Diabetes, Diabetes Mellitus Type 1

Also known as: TYPE 1 DIABETES / Type-1 Diabetes Mellitus / Diabetes Mellitus, Type 1 / Type 1 Diabetes Mellitis / Diabetes, Mellitus, Type 1 / Diabetes Mellitus Type I / Type I Diabetes Mellitus / Diabetes Mellitus: Type 1 / Type-1 Diabetes / Diabetics Mellitus Type 1 / Type 1 Diabetes Mellitus / Type 1 Diabetes Mellitus (T1DM) / Diabetes Mellitus, Type I / Type 1 Diabetes (T1D) / Type One Diabetes Mellitus / Diabetes Mellitus - Type 1 / Diabetes, Type 1 / Diabetes Mellitus Type 1 / Diabetes mellitus - juvenile / Diabetes mellitus juvenile onset / Ketosis-prone diabetes mellitus / Insulin-dependent diabetes mellitus / Diabetes mellitus insulin-dependent / Insulin dependent diabetic / Juvenile diabetes / IDDM

DrugDrug NameDrug Description
DB01306Insulin AspartInsulin aspart is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promotes glucose metabolism. Insulin is released from the pancreas following a meal to promote the uptake of glucose from the blood into internal organs and tissues such as the liver, fat cells, and skeletal muscle. Absorption of glucose into cells allows for its transformation into glycogen or fat for storage. Insulin also inhibits hepatic glucose production, enhances protein synthesis, and inhibits lipolysis and proteolysis among many other functions. Insulin is an important treatment in the management of Type 1 Diabetes (T1D) which is caused by an autoimmune reaction that destroys the beta cells of the pancreas, resulting in the body not being able to produce or synthesize the insulin needed to manage circulating blood sugar levels. As a result, people with T1D rely primarily on exogenous forms of insulin, such as insulin aspart, to lower glucose levels in the blood. Insulin is also used in the treatment of Type 2 Diabetes (T2D), another form of diabetes mellitus that is a slowly progressing metabolic disorder caused by a combination of genetic and lifestyle factors that promote chronically elevated blood sugar levels. Without treatment or improvement in non-pharmacological measures such as diet and exercise to lower blood glucose, high blood sugar eventually causes cellular resistance to endogenous insulin, and in the long term, damage to pancreatic islet cells. Insulin is typically prescribed later in the course of T2D, after trying several oral medications such as [DB00331], [DB01120], or [DB01261] have been tried, when sufficient damage has been caused to pancreatic cells that the body is no longer able to produce insulin on its own. Marketed as the brand name product NovoRapid, insulin aspart begins to exert its effects within 15 minutes of subcutaneous administration, while peak levels occur 30 to 90 minutes after administration. Due to its duration of action of around 5 hours, NovoRapid is considered "bolus insulin" as it provides high levels of insulin in a short period of time to mimic the release of endogenous insulin from the pancreas after meals. Bolus insulin is often combined with once daily, long-acting "basal insulin" such as [DB01307], [DB09564], and [DB00047] to provide low concentrations of background insulin that can keep blood sugar stable between meals or overnight. Use of basal and bolus insulin together is intended to mimic the pancreas' production of endogenous insulin, with a goal of avoiding any periods of hypoglycemia. Insulin aspart is a recombinant, biosynthetic, fast-acting insulin analogue. Compared to human insulin, it has a single amino acid substitution at position B28 where proline is replaced with aspartic acid. This substitution decreases its propensity to form hexamers and gives it a higher rate of absorption following subcutaneous administration compared to native insulin. Insulin aspart is produced in a genetically modified strain of _Saccharomyces cerevisiae_ (baker's yeast) Without an adequate supply of insulin to promote absorption of glucose from the bloodstream, blood sugar levels can climb to dangerously high levels and can result in symptoms such as fatigue, headache, blurred vision, and increased thirst. If left untreated, the body starts to break down fat, instead of glucose, for energy which results in a build-up of ketone acids in the blood and a syndrome called ketoacidosis, which is a life-threatening medical emergency. In the long term, elevated blood sugar levels increase the risk of heart attack, stroke, and diabetic neuropathy.
