
DB00860PrednisoloneA glucocorticoid used to treat adrenocortical insufficiency, inflammatory conditions, and some cancers.
DB00635PrednisoneA corticosteroid used to treat inflammation or immune-mediated reactions and to treat endocrine or neoplastic diseases.
DB01087PrimaquineAn antimalarial indicated to prevent relapse of vivax malaria.
DB01015SulfamethoxazoleAn oral sulfonamide antibiotic, given in combination with trimethoprim, used to treat a variety of infections of the urinary tract, respiratory system, and gastrointestinal tract.
DB00440TrimethoprimAn antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract.
DB01157TrimetrexateA folate antagonist used for the treatment of moderate-to-severe Pneumocystis carinii pneumonia (PCP) in immunocompromised patients as an alternative therapy in combination with leucovorin.
DrugDrug NameTargetType
DB01117AtovaquoneDihydroorotate dehydrogenase (quinone), mitochondrialtarget
DB01117AtovaquoneDihydroorotate dehydrogenase (quinone), mitochondrialtarget
DB01117AtovaquoneCytochrome btarget
DB01117AtovaquoneCytochrome P450 2C9enzyme
DB01117AtovaquoneCytochrome P450 3A4enzyme
DB01117AtovaquoneP-glycoprotein 1transporter
DB01190ClindamycinCytochrome P450 3A4enzyme
DB01190ClindamycinCytochrome P450 3A5enzyme
DB01190ClindamycinAlpha-1-acid glycoprotein 1carrier
DB01190ClindamycinP-glycoprotein 1transporter
DB01190Clindamycin50S ribosomal protein L1target
DB00693FluoresceinIg kappa chain V-II region RPMI 6410target
DB00693FluoresceinDNAtarget
DB00693FluoresceinSolute carrier family 22 member 6transporter
DB00693FluoresceinBile salt export pumptransporter
DB00693FluoresceinMultidrug resistance-associated protein 1transporter
DB00738PentamidineDNAtarget
DB00738PentamidineCytochrome P450 2C19enzyme
DB00738PentamidinetRNA (cytosine(38)-C(5))-methyltransferasetarget
DB00738PentamidineCytochrome P450 2D6enzyme
DB00738PentamidineCytochrome P450 1A1enzyme
DB00738PentamidineCytochrome P450 3A5enzyme
DB00738PentamidineCytochrome P450 4A11enzyme
DB00860PrednisoloneCorticosteroid-binding globulincarrier
DB00860PrednisoloneCytochrome P450 3A4enzyme
DB00860PrednisoloneGlucocorticoid receptortarget
DB00860PrednisoloneSolute carrier organic anion transporter family member 1A2transporter
DB00860PrednisoloneP-glycoprotein 1transporter
DB00860PrednisoloneSerum albumincarrier
DB00635PrednisoneGlucocorticoid receptortarget
DB00635PrednisoneCytochrome P450 3A4enzyme
DB00635PrednisoneP-glycoprotein 1transporter
DB00635PrednisoneSolute carrier organic anion transporter family member 1A2transporter
DB00635PrednisoneCytochrome P450 2C19enzyme
DB00635PrednisoneSerum albumincarrier
DB00635PrednisoneCytochrome P450 3A5enzyme
DB00635PrednisoneCorticosteroid-binding globulincarrier
DB00635PrednisoneCytochrome P450 3A Subfamilyenzyme
DB00635PrednisoneCytochrome P450 2A6enzyme
DB00635PrednisoneCytochrome P450 1B1enzyme
DB00635PrednisoneCytochrome P450 2B6enzyme
DB00635PrednisoneCytochrome P450 2C8enzyme
DB00635PrednisoneCytochrome P450 2C9enzyme
DB00635PrednisoneCorticosteroid 11-beta-dehydrogenase isozyme 1enzyme
DB01087PrimaquineCytochrome P450 1A1enzyme
DB01087PrimaquineCytochrome P450 1A2enzyme
DB01087PrimaquineCytochrome P450 3A4enzyme
DB01087PrimaquineKeratin, type II cytoskeletal 7target
DB01087PrimaquineCytochrome P450 1B1enzyme
DB01087PrimaquineCytochrome P450 2D6enzyme
DB01087PrimaquineRibosyldihydronicotinamide dehydrogenase [quinone]target
