Also known as: Gliomas / Glioma / [M]Glioma NOS
DrugDrug NameDrug Description
DB09054IdelalisibIdelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination with rituximab in patients for whom rituximab alone would be considered appropriate therapy due to other co-morbidities, while in the treatment of FL and SLL it is intended to be used in patients who have received at least two prior systemic therapies. More specifically, idelalisib targets P110δ, the delta isoform of the enzyme phosphatidylinositol-4,5-bisphosphate 3-kinase, also known as PI-3K. The PI-3Ks are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. In contrast to the other class IA PI3Ks p110α and p110β, p110δ is principally expressed in leukocytes (white blood cells) and is important for the function of T cells, B cell, mast cells and neutrophils. By inhibiting this enzyme, idelalisib induces apoptosis of malignant cells and inhibits several cell signaling pathways, including B-cell receptor (BCR) signaling and C-X-C chemokine receptors type 5 and type 4 signalling, which are involved in trafficking and homing of B-cells to the lymph nodes and bone marrow. Treatment of lymphoma cells with idelalisib has been shown to result in inhibition of chemotaxis and adhesion, and reduced cell viability.
DrugDrug NamePhaseStatusCount
DB00958Carboplatin0Terminated1
DB00531Cyclophosphamide0Recruiting1
DB01041Thalidomide0Recruiting1
DB01030Topotecan0Recruiting1
DB00862Vardenafil0Terminated1
DB00855Aminolevulinic acid1Terminated1
DB12318BMS-5996261Completed1
DB00112Bevacizumab1Completed1
DB00112Bevacizumab1Recruiting1
DB01101Capecitabine1Completed1
DB00958Carboplatin1Completed1
DB00482Celecoxib1Suspended1
DB05759Cixutumumab1Withdrawn1
DB05923Diazepinomicin1Completed1
DB12420Diazepinomicin1Completed1
DB00997Doxorubicin1Recruiting1
DB00773Etoposide1Recruiting1
DB01095Fluvastatin1Suspended1
DB12091Gadolinium1Not Yet Recruiting1
DB11911Galunisertib1Active Not Recruiting1
DB12827Indoximod1Recruiting1
DB00762Irinotecan1Completed1
DB00762Irinotecan1Recruiting1
DB01097Leflunomide1Completed1
DB01206Lomustine1Active Not Recruiting1
DB00220Nelfinavir1Active Not Recruiting1
DB06603Panobinostat1Recruiting1
DB05920RTA 7441Completed1
DB13045Racotumomab1Completed1
DB11730Ribociclib1Recruiting1
DB00533Rofecoxib1Terminated1
DB06176Romidepsin1Recruiting1
DB00020Sargramostim1Recruiting1
DB00877Sirolimus1Active Not Recruiting1
DB00853Temozolomide1Recruiting2
DB06287Temsirolimus1Withdrawn1
DB01030Topotecan1Not Yet Recruiting1
DB00313Valproic Acid1Withdrawn1
DB11930Varlilumab1Recruiting1
DB05428motexafin gadolinium1Completed1
DB00112Bevacizumab1 / 2Recruiting1
DB00958Carboplatin1 / 2Recruiting1
DB00608Chloroquine1 / 2Recruiting1
DB00987Cytarabine1 / 2Terminated1
DB01262Decitabine1 / 2Terminated1
DB12873Dianhydrogalactitol1 / 2Completed1
DB13874Enasidenib1 / 2Completed1
DB11911Galunisertib1 / 2Completed1
DB12827Indoximod1 / 2Recruiting1
DB00331Metformin1 / 2Recruiting1