DB01307Insulin DetemirInsulin detemir is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promotes glucose metabolism. Insulin is released from the pancreas following a meal to promote the uptake of glucose from the blood into internal organs and tissues such as the liver, fat cells, and skeletal muscle. Absorption of glucose into cells allows for its transformation into glycogen or fat for storage. Insulin also inhibits hepatic glucose production, enhances protein synthesis, and inhibits lipolysis and proteolysis among many other functions. Insulin is an important treatment in the management of Type 1 Diabetes (T1D) which is caused by an autoimmune reaction that destroys the beta cells of the pancreas, resulting in the body not being able to produce or synthesize the insulin needed to manage circulating blood sugar levels. As a result, people with T1D rely primarily on exogenous forms of insulin, such as insulin detemir, to lower glucose levels in the blood. Insulin is also used in the treatment of Type 2 Diabetes (T2D), another form of diabetes mellitus that is a slowly progressing metabolic disorder caused by a combination of genetic and lifestyle factors that promote chronically elevated blood sugar levels. Without treatment or improvement in non-pharmacological measures such as diet and exercise to lower blood glucose, high blood sugar eventually causes cellular resistance to endogenous insulin, and in the long term, damage to pancreatic islet cells. Insulin is typically prescribed later in the course of T2D, after several oral medications such as [DB00331], [DB01120], or [DB01261] have been tried, when sufficient damage has been caused to pancreatic cells that the body is no longer able to produce insulin on its own. Marketed as the brand name product Levemir, insulin detemir has a duration of action of 16-24 hours allowing for once-daily dosing, typically at bedtime. Due to its duration of action, Levemir is considered "basal insulin" as it provides low concentrations of background insulin that can keep blood sugar stable between meals or overnight. Basal insulin is often combined with short-acting "bolus insulin" such as [DB00046], [DB01309], and [DB01306] to provide higher doses of insulin required following meals. Use of basal and bolus insulin together is intended to mimic the pancreas' production of endogenous insulin, with a goal of avoiding any periods of hypoglycemia. Insulin detemir is produced using recombinant DNA technology in yeast cells. This insulin analogue has a 14-C fatty acid, myristic acid, bound to the lysine amino acid at position B29. The myristoyl side chain increases self-association and albumin binding. This along with slow systemic absorption from the injection site prolongs distribution of the hormone into tissues and results in a long duration of action. Without an adequate supply of insulin to promote absorption of glucose from the bloodstream, blood sugar levels can climb to dangerously high levels and can result in symptoms such as fatigue, headache, blurred vision, and increased thirst. If left untreated, the body starts to break down fat, instead of glucose, for energy which results in a build-up of ketone acids in the blood and a syndrome called ketoacidosis, which is a life-threatening medical emergency. In the long term, elevated blood sugar levels increase the risk of heart attack, stroke, and diabetic neuropathy.
DB01309Insulin GlulisineInsulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promotes glucose metabolism. Insulin is released from the pancreas following a meal to promote the uptake of glucose from the blood into internal organs and tissues such as the liver, fat cells, and skeletal muscle. Absorption of glucose into cells allows for its transformation into glycogen or fat for storage. Insulin also inhibits hepatic glucose production, enhances protein synthesis, and inhibits lipolysis and proteolysis among many other functions. Insulin is an important treatment in the management of Type 1 Diabetes (T1D) which is caused by an autoimmune reaction that destroys the beta cells of the pancreas, resulting in the body not being able to produce or synthesize the insulin needed to manage circulating blood sugar levels. As a result, people with T1D rely primarily on exogenous forms of insulin, such as insulin glulisine, to lower glucose levels in the blood. Insulin is also used in the treatment of Type 2 Diabetes (T2D), another form of diabetes mellitus that is a slowly progressing metabolic disorder caused by a combination of genetic and lifestyle factors that promote chronically elevated blood sugar levels. Without treatment or improvement in non-pharmacological measures such as diet and exercise to lower blood glucose, high blood sugar eventually causes cellular resistance to endogenous insulin, and in the long term, damage to pancreatic islet cells. Insulin is typically prescribed later in the course of T2D, after trying several oral medications such as [DB00331], [DB01120], or [DB01261] have been tried, when sufficient damage has been caused to pancreatic cells that the body is no longer able to produce insulin on its own. Marketed as the brand name product Apidra, insulin glulisine begins to exert its effects within 15 minutes of subcutaneous administration, while peak levels occur 30 to 90 minutes after administration. Due to its duration of action of around 5 hours, Apidra is considered "bolus insulin" as it provides high levels of insulin in a short period of time to mimic the release of endogenous insulin from the pancreas after meals. Bolus insulin is often combined with once daily, long-acting "basal insulin" such as [DB01307], [DB09564], and [DB00047] to provide low concentrations of background insulin that can keep blood sugar stable between meals or overnight. Use of basal and bolus insulin together is intended to mimic the pancreas' production of endogenous insulin, with a goal of avoiding any periods of hypoglycemia. Insulin glulisine is a biosynthetic, rapid-acting human insulin analogue produced in a non-pathogenic laboratory strain of _Escherichia coli_ (K12). This recombinant hormone differs from native human insulin in that the amino acid arginine at position B3 is replaced by lysine and the lysine at position B29 is replaced by glutamic acid. These structural modifications decrease hexamer formation, stabilize insulin glulisine monomers and increase the rate of absorption and onset of action compared to human insulin. Without an adequate supply of insulin to promote absorption of glucose from the bloodstream, blood sugar levels can climb to dangerously high levels and can result in symptoms such as fatigue, headache, blurred vision, and increased thirst. If left untreated, the body starts to break down fat, instead of glucose, for energy which results in a build-up of ketone acids in the blood and a syndrome called ketoacidosis, which is a life-threatening medical emergency. In the long term, elevated blood sugar levels increase the risk of heart attack, stroke, and diabetic neuropathy.