DB01087PrimaquineFe(II)-protoporphyrin IXtarget
DB01087PrimaquineP-glycoprotein 1transporter
DB01015SulfamethoxazoleCytochrome P450 2C9enzyme
DB01015SulfamethoxazoleSerum albumincarrier
DB01015SulfamethoxazoleArylamine N-acetyltransferase 1enzyme
DB01015SulfamethoxazoleArylamine N-acetyltransferase 2enzyme
DB01015SulfamethoxazoleDihydropteroate synthasetarget
DB01015SulfamethoxazoleCytochrome P450 3A4enzyme
DB01015SulfamethoxazoleBile salt export pumptransporter
DB00440TrimethoprimDihydrofolate reductasetarget
DB00440TrimethoprimCytochrome P450 2C8enzyme
DB00440TrimethoprimCytochrome P450 3A4enzyme
DB00440TrimethoprimP-glycoprotein 1transporter
DB00440TrimethoprimCytochrome P450 2C9enzyme
DB00440TrimethoprimCytochrome P450 1A2enzyme
DB00440TrimethoprimMultidrug and toxin extrusion protein 1transporter
DB00440TrimethoprimMultidrug and toxin extrusion protein 2transporter
DB01157TrimetrexateDihydrofolate reductasetarget
DB01157TrimetrexateDihydrofolate reductaseenzyme
DB01157TrimetrexateFolate transporter 1transporter
DrugDrug NamePhaseStatusCount
DB01117Atovaquone1Completed1
DB00250Dapsone1Completed2
DB00650Leucovorin1Completed2
DB00738Pentamidine1Completed2
DB04909Sitamaquine1Completed1
DB01015Sulfamethoxazole1Completed1
DB00440Trimethoprim1Completed1
DB01157Trimetrexate1Completed2
DB01117Atovaquone2Completed3
DB00207Azithromycin2Completed1
DB00738Pentamidine2Completed1
DB04909Sitamaquine2Completed1
DB01015Sulfamethoxazole2Completed2
DB00440Trimethoprim2Completed2
DB00951Isoniazid2 / 3Terminated1
DB01015Sulfamethoxazole2 / 3Terminated1
DB01015Sulfamethoxazole2 / 3Unknown Status1
DB00440Trimethoprim2 / 3Terminated1
DB00440Trimethoprim2 / 3Unknown Status1
DB01117Atovaquone3Completed2
DB01190Clindamycin3Completed1
DB09065Cobicistat3Recruiting1
DB00250Dapsone3Completed4
DB01264Darunavir3Recruiting1
DB01611Hydroxychloroquine3Completed1
DB00650Leucovorin3Completed5
DB00650Leucovorin3Terminated1
DB00959Methylprednisolone3Terminated1
DB00959Methylprednisolone3Withdrawn1
DB06532Pafuramidine3Terminated1
DB00738Pentamidine3Completed6
DB00738Pentamidine3Terminated1
DB01087Primaquine3Completed1
DB00205Pyrimethamine3Completed1
DB01299Sulfadoxine3Completed1
DB01015Sulfamethoxazole3Completed7
DB01015Sulfamethoxazole3Terminated2
DB00440Trimethoprim3Completed7
DB00440Trimethoprim3Terminated2
DB01157Trimetrexate3Completed5
DB01157Trimetrexate3Terminated1
DB00495Zidovudine3Completed2
DB01117Atovaquone4Withdrawn1
DB00520Caspofungin4Recruiting1
DB01190Clindamycin4Withdrawn1
DB00250Dapsone4Recruiting1
DB00250Dapsone4Withdrawn1
DB00959Methylprednisolone4Recruiting1
DB00738Pentamidine4Withdrawn1
DB00635Prednisone4Withdrawn1
DB01087Primaquine4Withdrawn1
DB01015Sulfamethoxazole4Completed2
DB01015Sulfamethoxazole4Withdrawn1
DB00263Sulfisoxazole4Recruiting1
DB00440Trimethoprim4Completed2
DB00440Trimethoprim4Recruiting1
DB00440Trimethoprim4Withdrawn1
DB01117AtovaquoneNot AvailableCompleted2
DB00520CaspofunginNot AvailableRecruiting1
DB01190ClindamycinNot AvailableCompleted1
DB00250DapsoneNot AvailableCompleted2
DB00650LeucovorinNot AvailableCompleted5
DB00959MethylprednisoloneNot AvailableRecruiting1
DB00738PentamidineNot AvailableCompleted10
DB00635PrednisoneNot AvailableCompleted1
DB01087PrimaquineNot AvailableCompleted1
DB01015SulfamethoxazoleNot AvailableCompleted2
DB00440TrimethoprimNot AvailableCompleted2
DB01157TrimetrexateNot AvailableCompleted4
DB00495ZidovudineNot AvailableCompleted1