Refractory Acute Lymphoblastic Leukemia (ALL)

Also known as: Acute Lymphoblastic Leukemia Refractory / Refractory Acute lymphoblastic leukaemia / Acute, refractory Lymphocytic Leukemia / Acute, refractory Lymphoblastic Leukemia / Acute lymphocytic leukemia refractory / Acute, refractory Lymphoblastic Leukaemia / Refractory Acute Lymphoblastic Leukemia / Acute lymphocytic leukaemia refractory / Acute Lymphoblastic Leukemia, Refractory / Acute, refractory Lymphocytic leukaemia / Leukemia Lymphocytic Acute (All) Refractory

DrugDrug NameDrug Description
DB00631ClofarabineA purine nucleoside used to treat relapsed or refractory acute lymphoblastic leukemia in patients 1 to 21 years old.
DB00619ImatinibA tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors.
DrugDrug NameTargetType
DB00631ClofarabineDNA polymerase alpha catalytic subunittarget
DB00631ClofarabineRibonucleoside-diphosphate reductase large subunittarget
DB00631ClofarabineDeoxycytidine kinaseenzyme
DB00631ClofarabineDNAtarget
DB00631ClofarabineATP-binding cassette sub-family G member 2transporter
DB00619ImatinibPlatelet-derived growth factor receptor betatarget
DB00619ImatinibTyrosine-protein kinase ABL1target
DB00619ImatinibMast/stem cell growth factor receptor Kittarget
DB00619ImatinibProto-oncogene tyrosine-protein kinase receptor Rettarget
DB00619ImatinibHigh affinity nerve growth factor receptortarget
DB00619ImatinibMacrophage colony-stimulating factor 1 receptortarget
DB00619ImatinibPlatelet-derived growth factor receptor alphatarget
DB00619ImatinibEpithelial discoidin domain-containing receptor 1target
DB00619ImatinibCytochrome P450 3A4enzyme
DB00619ImatinibBreakpoint cluster region proteintarget
DB00619ImatinibCytochrome P450 1A2enzyme
DB00619ImatinibCytochrome P450 2D6enzyme
DB00619ImatinibCytochrome P450 2C9enzyme
DB00619ImatinibCytochrome P450 2C19enzyme
DB00619ImatinibCytochrome P450 3A5enzyme
DB00619ImatinibCytochrome P450 3A7enzyme
DB00619ImatinibSolute carrier family 22 member 1transporter
DB00619ImatinibP-glycoprotein 1transporter
DB00619ImatinibSolute carrier family 22 member 2transporter
DB00619ImatinibATP-binding cassette sub-family G member 2transporter
DB00619ImatinibATP-binding cassette sub-family A member 3transporter
DB00619ImatinibSerum albumincarrier
DB00619ImatinibAlpha-1-acid glycoprotein 1carrier
DB00619ImatinibBile salt export pumptransporter
DB00619ImatinibCytochrome P450 2C8enzyme
DB00619ImatinibCanalicular multispecific organic anion transporter 1transporter
DB00619ImatinibMultidrug resistance-associated protein 1transporter
DB00619ImatinibSolute carrier family 22 member 5transporter
DB00619ImatinibSolute carrier organic anion transporter family member 1B3transporter
DB00619ImatinibMultidrug resistance-associated protein 4transporter
DB00619ImatinibSolute carrier organic anion transporter family member 1A2transporter
DB00619ImatinibDiscoidin domain-containing receptor 2target