DB00046Insulin LisproInsulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promotes glucose metabolism. Insulin is released from the pancreas following a meal to promote the uptake of glucose from the blood into internal organs and tissues such as the liver, fat cells, and skeletal muscle. Absorption of glucose into cells allows for its transformation into glycogen or fat for storage. Insulin also inhibits hepatic glucose production, enhances protein synthesis, and inhibits lipolysis and proteolysis among many other functions. Insulin is an important treatment in the management of Type 1 Diabetes (T1D) which is caused by an autoimmune reaction that destroys the beta cells of the pancreas, resulting in the body not being able to produce or synthesize the insulin needed to manage circulating blood sugar levels. As a result, people with T1D rely primarily on exogenous forms of insulin, such as insulin lispro, to lower glucose levels in the blood. Insulin is also used in the treatment of Type 2 Diabetes (T2D), another form of diabetes mellitus that is a slowly progressing metabolic disorder caused by a combination of genetic and lifestyle factors that promote chronically elevated blood sugar levels. Without treatment or improvement in non-pharmacological measures such as diet and exercise to lower blood glucose, high blood sugar eventually causes cellular resistance to endogenous insulin, and in the long term, damage to pancreatic islet cells. Insulin is typically prescribed later in the course of T2D, after trying several oral medications such as [DB00331], [DB01120], or [DB01261] have been tried, when sufficient damage has been caused to pancreatic cells that the body is no longer able to produce insulin on its own. Marketed as the brand name product Humalog, insulin lispro begins to exert its effects within 15 minutes of subcutaneous administration, while peak levels occur 30 to 90 minutes after administration. Due to its duration of action of around 5 hours, Humalog is considered "bolus insulin" as it provides high levels of insulin in a short period of time to mimic the release of endogenous insulin from the pancreas after meals. Bolus insulin is often combined with once daily, long-acting "basal insulin" such as [DB01307], [DB09564], and [DB00047] to provide low concentrations of background insulin that can keep blood sugar stable between meals or overnight. Use of basal and bolus insulin together is intended to mimic the pancreas' production of endogenous insulin, with a goal of avoiding any periods of hypoglycemia. Insulin lispro is produced by recombinant DNA technology utilizing a non-pathogenic laboratory strain of Escherichia coli and was the first commercially available insulin analog. Formerly called LYSPRO from the chemical nomenclature [LYS(B28), PRO(B29)], insulin lispro differs from human insulin in that the amino acid proline at position B28 is replaced by lysine and the lysine in position B29 is replaced by proline. These biochemical changes result in a reduced tendency for self-association and consequently rapid dissolution to a dimer and then to a monomer that is absorbed more rapidly after subcutaneous injection compared to human insulin. Without an adequate supply of insulin to promote absorption of glucose from the bloodstream, blood sugar levels can climb to dangerously high levels and can result in symptoms such as fatigue, headache, blurred vision, and increased thirst. If left untreated, the body starts to break down fat, instead of glucose, for energy which results in a build-up of ketone acids in the blood and a syndrome called ketoacidosis, which is a life-threatening medical emergency. In the long term, elevated blood sugar levels increase the risk of heart attack, stroke, and diabetic neuropathy.
