Fracture Bone

Also known as: Fractures / Fracture / Fracture, cause unspecified / Broken bones / Fracture of unspecified bones / Fractures, Bone / Fracture NOS / Abrasion NOS

DrugDrug NameDrug Description
DB00945Acetylsalicylic acidAlso known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial infarction (MI) [FDA label]. Interestingly, the results of various studies have demonstrated that long-term use of acetylsalicylic acid may decrease the risk of various cancers, including colorectal, esophageal, breast, lung, prostate, liver and skin cancer [A177325]. Aspirin is classified as a _non-selective cyclooxygenase (COX) inhibitor_ [A32682, A177268] and is available in many doses and forms, including chewable tablets, suppositories, extended release formulations, and others [L5968]. Acetylsalicylic acid is a very common cause of accidental poisoning in young children. It should be kept out of reach from young children, toddlers, and infants [FDA label].
DB06643DenosumabDenosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption markers in patients with a variety of metastatic tumors and is being investigated in multiple clinical trials for the prevention and treatment of bone metastases. Chemically, it consists of 2 heavy and 2 light chains. Each light chain consists of 215 amino acids. Each heavy chain consists of 448 amino acids with 4 intramolecular disulfides. FDA approved on June 1, 2010.
DrugDrug NameTargetType
DB00945Acetylsalicylic acidProstaglandin G/H synthase 1target
DB00945Acetylsalicylic acidProstaglandin G/H synthase 2target
DB00945Acetylsalicylic acidAldo-keto reductase family 1 member C1target
DB00945Acetylsalicylic acidSolute carrier family 22 member 6transporter
DB00945Acetylsalicylic acidMultidrug resistance protein 1transporter
DB00945Acetylsalicylic acidCytochrome P450 2C19enzyme
DB00945Acetylsalicylic acidCytochrome P450 2C9enzyme
DB00945Acetylsalicylic acid5'-AMP-activated protein kinasetarget
DB00945Acetylsalicylic acidEndothelin-1 receptortarget
DB00945Acetylsalicylic acidNuclear factor kappa b beta subunittarget
DB00945Acetylsalicylic acidCellular tumor antigen p53target
DB00945Acetylsalicylic acid78 kDa glucose-regulated proteintarget
DB00945Acetylsalicylic acidRibosomal protein S6 kinase alpha-3target
DB00945Acetylsalicylic acidNF-kappa-B inhibitor alphatarget
DB00945Acetylsalicylic acidTumor necrosis factor-inducible gene 6 proteintarget
DB00945Acetylsalicylic acidCaspase-1target
DB00945Acetylsalicylic acidCaspase-3target
DB00945Acetylsalicylic acidInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB00945Acetylsalicylic acidExtracellular signal-regulated kinase (ERK)target
DB00945Acetylsalicylic acidG1/S-specific cyclin-D1target
DB00945Acetylsalicylic acidMyc proto-oncogene proteintarget
DB00945Acetylsalicylic acidProliferating cell nuclear antigentarget
DB00945Acetylsalicylic acidCyclin Atarget
DB00945Acetylsalicylic acidUDP-glucuronosyltransferase 1-6enzyme
DB00945Acetylsalicylic acidArylamine N-acetyltransferase 2enzyme
DB00945Acetylsalicylic acidSolute carrier family 22 member 8transporter
DB06643DenosumabTumor necrosis factor ligand superfamily member 11target
DrugDrug NamePhaseStatusCount
DB00136Calcitriol2Active Not Recruiting1
DB00169Cholecalciferol2Active Not Recruiting1
DB00169Cholecalciferol2Recruiting1
DB11639Dibotermin alfa2Completed2
DB01356Lithium cation2Recruiting1
DB11639Dibotermin alfa2 / 3Terminated1
DB05581Teriparatide2 / 3Completed1
DB06285Teriparatide2 / 3Completed1
DB00945Acetylsalicylic acid3Active Not Recruiting1
DB00169Cholecalciferol3Active Not Recruiting1
DB00169Cholecalciferol3Unknown Status1
DB00153Ergocalciferol3Active Not Recruiting1
DB00153Ergocalciferol3Unknown Status1
DB00327Hydromorphone3Terminated1
DB01221Ketamine3Terminated1
DB00683Midazolam3Completed1
DB00539Toremifene3Completed1
DB11094Vitamin D3Active Not Recruiting1
DB11094Vitamin D3Unknown Status1
DB00316Acetaminophen4Completed1
DB00297Bupivacaine4Completed1
DB00297Bupivacaine4Withdrawn1
DB01373Calcium4Completed1
DB00668Epinephrine4Completed1
DB00153Ergocalciferol4Completed1
DB00292Etomidate4Unknown Status1
DB00813Fentanyl4Completed1
DB01050Ibuprofen4Completed1
DB00465Ketorolac4Completed1
DB00281Lidocaine4Completed1
DB00333Methadone4Unknown Status1
DB00683Midazolam4Unknown Status1
DB00295Morphine4Unknown Status1
DB00295Morphine4Withdrawn1
DB00497Oxycodone4Completed1
DB00818Propofol4Completed1
DB00818Propofol4Unknown Status1
DB00884Risedronic acid4Completed1
DB06285Teriparatide4Unknown Status1
DB00193Tramadol4Completed1
DB11094Vitamin D4Completed1
DB00399Zoledronic acid4Completed1
DB016325-O-phosphono-alpha-D-ribofuranosyl diphosphateNot AvailableRecruiting1
DB00316AcetaminophenNot AvailableUnknown Status1
DB00630Alendronic acidNot AvailableCompleted1
DB00318CodeineNot AvailableUnknown Status1
DB01050IbuprofenNot AvailableCompleted1
DB01050IbuprofenNot AvailableUnknown Status1
DB01221KetamineNot AvailableCompleted2
DB01221KetamineNot AvailableRecruiting1
DB00295MorphineNot AvailableRecruiting1
DB11133Omega-3 fatty acidsNot AvailableActive Not Recruiting1
DB09153Sodium chlorideNot AvailableRecruiting1
DB00302Tranexamic acidNot AvailableEnrolling by Invitation1