DrugDrug NamePhaseStatusCount
DB01254Dasatinib0Recruiting1
DB00877Sirolimus0Terminated1
DB12001Abemaciclib1Terminated1
DB05812Abiraterone1Terminated1
DB08916Afatinib1Terminated1
DB00062Albumin human1Terminated1
DB00023Asparaginase Escherichia coli1Completed1
DB09495Avobenzone1Terminated1
DB00928Azacitidine1Recruiting1
DB00112Bevacizumab1Terminated1
DB01128Bicalutamide1Terminated1
DB00188Bortezomib1Recruiting1
DB00188Bortezomib1Terminated1
DB16741Bortezomib D-mannitol1Terminated1
DB06772Cabazitaxel1Terminated1
DB08875Cabozantinib1Terminated1
DB01101Capecitabine1Terminated1
DB00958Carboplatin1Terminated1
DB00482Celecoxib1Terminated1
DB05239Cobimetinib1Terminated1
DB09110Coenzyme M1Recruiting1
DB12483Copanlisib1Terminated1
DB00531Cyclophosphamide1Not Yet Recruiting1
DB00531Cyclophosphamide1Recruiting4
DB00531Cyclophosphamide1Unknown Status1
DB00987Cytarabine1Active Not Recruiting1
DB00987Cytarabine1Completed1
DB00987Cytarabine1Terminated1
DB08912Dabrafenib1Terminated1
DB11963Dacomitinib1Terminated1
DB12941Darolutamide1Terminated1
DB01254Dasatinib1Terminated1
DB00694Daunorubicin1Terminated1
DB01262Decitabine1Recruiting1
DB01234Dexamethasone1Completed1
DB01234Dexamethasone1Recruiting2
DB00997Doxorubicin1Completed1
DB00997Doxorubicin1Recruiting1
DB00997Doxorubicin1Terminated1
DB11714Durvalumab1Terminated1
DB13874Enasidenib1Terminated1
DB11986Entrectinib1Terminated1
DB08899Enzalutamide1Terminated1
DB00530Erlotinib1Terminated1
DB01590Everolimus1Terminated1
DB01073Fludarabine1Active Not Recruiting1
DB01073Fludarabine1Not Yet Recruiting1
DB01073Fludarabine1Recruiting4
DB01073Fludarabine1Suspended1
DB01073Fludarabine1Unknown Status1
DB00544Fluorouracil1Terminated1
DB00741Hydrocortisone1Completed1
DB09054Idelalisib1Terminated1
DB00619Imatinib1Terminated1
DB06186Ipilimumab1Terminated1
DB00480Lenalidomide1Unknown Status1
DB09078Lenvatinib1Terminated1
DB00650Leucovorin1Terminated1
DB12130Lorlatinib1Terminated1
DB00678Losartan1Terminated1
DB00888Mechlorethamine1Unknown Status1
DB00563Methotrexate1Completed1
DB00688Mycophenolate mofetil1Unknown Status1
DB15721Natural Killer Cell1Unknown Status1
DB11828Neratinib1Terminated1
DB09035Nivolumab1Terminated1
DB09496Octinoxate1Terminated1
DB09074Olaparib1Terminated1
DB00526Oxaliplatin1Terminated1
DB01229Paclitaxel1Terminated1
DB09073Palbociclib1Recruiting2
DB09073Palbociclib1Terminated1
DB06603Panobinostat1Terminated1
DB00059Pegaspargase1Completed1
DB16281Pegcrisantaspase1Active Not Recruiting1
DB09037Pembrolizumab1Terminated1
DB06366Pertuzumab1Terminated1
DB11759Pevonedistat1Completed1
DB08901Ponatinib1Terminated1
DB08896Regorafenib1Terminated1
DB00073Rituximab1Unknown Status1
DB08877Ruxolitinib1Terminated1
DB14797SEphB4-HSA1Terminated1
DB11942Selinexor1Active Not Recruiting1
DB00877Sirolimus1Terminated1
DB00398Sorafenib1Recruiting1
DB00398Sorafenib1Terminated1
DB01268Sunitinib1Terminated1
DB00864Tacrolimus1Unknown Status1