DB00047Insulin glargineInsulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promotes glucose metabolism. Insulin is released from the pancreas following a meal to promote the uptake of glucose from the blood into internal organs and tissues such as the liver, fat cells, and skeletal muscle. Absorption of glucose into cells allows for its transformation into glycogen or fat for storage. Insulin also inhibits hepatic glucose production, enhances protein synthesis, and inhibits lipolysis and proteolysis. Insulin is an important treatment in the management of Type 1 Diabetes (T1D), which is caused by an autoimmune reaction that destroys the beta cells of the pancreas, resulting in the body not being able to produce or synthesize the insulin needed to manage circulating blood sugar levels. As a result, people with T1D rely primarily on exogenous forms of insulin, such as insulin glargine, to lower glucose levels in the blood. Insulin is also used in the treatment of Type 2 Diabetes (T2D), another form of diabetes mellitus that is a slowly progressing metabolic disorder caused by a combination of genetic and lifestyle factors that promote chronically elevated blood sugar levels. Without treatment or improvement in non-pharmacological measures such as diet and exercise to lower blood glucose, high blood sugar eventually causes cellular resistance to endogenous insulin, and in the long term, damage to pancreatic islet cells. Insulin is typically prescribed later in the course of T2D, after several oral medications such as [DB00331], [DB01120], or [DB01261] have been tried, when sufficient damage has been caused to pancreatic cells that the body is no longer able to produce insulin on its own. Available as the brand name product Lantus, insulin glargine has a duration of action up to 24 hours allowing for once-daily dosing, typically at bedtime. Due to its duration of action, Lantus is considered "basal insulin" as it provides low concentrations of background insulin that can keep blood sugar stable between meals or overnight. Basal insulin is often combined with short-acting "bolus insulin" such as [DB00046], [DB01309], and [DB01306] to provide higher doses of insulin that are required following meals. Use of basal and bolus insulin together is intended to mimic the pancreas' production of endogenous insulin, with a goal of avoiding any periods of hypoglycemia. Insulin glargine is also available as the biosimilar, or "follow-on" product, Basaglar in the US and as Abasaglar in the EU. As of 2015, insulin glargine was reformulated by Sanofi as the product Toujeo in an extra-concentrated form containing 300IU/mL (compared to 100IU/mL contained in Lantus). Use of the higher concentrated Toujeo as compared to Lantus results in slightly different pharmacokinetics, with a later onset (up to 6 hours) and duration of action (up to 30 hours). Insulin glargine is produced by recombinant DNA technology using a non-pathogenic laboratory strain of Escherichia coli (K12) as the production organism. Insulin glargine differs from endogenous human insulin by the replacement of an asparagine residue at position A21 of the A-chain with glycine and addition of two arginines to the C-terminus (positions B31 and 32) of the B-chain. The resulting protein is soluble at pH 4 and forms microprecipitates at physiological pH 7.4 allowing for the slow release of small amounts of insulin glargine, giving the drug a long duration of action and no pronounced peak concentration. Without an adequate supply of insulin to promote absorption of glucose from the bloodstream, blood sugar levels can climb to dangerously high levels and can result in symptoms such as fatigue, headache, blurred vision, and increased thirst. If left untreated, the body starts to break down fat, instead of glucose, for energy which results in a build-up of ketone acids in the blood and a syndrome called ketoacidosis, which is a life-threatening medical emergency. In the long term, elevated blood sugar levels increase the risk of heart attack, stroke, and diabetic neuropathy.
DB01278PramlintidePramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes.
DrugDrug NamePhaseStatusCount
DB00404Alprazolam0Completed1
DB00289Atomoxetine0Completed1
DB01216Finasteride0Recruiting1
DB00472Fluoxetine0Recruiting2
DB06674Golimumab0Recruiting1
DB00070Hyaluronidase (ovine)0Completed1
DB09564Insulin Degludec0Recruiting1
DB00047Insulin glargine0Recruiting1
DB06655Liraglutide0Completed1
DB06655Liraglutide0Recruiting1
DB01065Melatonin0Not Yet Recruiting1
DB01708Prasterone0Completed1
DB01708Prasterone0Recruiting1
DB09036Siltuximab0Completed1
DB06205Vorhyaluronidase alfa0Completed1
DB118982,4-thiazolidinedione1Completed1
DB14810AZD-16561Completed1
DB11704Adomeglivant1Completed1
DB00041Aldesleukin1Completed1
DB00058Alpha-1-proteinase inhibitor1Completed1
DB00058Alpha-1-proteinase inhibitor1Terminated1
