Dyslipidemia (Fredrickson Type Ⅱa)

Also known as: Familial Hypercholesterolaemia / Primary Hypercholesterolaemia / Type IIa hyperlipidaemia / Type IIa Hypercholesterolemia / Primary Hypercholesterolemia / Familial Hypercholesterolemia / Hypercholesterolemia, Familial / Type IIa hyperlipoproteinemia / Hyperlipoproteinemia Type IIa / Fredrickson Type IIa hyperlipoproteinemia / Type IIa hyperlipoproteinaemia / Fredrickson Type IIa hyperlipoproteinaemia / Fredrickson Type IIa hyperlipidemia / Fredrickson Type IIa hyperlipidaemia / Fredrickson Type IIa lipidemia / Fredrickson Type IIa lipidaemia / Type IIa hyperlipidemia / Type II lipidemia / Type II lipidaemia / Hyperlipoproteinemia Type II / Type II hyperlipoproteinaemia / Type II hyperlipoproteinemia / Fredrickson Type II hyperlipidaemia / Fredrickson Type II lipidemia / Fredrickson Type II hyperlipidemia / Type II hyperlipidaemia / Fredrickson Type II lipidaemia / Type II hyperlipidemia

DrugDrug NameDrug Description
DB01393BezafibrateAntilipemic agent that lowers cholesterol and triglycerides. It decreases low density lipoproteins and increases high density lipoproteins.
DB01432CholestyramineCholestyramine or colestyramine is a bile acid sequestrant. Bile acid sequestrants are polymeric compounds which serve as ion exchange resins. Cholestyramine resin is quite hydrophilic, but insoluble in water.
DB00375ColestipolBile acid sequestrants like colestipol have been in use since the 1970s.[FDA Label, F4555, F4567, L6262] And even though such an agent may very well be useful in reducing elevated cholesterol levels and decreasing the risk for atherosclerotic vascular disease due to hypercholesterolemia, colestipol is still generally only employed as an adjunct therapy and the relatively physical nature of its pharmacological activity sometimes limits its usefulness.[FDA Label, F4555, F4567, L6262] In particular, as colestipol's general mechanism of action ultimately results in the decreased absorption and enhanced secretion of bile acids and lipids in the feces, patients who take complicated medication regimens, experience constipation or biliary obstruction, etc. may not be good candidates for using the agent owing to its physical effects on the gut.[FDA Label, F4555, F4567, L6262] Alternatively, colestipol predominantly elicits its activities within the gut environment because it undergoes little absorption and metabolism.[FDA Label, F4555, F4567, L6262] The resultant lack of systemic exposure consequently means the medication generally demonstrates very few adverse effects inside the body.[FDA Label, F4555, F4567, L6262]
DB01039FenofibrateFenofibrate is a prodrug of fenofibric acid, an antilipemic agent which reduces both cholesterol and triglycerides in the blood.
DB01095FluvastatinFluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin belongs to a class of medications called statins and is used to reduce plasma cholesterol levels and prevent cardiovascular disease. It is also the first entirely synthetic HMG-CoA reductase inhibitor and is structurally distinct from the fungal derivatives of this therapeutic class. Fluvastatin is a racemate comprising equimolar amounts of (3R,5S)- and (3S,5R)-fluvastatin.