DB08911Trametinib1Terminated1
DB05773Trastuzumab emtansine1Terminated1
DB00755Tretinoin1Terminated1
DB08881Vemurafenib1Terminated1
DB11581Venetoclax1Terminated1
DB00541Vincristine1Completed1
DB00541Vincristine1Terminated1
DB08828Vismodegib1Terminated1
DB02546Vorinostat1Terminated1
DB08886Asparaginase Erwinia chrysanthemi1 / 2Recruiting1
DB00023Asparaginase Escherichia coli1 / 2Recruiting1
DB00928Azacitidine1 / 2Completed1
DB09052Blinatumomab1 / 2Recruiting2
DB14730Calaspargase pegol1 / 2Recruiting1
DB09110Coenzyme M1 / 2Active Not Recruiting1
DB09110Coenzyme M1 / 2Completed1
DB14681Cortisone1 / 2Completed1
DB00531Cyclophosphamide1 / 2Active Not Recruiting1
DB00531Cyclophosphamide1 / 2Completed1
DB00531Cyclophosphamide1 / 2Recruiting2
DB00091Cyclosporine1 / 2Suspended1
DB00987Cytarabine1 / 2Completed1
DB00987Cytarabine1 / 2Recruiting1
DB01254Dasatinib1 / 2Recruiting1
DB01234Dexamethasone1 / 2Active Not Recruiting1
DB01234Dexamethasone1 / 2Completed1
DB01234Dexamethasone1 / 2Recruiting1
DB14844Dordaviprone1 / 2Recruiting1
DB00773Etoposide1 / 2Recruiting1
DB00099Filgrastim1 / 2Completed1
DB00099Filgrastim1 / 2Recruiting1
DB01073Fludarabine1 / 2Active Not Recruiting1
DB01073Fludarabine1 / 2Recruiting1
DB01073Fludarabine1 / 2Suspended1
DB00741Hydrocortisone1 / 2Recruiting1
DB00650Leucovorin1 / 2Completed1
DB00650Leucovorin1 / 2Recruiting1
DB01033Mercaptopurine1 / 2Recruiting1
DB16620Methopterin1 / 2Completed1
DB00563Methotrexate1 / 2Completed1
DB00563Methotrexate1 / 2Recruiting1
DB00723Methoxamine1 / 2Completed1
DB00959Methylprednisolone1 / 2Completed1
DB00075Muromonab1 / 2Recruiting1
DB00688Mycophenolate mofetil1 / 2Recruiting1
DB00688Mycophenolate mofetil1 / 2Suspended1
DB12340Navitoclax1 / 2Recruiting1
DB00059Pegaspargase1 / 2Recruiting1
DB09037Pembrolizumab1 / 2Recruiting1
DB08901Ponatinib1 / 2Active Not Recruiting1
DB01263Posaconazole1 / 2Completed1
DB00635Prednisone1 / 2Completed1
DB00073Rituximab1 / 2Active Not Recruiting1
DB00073Rituximab1 / 2Completed1
DB00864Tacrolimus1 / 2Recruiting1
DB15044Tafasitamab1 / 2Recruiting1
DB11581Venetoclax1 / 2Active Not Recruiting1
DB11581Venetoclax1 / 2Completed1
DB11581Venetoclax1 / 2Recruiting2
DB00541Vincristine1 / 2Completed1
DB00541Vincristine1 / 2Recruiting2
DB00582Voriconazole1 / 2Completed1
DB17172Activated natural killer cell therapy2Recruiting1
DB13906Aloe vera leaf2Completed1
DB13906Aloe vera leaf2Recruiting1
DB09312Antilymphocyte immunoglobulin (horse)2Completed1
DB00098Antithymocyte immunoglobulin (rabbit)2Completed1
DB00126Ascorbic acid2Completed1
DB00126Ascorbic acid2Recruiting1
DB00023Asparaginase Escherichia coli2Recruiting1
DB11105Benzalkonium2Recruiting1
DB02379Beta-D-Glucose2Completed1
DB02379Beta-D-Glucose2Recruiting1
DB09052Blinatumomab2Active Not Recruiting2
DB09052Blinatumomab2Recruiting1
DB00188Bortezomib2Recruiting1
DB16741Bortezomib D-mannitol2Recruiting1
DB01008Busulfan2Completed1