DB01072Atazanavir1Completed1
DB01076Atorvastatin1Terminated1
DB12768BCG vaccine1Completed1
DB11121Chloroxylenol1Completed1
DB06292Dapagliflozin1Completed2
DB09341Dextrose, unspecified form1Completed2
DB09341Dextrose, unspecified form1Recruiting1
DB06243Eflornithine1Recruiting1
DB00153Ergocalciferol1Active Not Recruiting1
DB00199Erythromycin1Completed1
DB00783Estradiol1Withdrawn1
DB01276Exenatide1Completed1
DB14945Florbenazine F-181Suspended1
DB00040Glucagon1Completed5
DB00040Glucagon1Withdrawn1
DB01109Heparin1Completed1
DB14865Human interleukin-21Active Not Recruiting1
DB00741Hydrocortisone1Withdrawn1
DB01306Insulin Aspart1Completed35
DB01306Insulin Aspart1Recruiting1
DB09564Insulin Degludec1Completed20
DB01307Insulin Detemir1Completed5
DB01309Insulin Glulisine1Completed3
DB00030Insulin Human1Completed3
DB00030Insulin Human1Withdrawn1
DB00046Insulin Lispro1Completed23
DB00046Insulin Lispro1Recruiting1
DB00046Insulin Lispro1Terminated1
DB00046Insulin Lispro1Unknown Status1
DB00046Insulin Lispro1Withdrawn2
DB00047Insulin glargine1Completed23
DB11567Insulin peglispro1Completed7
DB11568Insulin tregopil1Terminated1
DB05098Leptin1Terminated1
DB06655Liraglutide1Completed1
DB06655Liraglutide1Withdrawn1
DB00603Medroxyprogesterone acetate1Withdrawn1
DB09046Metreleptin1Terminated1
DB05819NBI-60241Completed1
DB05496Otelixizumab1Completed1
DB00019Pegfilgrastim1Completed1
DB00082Pegvisomant1Withdrawn1
DB01132Pioglitazone1Completed1
DB01278Pramlintide1Completed4
DB06372Rilonacept1Completed1
DB05875Sar9, Met (O2)11-Substance P1Recruiting1
DB00877Sirolimus1Completed1
DB01261Sitagliptin1Completed2
DB09153Sodium chloride1Completed4
DB12713Sotagliflozin1Completed1
DB06606Teplizumab1Terminated1
DB00871Terbutaline1Completed1
DB11094Vitamin D1Active Not Recruiting1
DB06205Vorhyaluronidase alfa1Completed1
DB04963rhGAD651Active Not Recruiting1
DB06151Acetylcysteine1 / 2Completed1
DB00041Aldesleukin1 / 2Completed3
DB00041Aldesleukin1 / 2Not Yet Recruiting1
DB00087Alemtuzumab1 / 2Recruiting1
DB00058Alpha-1-proteinase inhibitor1 / 2Completed1
DB00345Aminohippuric acid1 / 2Recruiting1
DB00026Anakinra1 / 2Completed2
DB00026Anakinra1 / 2Recruiting1
DB00098Antithymocyte immunoglobulin (rabbit)1 / 2Active Not Recruiting2
DB00098Antithymocyte immunoglobulin (rabbit)1 / 2Completed1
DB00098Antithymocyte immunoglobulin (rabbit)1 / 2Not Yet Recruiting1
DB00098Antithymocyte immunoglobulin (rabbit)1 / 2Terminated1
DB06681Belatacept1 / 2Completed1
DB11748Benfotiamine1 / 2Completed1
DB06774Capsaicin1 / 2Recruiting1
DB00169Cholecalciferol1 / 2Recruiting1
DB00091Ciclosporin1 / 2Completed1
DB09341Dextrose, unspecified form1 / 2Unknown Status1
DB00095Efalizumab1 / 2Completed1
DB00095Efalizumab1 / 2Terminated1
DB00153Ergocalciferol1 / 2Recruiting1
DB00005Etanercept1 / 2Active Not Recruiting1
DB00005Etanercept1 / 2Completed2
DB00005Etanercept1 / 2Not Yet Recruiting1
DB00005Etanercept1 / 2Recruiting1
DB00005Etanercept1 / 2Withdrawn1
DB01590Everolimus1 / 2Completed1
DB01276Exenatide1 / 2Not Yet Recruiting1
DB00030Insulin Human1 / 2Completed1
DB00046Insulin Lispro1 / 2Completed2
DB01362Iohexol1 / 2Recruiting1
DB00951Isoniazid1 / 2Completed1
DB06655Liraglutide1 / 2Recruiting1
DB12406Lisofylline1 / 2Completed1
DB12406Lisofylline1 / 2Terminated1
DB05914Mesenchymal Stem Cells1 / 2Unknown Status1
DB00688Mycophenolate mofetil1 / 2Active Not Recruiting1
DB01024Mycophenolic acid1 / 2Completed1
DB01183Naloxone1 / 2Active Not Recruiting1
DB00704Naltrexone1 / 2Completed1
DB00019Pegfilgrastim1 / 2Active Not Recruiting1
DB00019Pegfilgrastim1 / 2Not Yet Recruiting1
DB06809Plerixafor1 / 2Recruiting1
DB00877Sirolimus1 / 2Active Not Recruiting1
DB00877Sirolimus1 / 2Completed1
DB00877Sirolimus1 / 2Terminated1
DB01261Sitagliptin1 / 2Completed1
DB09153Sodium chloride1 / 2Active Not Recruiting1
DB09153Sodium chloride1 / 2Completed1
DB00864Tacrolimus1 / 2Active Not Recruiting1
DB06606Teplizumab1 / 2Recruiting1
DB05679Ustekinumab1 / 2Active Not Recruiting1
DB11094Vitamin D1 / 2Recruiting1
DB09145Water1 / 2Withdrawn1
DB02530gamma-Aminobutyric acid1 / 2Recruiting1
DB06361rsPSMA Vaccine1 / 2Completed1
DB01281Abatacept2Completed2
DB01281Abatacept2Not Yet Recruiting1
DB01281Abatacept2Recruiting1
DB12497Alagebrium2Terminated1
DB00087Alemtuzumab2Completed2
DB00058Alpha-1-proteinase inhibitor2Recruiting1
DB00058Alpha-1-proteinase inhibitor2Terminated1