DrugDrug NameTargetType
DB01393BezafibratePeroxisome proliferator-activated receptor alphatarget
DB01393BezafibrateSolute carrier organic anion transporter family member 1B1transporter
DB01393BezafibratePeroxisome proliferator-activated receptor deltatarget
DB01393BezafibratePeroxisome proliferator-activated receptor gammatarget
DB01393BezafibrateCytochrome P450 1A1enzyme
DB01393BezafibrateCytochrome P450 2C8enzyme
DB01393BezafibrateCytochrome P450 3A4enzyme
DB01393BezafibrateNuclear receptor subfamily 1 group I member 2target
DB01393BezafibrateRetinoic acid receptor RXR-alphatarget
DB01393BezafibrateRetinoic acid receptor RXR-betatarget
DB01393BezafibrateRetinoic acid receptor RXR-gammatarget
DB01432CholestyramineBile acidstarget
DB00375ColestipolBile acidstarget
DB01039FenofibratePeroxisome proliferator-activated receptor alphatarget
DB01039FenofibrateMetalloproteinasetarget
DB01039FenofibrateCytochrome P450 2C8enzyme
DB01039FenofibrateCytochrome P450 2C9enzyme
DB01039FenofibrateCytochrome P450 3A4enzyme
DB01039FenofibratePeroxisome proliferator-activated receptor gammatarget
DB01039FenofibratePeroxisome proliferator-activated receptor deltatarget
DB01039FenofibrateNuclear receptor subfamily 1 group I member 2target
DB01039FenofibrateUDP-glucuronosyltransferase 1-1enzyme
DB01039FenofibrateBile salt export pumptransporter
DB01095Fluvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB01095FluvastatinCytochrome P450 2C9enzyme
DB01095FluvastatinCytochrome P450 3A4enzyme
DB01095FluvastatinCytochrome P450 2C8enzyme
DB01095FluvastatinCytochrome P450 2D6enzyme
DB01095FluvastatinCytochrome P450 2C19enzyme
DB01095FluvastatinCytochrome P450 1A1enzyme
DB01095FluvastatinSolute carrier organic anion transporter family member 1B1transporter
DB01095FluvastatinSolute carrier organic anion transporter family member 1B3transporter
DB01095FluvastatinSolute carrier organic anion transporter family member 2B1transporter
DB01095FluvastatinSolute carrier family 15 member 1transporter
DB01095FluvastatinCytochrome P450 3A5enzyme
DB01095FluvastatinUDP-glucuronosyltransferase 1-1enzyme
DB01095FluvastatinUDP-glucuronosyltransferase 1-3enzyme
DB01095FluvastatinUDP-glucuronosyltransferase 2B7enzyme
DB01095FluvastatinCanalicular multispecific organic anion transporter 1transporter
DB01095FluvastatinCytochrome P450 2B6enzyme
DrugDrug NamePhaseStatusCount
DB00945Acetylsalicylic acid1Completed1
DB01076Atorvastatin1Completed1
DB00758Clopidogrel1Completed1
DB01039Fenofibrate1Completed1
DB11629Laropiprant1Completed1
DB00140Riboflavin1 / 2Completed1
DB09145Water1 / 2Completed1
DB05035Eprotirome2Completed1
DB09303Evolocumab2Active Not Recruiting1
DB09303Evolocumab2Completed1
DB04852Implitapide2Terminated2
DB14901Inclisiran2Active Not Recruiting1
DB14901Inclisiran2Completed1
DB05528Mipomersen2Completed2
DB12433SCH-9002712Completed1
DB01076Atorvastatin3Active Not Recruiting1
DB01076Atorvastatin3Completed7
DB01432Cholestyramine3Completed1
DB00736Esomeprazole3Completed1
DB09303Evolocumab3Completed2
DB09303Evolocumab3Recruiting1
DB00973Ezetimibe3Completed5
DB00973Ezetimibe3Terminated1
DB08827Lomitapide3Completed1
DB09567Olive oil3Completed1
DB11133Omega-3 fatty acids3Completed1
DB08860Pitavastatin3Completed1
DB01098Rosuvastatin3Completed4
DB00641Simvastatin3Completed4
DB00641Simvastatin3Terminated2
DB06281Torcetrapib3Completed3
DB01076Atorvastatin4Completed1
DB00930Colesevelam4Completed1
DB09303Evolocumab4Not Yet Recruiting1
DB00973Ezetimibe4Completed1
DB09539Omega-3-acid ethyl esters4Unknown Status1
DB01098Rosuvastatin4Completed1
DB01098Rosuvastatin4Withdrawn1
DB00381AmlodipineNot AvailableCompleted1
DB01076AtorvastatinNot AvailableCompleted1
DB00169CholecalciferolNot AvailableUnknown Status1
DB00973EzetimibeNot AvailableCompleted3
DB01098RosuvastatinNot AvailableCompleted1
DB00133SerineNot AvailableCompleted2