Menopausal Hot Flushes

Also known as: Hot flushes / Hot flashes / Hot flush / Hot Flash / Flashes, Hot / Climacteric flushing / Menopause flushing / Hot flushes menopausal / Feeling of hot flushes / Hot flushes, menopausal / Flush hot / Flash hot / Hot flushes NOS

DrugDrug NameDrug Description
DB00575ClonidineClonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors.[A180559] This activity is useful for the treatment of hypertension, severe pain, and ADHD.[L7237,L7240,L7243,L7246] Clonidine was granted FDA approval on 3 September 1974.[L7237]
DB06700DesvenlafaxineDesvenlafaxine (O-desmethylvenlafaxine) the major active metabolite of venlafaxine, is an antidepressant from the serotonin norepinephrine reuptake inhibitor (SNRI) class[Label]. Desvenlafaxine may be used to treat major depressive disorder[Label]. It is formulated as an extended release tablet[Label]. Desvenlafaxine was approved by the FDA in 2008[L6016].
DB01175EscitalopramEscitalopram, the S-enantiomer of citalopram, belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. SSRIs are potent inhibitors of neuronal serotonin reuptake. They have little to no effect on norepinephrine or dopamine reuptake and do not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors. During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Chronic use leads to desensitization of somatodendritic 5-HT1A and terminal autoreceptors. The overall clinical effect of increased mood and decreased anxiety is thought to be due to adaptive changes in neuronal function that leads to enhanced serotonergic neurotransmission. Side effects include dry mouth, nausea, dizziness, drowsiness, sexual dysfunction and headache. Side effects generally occur within the first two weeks of therapy and are usually less severe and frequent than those observed with tricyclic antidepressants. Escitalopram may be used to treat major depressive disorder (MDD) and generalized anxiety disorder (GAD).
DB00996GabapentinGabapentin (brand name Neurontin) is a medication originally developed for the treatment of epilepsy. Presently, gabapentin is widely used to relieve pain, especially neuropathic pain. Gabapentin is well tolerated in most patients, has a relatively mild side-effect profile, and passes through the body unmetabolized.
DB00370MirtazapineMirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994.[A177946] This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6157] The effects of this drug may be observed as early as 1 week after beginning therapy.[A178144,L6160] In addition to its beneficial effects in depression, mirtazapine has been reported to be efficacious in the off-label management of various other conditions. It may improve the symptoms of neurological disorders, reverse weight loss caused by medical conditions, improve sleep, and prevent nausea and vomiting after surgery.[A177811]
DB01323St. John's WortNot Available
DrugDrug NameTargetType
DB00575ClonidineAlpha-2A adrenergic receptortarget
DB00575ClonidineCytochrome P450 2D6enzyme
DB00575ClonidineAlpha-2B adrenergic receptortarget
DB00575ClonidineAlpha-2C adrenergic receptortarget
DB00575ClonidineSolute carrier family 22 member 3transporter
DB00575ClonidineSolute carrier family 22 member 5transporter
DB00575ClonidineSolute carrier family 22 member 4transporter
DB00575ClonidineMultidrug resistance protein 1transporter
DB00575ClonidineCytochrome P450 1A2enzyme
DB00575ClonidineCytochrome P450 3A4enzyme
DB00575ClonidineCytochrome P450 1A1enzyme
DB00575ClonidineCytochrome P450 3A5enzyme
DB00575ClonidineAlpha-1A adrenergic receptortarget
DB00575ClonidineAlpha-1B adrenergic receptortarget
DB00575ClonidineAlpha-1D adrenergic receptortarget
DB00575ClonidineSerum albumincarrier
DB06700DesvenlafaxineCytochrome P450 3A4enzyme
DB06700DesvenlafaxineSodium-dependent serotonin transportertarget
DB06700DesvenlafaxineSodium-dependent noradrenaline transportertarget
DB06700DesvenlafaxineCytochrome P450 2D6enzyme
DB06700DesvenlafaxineSodium-dependent dopamine transportertarget
DB01175EscitalopramSodium-dependent serotonin transportertarget
DB01175EscitalopramCytochrome P450 3A4enzyme
DB01175EscitalopramCytochrome P450 2D6enzyme
DB01175EscitalopramSodium-dependent dopamine transportertarget
DB01175EscitalopramSodium-dependent noradrenaline transportertarget
DB01175EscitalopramAlpha-1A adrenergic receptortarget
DB01175EscitalopramMuscarinic acetylcholine receptor M1target