DB00058Alpha-1-proteinase inhibitor2Withdrawn1
DB06723Aluminum hydroxide2Completed1
DB00098Antithymocyte immunoglobulin (rabbit)2Active Not Recruiting1
DB00098Antithymocyte immunoglobulin (rabbit)2Recruiting1
DB00407Ardeparin2Withdrawn1
DB01076Atorvastatin2Completed1
DB09495Avobenzone2Completed1
DB00207Azithromycin2Recruiting1
DB00074Basiliximab2Completed2
DB00074Basiliximab2Recruiting1
DB00074Basiliximab2Withdrawn1
DB06681Belatacept2Completed2
DB01200Bromocriptine2Recruiting1
DB00136Calcitriol2Completed2
DB08907Canagliflozin2Completed1
DB06168Canakinumab2Completed1
DB00310Chlorthalidone2Not Yet Recruiting1
DB00169Cholecalciferol2Active Not Recruiting1
DB00091Ciclosporin2Withdrawn1
DB00111Daclizumab2Completed2
DB00111Daclizumab2Terminated1
DB00111Daclizumab2Withdrawn1
DB06292Dapagliflozin2Completed1
DB06292Dapagliflozin2Recruiting2
DB15226Dasiglucagon2Completed2
DB00746Deferoxamine2Recruiting1
DB12991Deoxyspergualin2Completed1
DB09341Dextrose, unspecified form2Completed1
DB00095Efalizumab2Completed1
DB00095Efalizumab2Withdrawn1
DB09038Empagliflozin2Completed3
DB09038Empagliflozin2Recruiting1
DB00584Enalapril2Completed1
DB00153Ergocalciferol2Active Not Recruiting1
DB00153Ergocalciferol2Completed1
DB00005Etanercept2Active Not Recruiting1
DB00005Etanercept2Completed2
DB00005Etanercept2Recruiting1
DB01276Exenatide2Active Not Recruiting1
DB01276Exenatide2Completed1
DB00973Ezetimibe2Completed1
DB01216Finasteride2Completed1
DB06062Gevokizumab2Completed2
DB00040Glucagon2Completed8
DB00040Glucagon2Not Yet Recruiting1
DB00040Glucagon2Recruiting1
DB00040Glucagon2Withdrawn2
DB06674Golimumab2Active Not Recruiting1
DB01109Heparin2Completed1
DB01109Heparin2Not Yet Recruiting1
DB01109Heparin2Withdrawn1
DB11064Homosalate2Completed1
DB14865Human interleukin-22Active Not Recruiting1
DB01050Ibuprofen2Completed1
DB00619Imatinib2Completed1
DB00065Infliximab2Completed1
DB01306Insulin Aspart2Completed5
DB01306Insulin Aspart2Withdrawn1
DB09564Insulin Degludec2Completed2
DB09564Insulin Degludec2Recruiting1
DB01307Insulin Detemir2Completed1
DB01309Insulin Glulisine2Completed1
DB00030Insulin Human2Completed4
DB00030Insulin Human2Recruiting1
DB00030Insulin Human2Withdrawn1
DB00046Insulin Lispro2Active Not Recruiting1
DB00046Insulin Lispro2Completed9
DB00046Insulin Lispro2Recruiting1
DB00046Insulin Lispro2Terminated1
DB00047Insulin glargine2Completed5
DB11567Insulin peglispro2Completed1
DB05258Interferon alfa2Unknown Status1
DB11698Ipragliflozin2Completed1
DB00448Lansoprazole2Terminated1
DB00448Lansoprazole2Unknown Status1
DB06655Liraglutide2Completed4
DB06655Liraglutide2Enrolling by Invitation3
DB06655Liraglutide2Recruiting1
DB06655Liraglutide2Terminated1
DB12406Lisofylline2Completed1
DB00678Losartan2Completed1
DB05914Mesenchymal Stem Cells2Active Not Recruiting1
DB00688Mycophenolate mofetil2Completed3
DB00688Mycophenolate mofetil2Withdrawn1
DB01024Mycophenolic acid2Withdrawn1
DB01183Naloxone2Recruiting1
DB11062Octisalate2Completed1
DB09535Octocrylene2Completed1
DB05496Otelixizumab2Completed1
DB05496Otelixizumab2Terminated2
DB12822Pancreatic Polypeptide2Unknown Status1
DB00213Pantoprazole2Completed1
DB00019Pegfilgrastim2Active Not Recruiting1
DB01278Pramlintide2Completed3
DB00571Propranolol2Recruiting1
DB00178Ramipril2Recruiting1
DB13973Remestemcel-L2Completed1
DB00073Rituximab2Completed1
DB00073Rituximab2Not Yet Recruiting1
DB00073Rituximab2Terminated1
DB01399Salsalate2Completed1
DB06335Saxagliptin2Completed1
DB09029Secukinumab2Terminated1
DB00641Simvastatin2Completed2
DB00877Sirolimus2Completed4
DB00877Sirolimus2Recruiting2
DB00877Sirolimus2Terminated1
DB00877Sirolimus2Withdrawn1
DB01261Sitagliptin2Completed2
DB01261Sitagliptin2Terminated1
DB01261Sitagliptin2Unknown Status1
DB09153Sodium chloride2Recruiting1
DB09153Sodium chloride2Unknown Status1
DB12713Sotagliflozin2Completed2
DB00864Tacrolimus2Completed5
DB00864Tacrolimus2Withdrawn1
DB08834Tauroursodeoxycholic acid2Active Not Recruiting1
DB06606Teplizumab2Completed1
DB06606Teplizumab2Terminated1
DB06273Tocilizumab2Active Not Recruiting1
DB05679Ustekinumab2Recruiting1
DB00661Verapamil2Active Not Recruiting1
DB04876Vildagliptin2Recruiting1
DB11094Vitamin D2Active Not Recruiting1
DB11094Vitamin D2Completed1
DB06205Vorhyaluronidase alfa2Completed3
DB09145Water2Recruiting1
DB04963rhGAD652Active Not Recruiting3
DB04963rhGAD652Completed4