DB01008Busulfan2Recruiting1
DB17465CD-16 NK-92 cells2Recruiting1
DB14730Calaspargase pegol2Recruiting1
DB14531Carbonate ion2Recruiting1
DB00631Clofarabine2Completed1
DB06189Clofarabine2Completed1
DB00631Clofarabine2Recruiting2
DB14681Cortisone2Active Not Recruiting1
DB14681Cortisone2Completed1
DB14681Cortisone2Recruiting1
DB00531Cyclophosphamide2Active Not Recruiting2
DB00531Cyclophosphamide2Completed2
DB00531Cyclophosphamide2Recruiting2
DB00987Cytarabine2Active Not Recruiting1
DB00987Cytarabine2Completed1
DB00987Cytarabine2Recruiting2
DB01254Dasatinib2Active Not Recruiting1
DB01254Dasatinib2Terminated1
DB00694Daunorubicin2Completed2
DB01234Dexamethasone2Recruiting1
DB00997Doxorubicin2Completed1
DB00898Ethanol2Recruiting1
DB00773Etoposide2Completed1
DB00773Etoposide2Recruiting1
DB00099Filgrastim2Active Not Recruiting1
DB00099Filgrastim2Completed1
DB00099Filgrastim2Recruiting1
DB15223Flotetuzumab2Withdrawn1
DB01073Fludarabine2Active Not Recruiting1
DB01073Fludarabine2Completed1
DB01073Fludarabine2Recruiting2
DB09462Glycerin2Completed1
DB09462Glycerin2Recruiting1
DB00741Hydrocortisone2Recruiting1
DB14545Hydrocortisone succinate2Recruiting1
DB09054Idelalisib2Terminated1
DB05889Inotuzumab ozogamicin2Terminated1
DB00888Mechlorethamine2Completed1
DB00888Mechlorethamine2Recruiting1
DB01033Mercaptopurine2Active Not Recruiting1
DB16620Methopterin2Active Not Recruiting3
DB16620Methopterin2Recruiting2
DB00563Methotrexate2Active Not Recruiting3
DB00563Methotrexate2Recruiting2
DB00959Methylprednisolone2Active Not Recruiting1
DB00959Methylprednisolone2Completed1
DB00959Methylprednisolone2Recruiting1
DB00075Muromonab2Active Not Recruiting2
DB00075Muromonab2Recruiting1
DB00688Mycophenolate mofetil2Active Not Recruiting1
DB00688Mycophenolate mofetil2Completed1
DB15721Natural Killer Cell2Recruiting1
DB02701Nicotinamide2Completed1
DB02701Nicotinamide2Recruiting1
DB06650Ofatumumab2Completed1
DB06650Ofatumumab2Recruiting1
DB11697Pacritinib2Terminated1
DB00019Pegfilgrastim2Active Not Recruiting1
DB00019Pegfilgrastim2Recruiting1
DB08901Ponatinib2Active Not Recruiting1
DB08901Ponatinib2Recruiting1
DB08901Ponatinib2Terminated1
DB00860Prednisolone2Recruiting1
DB00635Prednisone2Active Not Recruiting1
DB00635Prednisone2Completed1
DB00635Prednisone2Recruiting1
DB18515Revumenib2Recruiting1
DB00073Rituximab2Active Not Recruiting1
DB00073Rituximab2Completed2
DB00073Rituximab2Recruiting2
DB08877Ruxolitinib2Terminated1
DB00398Sorafenib2Terminated1
DB14546Sulfate ion2Active Not Recruiting1
DB14546Sulfate ion2Completed1
DB14546Sulfate ion2Recruiting1
DB01268Sunitinib2Terminated1
DB00864Tacrolimus2Active Not Recruiting1
DB00864Tacrolimus2Completed1
DB04572Thiotepa2Active Not Recruiting1
DB03754Tromethamine2Active Not Recruiting1
DB00541Vincristine2Active Not Recruiting2
DB00541Vincristine2Completed1
DB00541Vincristine2Recruiting2
DB00162Vitamin A2Completed1
DB00162Vitamin A2Recruiting1