Bacterial Vaginosis (BV)

Also known as: Bacterial Vaginosis / Vaginosis, Bacterial / Vaginosis bacterial / Vaginitis bacterial / Vaginosis bacterial NOS / Vaginitis bacterial NOS / Non-specific vaginitis

DrugDrug NameDrug Description
DB01190ClindamycinClindamycin is a semisynthetic lincosamide antibiotic that has largely replaced lincomycin due to an improved side effect profile. Clindamycin inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits. It may be bacteriostatic or bactericidal depending on the organism and drug concentration.
DB00916MetronidazoleA nitroimidazole used to treat amebiasis; vaginitis; trichomonas infections; giardiasis; anaerobic bacteria; and treponemal infections. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).
DB12834SecnidazoleSecnidazole is a second-generation 5-nitroimidazole antimicrobial that is structurally related to other 5-nitroimidazoles including [DB00916] and [DB00911], but displays improved oral absorption and longer terminal elimination half-life than antimicrobial agents in this class [A27210]. Secnidazole is selective against many anaerobic Gram-positive and Gram-negative bacteria and protozoa. In September 2017, FDA granted approval to secnidazole under the market name Solosec as a single-dose oral treatment for bacterial vaginosis, which is a common vaginal infection in women aged 15 to 44 years. The antimicrobial therapy is only intended to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria [FDA Label].
DB00911TinidazoleA nitroimidazole antitrichomonal agent effective against Trichomonas vaginalis, Entamoeba histolytica, and Giardia lamblia infections. [PubChem]
DrugDrug NamePhaseStatusCount
DB00916Metronidazole0Suspended1
DB00916Metronidazole0Unknown Status1
DB00911Tinidazole0Completed1
DB00916Metronidazole1Completed1
DB00916Metronidazole1 / 2Completed1
DB00916Metronidazole1 / 2Terminated1
DB05658Astodrimer2Completed1
DB09341Dextrose, unspecified form2Recruiting1
DB00916Metronidazole2Completed1
DB00916Metronidazole2Recruiting1
DB12834Secnidazole2Completed1
DB09153Sodium Chloride2Recruiting1
DB11326Boric acid2 / 3Completed1
DB00916Metronidazole2 / 3Completed1
DB00916Metronidazole2 / 3Unknown Status2
DB00681Amphotericin B3Unknown Status1
DB11854Astodrimer3Completed4
DB01190Clindamycin3Completed1
DB01190Clindamycin3Unknown Status1
DB11615Dequalinium3Completed1
DB01234Dexamethasone3Unknown Status1
DB01026Ketoconazole3Unknown Status1
DB00916Metronidazole3Completed4
DB00916Metronidazole3Unknown Status1
DB12834Secnidazole3Completed2
DB00759Tetracycline3Unknown Status1
DB00911Tinidazole3Completed1
DB00207Azithromycin4Completed1
DB01190Clindamycin4Completed1
DB01190Clindamycin4Recruiting2
DB00257Clotrimazole4Recruiting1
DB00977Ethinyl Estradiol4Active Not Recruiting1
DB00977Ethinyl Estradiol4Recruiting1
DB00977Ethinyl Estradiol4Unknown Status1
DB00294Etonogestrel4Active Not Recruiting1
DB00294Etonogestrel4Recruiting1
DB00294Etonogestrel4Unknown Status1
DB00916Metronidazole4Completed4
DB00916Metronidazole4Recruiting3
DB00916Metronidazole4Terminated1
DB00916Metronidazole4Unknown Status1
DB01110Miconazole4Recruiting1
DB00994Neomycin4Recruiting1
DB00857Terbinafine4Recruiting1
DB00911Tinidazole4Completed1
DB00916MetronidazoleNot AvailableCompleted5
DB00916MetronidazoleNot AvailableTerminated1
DB01110MiconazoleNot AvailableCompleted1
DB00577ValaciclovirNot AvailableWithdrawn1