DB04963rhGAD652Terminated1
DB00026Anakinra2 / 3Completed1
DB10520Cinnamon2 / 3Completed1
DB06292Dapagliflozin2 / 3Not Yet Recruiting1
DB15226Dasiglucagon2 / 3Recruiting1
DB12610Ebselen2 / 3Completed1
DB00153Ergocalciferol2 / 3Recruiting1
DB01276Exenatide2 / 3Completed1
DB01276Exenatide2 / 3Enrolling by Invitation1
DB00040Glucagon2 / 3Completed1
DB01016Glyburide2 / 3Completed1
DB00070Hyaluronidase (ovine)2 / 3Completed1
DB01306Insulin Aspart2 / 3Recruiting1
DB00046Insulin Lispro2 / 3Recruiting1
DB00047Insulin glargine2 / 3Completed1
DB06655Liraglutide2 / 3Active Not Recruiting1
DB06655Liraglutide2 / 3Completed1
DB06655Liraglutide2 / 3Enrolling by Invitation1
DB11829Ruboxistaurin2 / 3Completed1
DB01399Salsalate2 / 3Recruiting1
DB13928Semaglutide2 / 3Not Yet Recruiting1
DB09153Sodium chloride2 / 3Active Not Recruiting1
DB09153Sodium chloride2 / 3Completed1
DB09153Sodium chloride2 / 3Not Yet Recruiting1
DB06606Teplizumab2 / 3Completed1
DB06606Teplizumab2 / 3Terminated1
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DB11094Vitamin D2 / 3Recruiting1
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DB00074Basiliximab3Active Not Recruiting1
DB00074Basiliximab3Completed1
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DB00091Ciclosporin3Withdrawn2
DB06292Dapagliflozin3Completed4
DB06292Dapagliflozin3Recruiting1
DB15226Dasiglucagon3Completed3
DB15226Dasiglucagon3Recruiting1
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DB06651DiaPep 2773Terminated2
DB09038Empagliflozin3Completed2
DB00153Ergocalciferol3Completed1
DB00005Etanercept3Active Not Recruiting1
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DB01039Fenofibrate3Unknown Status1
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DB00040Glucagon3Unknown Status1
DB00065Infliximab3Completed1
DB01306Insulin Aspart3Completed29
DB01306Insulin Aspart3Recruiting3
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DB09564Insulin Degludec3Not Yet Recruiting1
DB09564Insulin Degludec3Recruiting1
DB01307Insulin Detemir3Completed23
DB01307Insulin Detemir3Recruiting2
DB01307Insulin Detemir3Terminated1
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DB01309Insulin Glulisine3Recruiting1
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DB00030Insulin Human3Terminated4
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DB00046Insulin Lispro3Completed11
DB00046Insulin Lispro3Not Yet Recruiting1
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DB00047Insulin glargine3Active Not Recruiting2
DB00047Insulin glargine3Completed20
DB00047Insulin glargine3Not Yet Recruiting1
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DB11567Insulin peglispro3Completed3
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DB06655Liraglutide3Recruiting4
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DB00491Miglitol3Completed1
DB00075Muromonab3Completed2
DB00338Omeprazole3Withdrawn1
DB05496Otelixizumab3Completed2
DB01278Pramlintide3Completed5
DB01278Pramlintide3Unknown Status1
DB00881Quinapril3Completed1
DB00178Ramipril3Terminated1
DB11829Ruboxistaurin3Completed1
DB06335Saxagliptin3Completed1
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DB12713Sotagliflozin3Completed3
DB00864Tacrolimus3Active Not Recruiting1
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DB06606Teplizumab3Completed1
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DB00437Allopurinol4Completed1
DB01076Atorvastatin4Completed1
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DB00169Cholecalciferol4Recruiting1
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DB01119Diazoxide4Recruiting1
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DB01276Exenatide4Recruiting1
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DB00597Gadoteridol4Completed1
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DB01306Insulin Aspart4Not Yet Recruiting1
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DB01307Insulin Detemir4Recruiting1
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DB01309Insulin Glulisine4Enrolling by Invitation1
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DB00073Rituximab4Unknown Status1
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DB09161Technetium Tc-99m sestamibi4Completed1
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DB00381AmlodipineNot AvailableCompleted1
