Dry Eye Syndrome (DES)

Also known as: Dry Eye Syndrome / Dry Eye Disease (DED) / Dry Eye Disease / Dry Eye Syndromes / Tear film insufficiency, NOS / Gritty eye / Dry eye / Eyes dry / Tear film insufficiency, unspecified / Dry eye NOS / Dryness of eyes / Dry eyes / Eye dryness

DrugDrug NameDrug Description
DB00840Hydroxypropyl celluloseHydroxypropyl cellulose is an ether of cellulose where some of the hydroxyl groups of the cellulose have been hydroxypropylated forming -OCH2CH(OH)CH3 groups. Lacrisertis a formulation of hydroxypropyl cellulose that is used for artificial tears. It is used to treat syndromes characterized by insufficient tear production (keratoconjunctivitis sicca), recurrent corneal erosions, decreased corneal sensitivity, exposure and neuroparalytic keratitis, and as a lubricant for artificial eyes. As a food additive, hydroxypropyl cellulose is used as a thickener and as an emulsion stabilizer.
DB11611LifitegrastLifitegrast is a FDA approved drug for the treatment of keratoconjunctivitis sicca (dry eye syndrome). It is a tetrahydroisoquinoline derivative and lymphocyte function-associated antigen-1 ( LFA-1) antagonist that was discovered through the rational design process. The ophthalmic solution was approved in July, 2016 under the trade name Xiidra. It has shown to protect the corneal surface and alleviate the symptoms of dry eye syndrome with fast onset of action and well tolerated profile in both local and systemic setting [A18805].
DrugDrug NamePhaseStatusCount
DB09462Glycerin1Completed1
DB11075Hypromellose1Completed1
DB11077Polyethylene glycol 4001Completed1
DB11060Polyvinyl alcohol1Completed1
DB12058Recoflavone1Completed1
DB11059Carboxymethylcellulose2Completed1
DB13926Cenegermin2Completed1
DB13926Cenegermin2Recruiting1
DB00091Ciclosporin2Completed1
DB01234Dexamethasone2Completed1
DB06781Difluprednate2Completed1
DB05265Ecabet2Completed1
DB08818Hyaluronic acid2Completed1
DB12041Mapracorat2Completed1
DB00704Naltrexone2Completed1
DB12058Recoflavone2Completed1
DB12003Thymosin beta-42Completed1
DB00620Triamcinolone2Completed1
DB00091Ciclosporin2 / 3Completed1
DB12003Thymosin beta-42 / 3Completed1
DB11059Carboxymethylcellulose3Completed1
DB00091Ciclosporin3Completed1
DB00091Ciclosporin3Enrolling by Invitation1
DB00736Esomeprazole3Recruiting1
DB09462Glycerin3Completed1
DB08818Hyaluronic acid3Completed2
DB08818Hyaluronic acid3Recruiting1
DB11611Lifitegrast3Completed4
DB00959Methylprednisolone3Recruiting1
DB11656Rebamipide3Completed1
DB12003Thymosin beta-43Completed1
DB00207Azithromycin4Completed1
DB00963Bromfenac4Completed1
DB09301Chondroitin sulfate4Completed1
DB00091Ciclosporin4Completed2
DB00091Ciclosporin4Withdrawn1
DB01285Corticotropin4Recruiting1
DB09255Dextran4Withdrawn1
DB09462Glycerin4Completed1
DB09462Glycerin4Withdrawn1
DB08818Hyaluronic acid4Completed1
DB11075Hypromellose4Completed1
DB11075Hypromellose4Withdrawn1
DB00465Ketorolac4Completed1
DB00654Latanoprost4Completed1
DB00873Loteprednol4Completed2
DB00873Loteprednol4Withdrawn1
DB11057Mineral oil4Withdrawn1
DB09567Olive oil4Completed1
DB11058Petrolatum4Withdrawn1
DB11077Polyethylene glycol 4004Completed2
DB11077Polyethylene glycol 4004Withdrawn1
DB11060Polyvinyl alcohol4Completed2
DB11060Polyvinyl alcohol4Withdrawn1
DB11061Povidone4Withdrawn1
DB01839Propylene glycol4Completed1
DB00864Tacrolimus4Completed1
DB00287Travoprost4Completed1
DB01294Bismuth subsalicylateNot AvailableCompleted1
DB11059CarboxymethylcelluloseNot AvailableCompleted2
DB00091CiclosporinNot AvailableCompleted1
DB00091CiclosporinNot AvailableNot Yet Recruiting1
DB01234DexamethasoneNot AvailableCompleted1
DB09255DextranNot AvailableCompleted1
DB09462GlycerinNot AvailableCompleted4
DB11075HypromelloseNot AvailableCompleted3
DB00873LoteprednolNot AvailableUnknown Status1
DB11057Mineral oilNot AvailableCompleted1
DB11133Omega-3 fatty acidsNot AvailableActive Not Recruiting1
DB09539Omega-3-acid ethyl estersNot AvailableCompleted1
DB11058PetrolatumNot AvailableCompleted1
DB11077Polyethylene glycol 400Not AvailableCompleted4
DB11060Polyvinyl alcoholNot AvailableCompleted1
DB11061PovidoneNot AvailableCompleted1
DB11078Propylene glycolNot AvailableCompleted5
DB09153Sodium chlorideNot AvailableCompleted1
DB00684TobramycinNot AvailableNot Yet Recruiting1