Heart Failure With Reduced Ejection Fraction (HFrEF)

Also known as: Heart Failure, Reduced Ejection Fraction / Heart Failure With Reduced Ejection Fraction (HF-rEF) / Reduced ejection fraction heart failure / Systolic Heart Failure / Heart Failure With Reduced Ejection Fraction / Heart Failure and Reduced Ejection Fraction / Heart failure / Weak heart / Failure heart / Heart failure (NOS) / Heart failures / Cardiac failure / Heart failure, unspecified / Cardiac failure NOS / Cardiac failure (NOS) / Cardiac insufficiency / Insufficiency cardiac / Cardiac function failure / Cardiac function failed / Heart insufficiency / Heart Failure, Systolic

DrugDrug NameDrug Description
DB00178RamiprilRamipril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to ramiprilat in the liver and, to a lesser extent, kidneys. Ramiprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Ramipril may be used in the treatment of hypertension, congestive heart failure, nephropathy, and to reduce the rate of death, myocardial infarction and stroke in individuals at high risk of cardiovascular events.
DrugDrug NamePhaseStatusCount
DB09038Empagliflozin2Recruiting1
DB11816Omecamtiv Mecarbil2Completed1
DB01032Probenecid2Completed1
DB01220Rifaximin2Recruiting1
DB00073Rituximab2Not Yet Recruiting1
DB09292Sacubitril2Completed1
DB00584Enalapril3Active Not Recruiting1
DB00584Enalapril3Terminated1
DB09292Sacubitril3Active Not Recruiting1
DB09292Sacubitril3Terminated1
DB06267Udenafil3Terminated1
DB01136Carvedilol4Recruiting1
DB00880Chlorothiazide4Enrolling by Invitation1
DB00758Clopidogrel4Completed1
DB00584Enalapril4Completed1
DB00584Enalapril4Recruiting1
DB00584Enalapril4Withdrawn1
DB00828Fosfomycin4Recruiting1
DB01592Iron4Recruiting1
DB00451Levothyroxine4Unknown Status1
DB00524Metolazone4Enrolling by Invitation1
DB06209Prasugrel4Completed1
DB09292Sacubitril4Completed2
DB09292Sacubitril4Recruiting1
DB09292Sacubitril4Withdrawn1
DB09153Sodium Chloride4Recruiting1
DB00177Valsartan4Completed1
DB00177Valsartan4Recruiting1
DB00177Valsartan4Withdrawn1
DB00661Verapamil4Unknown Status1
DB00612BisoprololNot AvailableActive Not Recruiting1
DB09083IvabradineNot AvailableActive Not Recruiting1
DB09292SacubitrilNot AvailableAvailable1
DB09292SacubitrilNot AvailableNot Yet Recruiting1
DB00177ValsartanNot AvailableNot Yet Recruiting1