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DB00074BasiliximabNot AvailableNo Longer Available1
DB06681BelataceptNot AvailableWithdrawn1
DB08907CanagliflozinNot AvailableActive Not Recruiting1
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DB01197CaptoprilNot AvailableRecruiting1
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DB00169CholecalciferolNot AvailableCompleted1
DB00091CiclosporinNot AvailableCompleted2
DB00257ClotrimazoleNot AvailableNo Longer Available1
DB00930ColesevelamNot AvailableCompleted1
DB01234DexamethasoneNot AvailableWithdrawn1
DB09341Dextrose, unspecified formNot AvailableCompleted1
DB09341Dextrose, unspecified formNot AvailableUnknown Status1
DB01225EnoxaparinNot AvailableNo Longer Available1
DB00668EpinephrineNot AvailableWithdrawn2
DB00153ErgocalciferolNot AvailableCompleted1
DB00016ErythropoietinNot AvailableCompleted1
DB00898EthanolNot AvailableActive Not Recruiting1
DB06215FerumoxytolNot AvailableUnknown Status1
DB14945Florbenazine F-18Not AvailableCompleted1
DB00687FludrocortisoneNot AvailableWithdrawn1
DB00472FluoxetineNot AvailableCompleted1
DB00983FormoterolNot AvailableCompleted1
DB00040GlucagonNot AvailableActive Not Recruiting1
DB00040GlucagonNot AvailableCompleted3
DB00040GlucagonNot AvailableSuspended1
DB00040GlucagonNot AvailableTerminated1
DB06674GolimumabNot AvailableAvailable1
DB01109HeparinNot AvailableNo Longer Available1
DB01306Insulin AspartNot AvailableCompleted21
DB01306Insulin AspartNot AvailableNot Yet Recruiting1
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DB09564Insulin DegludecNot AvailableActive Not Recruiting1
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DB01307Insulin DetemirNot AvailableActive Not Recruiting1
DB01307Insulin DetemirNot AvailableCompleted21
DB01307Insulin DetemirNot AvailableRecruiting1
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DB01309Insulin GlulisineNot AvailableCompleted2
DB00030Insulin HumanNot AvailableCompleted4
DB00030Insulin HumanNot AvailableTerminated1
DB00046Insulin LisproNot AvailableCompleted4
DB00046Insulin LisproNot AvailableRecruiting3
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DB00046Insulin LisproNot AvailableTerminated1
DB00047Insulin glargineNot AvailableCompleted1
DB00047Insulin glargineNot AvailableRecruiting1
DB00047Insulin glargineNot AvailableTerminated1
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DB02325Isopropyl alcoholNot AvailableActive Not Recruiting1
DB00583LevocarnitineNot AvailableCompleted1
DB00583LevocarnitineNot AvailableRecruiting1
DB08882LinagliptinNot AvailableRecruiting1
DB06655LiraglutideNot AvailableCompleted1
DB06655LiraglutideNot AvailableEnrolling by Invitation1
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DB01046LubiprostoneNot AvailableTerminated1
DB01277MecaserminNot AvailableCompleted1
DB05914Mesenchymal Stem CellsNot AvailableCompleted1
DB00563MethotrexateNot AvailableCompleted1
DB00968MethyldopaNot AvailableCompleted1
DB01110MiconazoleNot AvailableNo Longer Available1
DB00688Mycophenolate mofetilNot AvailableCompleted1
DB00688Mycophenolate mofetilNot AvailableNo Longer Available1
DB01024Mycophenolic acidNot AvailableCompleted1
DB01024Mycophenolic acidNot AvailableNo Longer Available1
DB01024Mycophenolic acidNot AvailableRecruiting1
DB00082PegvisomantNot AvailableCompleted1
DB00806PentoxifyllineNot AvailableNo Longer Available1
DB00556PerflutrenNot AvailableCompleted1
DB01278PramlintideNot AvailableCompleted4
DB00877SirolimusNot AvailableCompleted1
DB00877SirolimusNot AvailableNo Longer Available2
DB01261SitagliptinNot AvailableCompleted2
DB09153Sodium chlorideNot AvailableCompleted1
DB09153Sodium chlorideNot AvailableRecruiting1
DB09484Sodium fluorophosphateNot AvailableCompleted1
DB09099SomatostatinNot AvailableCompleted2
DB00052SomatotropinNot AvailableCompleted1
DB00421SpironolactoneNot AvailableRecruiting1
DB01015SulfamethoxazoleNot AvailableNo Longer Available1
DB00864TacrolimusNot AvailableCompleted1
DB00864TacrolimusNot AvailableNo Longer Available2
DB00857TerbinafineNot AvailableNo Longer Available1
DB00871TerbutalineNot AvailableCompleted1
DB08604TriclosanNot AvailableNo Longer Available1
DB00440TrimethoprimNot AvailableNo Longer Available1
DB01610ValganciclovirNot AvailableNo Longer Available1
DB11094Vitamin DNot AvailableCompleted1
DB08850gamma-Aminobutyric acidNot AvailableUnknown Status1