DB11689Selumetinib1 / 2Recruiting1
DB09143Sonidegib1 / 2Completed1
DB00853Temozolomide1 / 2Completed1
DB00853Temozolomide1 / 2Recruiting1
DB00853Temozolomide1 / 2Terminated1
DB12218AZD-53632Recruiting1
DB08916Afatinib2Completed1
DB08916Afatinib2Recruiting1
DB00855Aminolevulinic acid2Terminated1
DB00855Aminolevulinic acid2Withdrawn1
DB00673Aprepitant2Recruiting1
DB00112Bevacizumab2Active Not Recruiting2
DB00112Bevacizumab2Completed3
DB00112Bevacizumab2Enrolling by Invitation1
DB00112Bevacizumab2Recruiting2
DB00112Bevacizumab2Unknown Status1
DB00188Bortezomib2Completed1
DB00958Carboplatin2Recruiting1
DB00262Carmustine2Completed1
DB00493Cefotaxime2Recruiting1
DB11890Cilengitide2Terminated1
DB11832Crenolanib2Terminated1
DB08865Crizotinib2Recruiting1
DB00531Cyclophosphamide2Recruiting1
DB08912Dabrafenib2Recruiting1
DB01254Dasatinib2Recruiting1
DB12873Dianhydrogalactitol2Recruiting2
DB00530Erlotinib2Recruiting1
DB00773Etoposide2Recruiting1
DB01590Everolimus2Active Not Recruiting1
DB01590Everolimus2Completed1
DB06717Fosaprepitant2Recruiting1
DB00762Irinotecan2Completed3
DB00762Irinotecan2Terminated1
DB00160L-Alanine2Terminated1
DB00160L-Alanine2Unknown Status2
DB05918LS112Completed1
DB01259Lapatinib2Completed2
DB09078Lenvatinib2Completed1
DB04868Nilotinib2Recruiting1
DB09035Nivolumab2Recruiting1
DB00904Ondansetron2Recruiting1
DB09330Osimertinib2Recruiting1
DB09073Palbociclib2Recruiting1
DB06589Pazopanib2Completed1
DB00008Peginterferon alfa-2a2Completed1
DB09037Pembrolizumab2Recruiting1
DB06366Pertuzumab2Recruiting1
DB11942Selinexor2Recruiting1
DB11689Selumetinib2Recruiting1
DB00203Sildenafil2Recruiting1
DB00398Sorafenib2Recruiting1
DB01268Sunitinib2Recruiting1
DB00675Tamoxifen2Completed1
DB00853Temozolomide2Active Not Recruiting1
DB00853Temozolomide2Completed7
DB00853Temozolomide2Recruiting4
DB00853Temozolomide2Terminated2
DB00853Temozolomide2Unknown Status2
DB01041Thalidomide2Completed2
DB09499Thiosulfuric acid2Recruiting1
DB08911Trametinib2Recruiting1
DB05773Trastuzumab emtansine2Recruiting1
DB00313Valproic Acid2Recruiting1
DB00570Vinblastine2Active Not Recruiting1
DB00570Vinblastine2Completed1
DB08828Vismodegib2Recruiting1
DB05299keyhole limpet hemocyanin2Enrolling by Invitation1
DB00822Disulfiram2 / 3Recruiting1
DB00855Aminolevulinic acid3Recruiting1
DB12873Dianhydrogalactitol3Recruiting1
DB00160L-Alanine3Recruiting1
DB05477MUC1 Dendritic Cell Vaccine3Active Not Recruiting1
DB00302Tranexamic Acid3Unknown Status1
DB01202Levetiracetam4Not Yet Recruiting1
DB00313Valproic Acid4Not Yet Recruiting1
DB00855Aminolevulinic acidNot AvailableRecruiting1
DB00112BevacizumabNot AvailableCompleted1
DB10583Clostridium tetani toxoid antigen (formaldehyde inactivated)Not AvailableRecruiting1
DB00633DexmedetomidineNot AvailableRecruiting1
DB00125L-ArginineNot AvailableRecruiting1
DB00683MidazolamNot AvailableRecruiting1
DB09037PembrolizumabNot AvailableRecruiting1
DB00818PropofolNot AvailableRecruiting1
DB00853TemozolomideNot AvailableCompleted2