DB01175EscitalopramHistamine H1 receptortarget
DB01175EscitalopramCytochrome P450 2C19enzyme
DB00996GabapentinAdenosine receptor A1target
DB00996GabapentinVoltage-dependent N-type calcium channel subunit alpha-1Btarget
DB00996GabapentinVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB00996GabapentinVoltage-dependent calcium channel subunit alpha-2/delta-2target
DB00996GabapentinBranched-chain-amino-acid aminotransferase, cytosolicenzyme
DB00996GabapentinNMDA receptortarget
DB00996GabapentinGamma-aminobutyric acid type B receptor subunit 1target
DB00996GabapentinGamma-aminobutyric acid type B receptor subunit 2target
DB00996GabapentinCytochrome P450 3A4enzyme
DB00370Mirtazapine5-hydroxytryptamine receptor 2Atarget
DB00370Mirtazapine5HT3 serotonin receptortarget
DB00370MirtazapineAlpha-2A adrenergic receptortarget
DB00370Mirtazapine5-hydroxytryptamine receptor 2Ctarget
DB00370MirtazapineKappa-type opioid receptortarget
DB00370MirtazapineHistamine H1 receptortarget
DB00370MirtazapineCytochrome P450 1A2enzyme
DB00370MirtazapineCytochrome P450 3A4enzyme
DB00370MirtazapineCytochrome P450 2D6enzyme
DB00370MirtazapineAlpha-1 adrenergic receptorstarget
DB00370MirtazapineSodium-dependent serotonin transportertransporter
DB01323St. John's WortMultidrug resistance protein 1transporter
DB01323St. John's WortCytochrome P450 3A4enzyme
DB01323St. John's WortCytochrome P450 2D6enzyme
DB01323St. John's WortCytochrome P450 2C19enzyme
DrugDrug NamePhaseStatusCount
DB00297Bupivacaine0Completed1
DB13975Cimicifuga racemosa1Terminated1
DB05052MF1011Unknown Status1
DB01065Melatonin1 / 2Terminated1
DB15458Norleucine1 / 2Completed1
DB00297Bupivacaine2Recruiting3
DB13975Cimicifuga racemosa2Completed2
DB13975Cimicifuga racemosa2Withdrawn1
DB00575Clonidine2Active Not Recruiting1
DB00286Conjugated estrogens2Completed1
DB00080Daptomycin2Completed1
DB06374Elacestrant2Completed1
DB06374Elacestrant2Terminated1
DB00668Epinephrine2Recruiting1
DB12235Estetrol2Completed1
DB00783Estradiol2Completed1
DB10708Flax seed2Completed1
DB00996Gabapentin2Active Not Recruiting1
DB00996Gabapentin2Completed1
DB05052MF1012Completed1
DB01377Magnesium oxide2Completed2
DB00603Medroxyprogesterone acetate2Completed1
DB01062Oxybutynin2Completed1
DB15264PD-02996852Completed1
DB00715Paroxetine2Completed1
DB00734Risperidone2Recruiting1
DB09153Sodium chloride2Recruiting3
DB01591Solifenacin2Active Not Recruiting1
DB01323St. John's Wort2Terminated1
DB00675Tamoxifen2Completed1
DB01708Prasterone2 / 3Completed1
DB11121Chloroxylenol3Completed1
DB13975Cimicifuga racemosa3Unknown Status1
DB00215Citalopram3Completed1
DB00286Conjugated estrogens3Completed1
DB04839Cyproterone acetate3Completed1
DB00783Estradiol3Completed3
DB00783Estradiol3Recruiting1
DB00996Gabapentin3Completed7
DB00014Goserelin3Recruiting1
DB05052MF1013Unknown Status1
DB00603Medroxyprogesterone acetate3Completed2
DB00351Megestrol acetate3Completed1
DB01062Oxybutynin3Completed1
DB00715Paroxetine3Completed1
DB01708Prasterone3Completed1
DB00230Pregabalin3Completed1
DB00396Progesterone3Active Not Recruiting1
DB00391Sulpiride3Completed1
DB09317Synthetic Conjugated Estrogens, A3Completed1
DB00624Testosterone3Active Not Recruiting1
DB00285Venlafaxine3Completed1
DB00285Venlafaxine3Terminated1
DB00297Bupivacaine4Not Yet Recruiting1
DB06700Desvenlafaxine4Recruiting1
DB00783Estradiol4Completed2
DB00996Gabapentin4Completed1
DB12007Isoflavone4Completed1
DB00007Leuprolide4Completed2
DB00367Levonorgestrel4Completed1
DB01224Quetiapine4Completed1
DB10388Salsola kali pollen4Completed1
DB14101Soy isoflavones4Completed1
DB09068Vortioxetine4Completed1
DB13975Cimicifuga racemosaNot AvailableCompleted1
DB00215CitalopramNot AvailableActive Not Recruiting1
DB00286Conjugated estrogensNot AvailableTerminated1
DB00286Conjugated estrogensNot AvailableUnknown Status1
DB01175EscitalopramNot AvailableActive Not Recruiting1
DB01175EscitalopramNot AvailableCompleted1
DB00783EstradiolNot AvailableUnknown Status1
DB00472FluoxetineNot AvailableEnrolling by Invitation1
DB00996GabapentinNot AvailableActive Not Recruiting1
DB00996GabapentinNot AvailableCompleted2
DB00715ParoxetineNot AvailableTerminated1
DB01104SertralineNot AvailableActive Not Recruiting1
DB00675TamoxifenNot AvailableActive Not Recruiting1
DB00285VenlafaxineNot AvailableActive Not Recruiting1
DB00285VenlafaxineNot AvailableCompleted2
DB00285VenlafaxineNot AvailableWithdrawn1
DB06684VilazodoneNot AvailableCompleted1
DB00425ZolpidemNot AvailableCompleted1