Tremor, Essential

Also known as: Essential Tremor / Tremors, Essential / Essential tremor (hereditary) / Benign essential tremor / Familial tremor

DrugDrug NameDrug Description
DB01068ClonazepamA benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop [FDA Label] [L5572, F3763, F3787, F3796]. The agent has also been indicated for treating panic disorder [FDA Label] [A175438, L5572, F3763, F3787, F3796]. The mechanism of action appears to involve the enhancement of gamma-aminobutyric acid receptor responses [FDA Label] [A175438, A175441, L5572, F3763, F3787, F3796]. Since being first patented in 1960 and then released for sale from Roche in the US in 1975 [T469, T472], clonazepam has experienced a storied history in the treatment of the aforementioned medical conditions. Now available as a generic medication, the agent continues to see exceptionally high use as millions of prescriptions are written for the medication internationally every year. Unfortunately, however, like most benzodiazepines, clonazepam use has also been associated with recreational use and drug abuse [FDA Label] [L5572, F3763, F3787, F3796].
DB00794PrimidoneAn antiepileptic agent related to the barbiturates; it is partly metabolized to phenobarbital in the body and owes some of its actions to this metabolite. Adverse effects are reported to be more frequent than with phenobarbital. (From Martindale, The Extra Pharmacopoeia, 30th ed, p309)
DB00571PropranololPropranolol is a racemic mixture of 2 enantiomers where the S(-)-enantiomer has approximately 100 times the binding affinity for beta adrenergic receptors.[L6904] Propranolol is used to treat a number of conditions but most commonly is used for hypertension.[L6901,L6904,L6907] Propranolol was granted FDA approval on 13 November 1967.[L6904]
DB00273TopiramateTopiramate is a sulfamate-substituted monosaccharide with some activity against carbonic anhydrase.[A175225] It was conceived as part of the efforts to generate analogs of fructose-1,6-diphosphate to block gluconeogenesis in which topiramate was a synthetic intermediate. Analyzing its similarity to acetazolamide, researchers decided to study its capability as an anticonvulsant agent where was shown to be highly active against maximal electroshock seizure and to present a long duration of action.[A175249] Structurally, topiramate does not resemble a normal therapeutic agent as it presents a very high concentration of oxygen. The oxygen atoms in the topiramate molecule are expected to function as acceptors for hydrogen-bond formation while its amide group serves as an important hydrogen donor.[A175249] Topiramate has been approved in Europe since 2003, in the UK in 1995[A175243] and in the US since 2004. This drug has been approved for a number of conditions and in 2014 it was approved for the prevention of migraine in children.[A175231]
DrugDrug NameTargetType
DB01068ClonazepamTranslocator proteintarget
DB01068ClonazepamCytochrome P450 3A4enzyme
DB01068ClonazepamSerum albumincarrier
DB01068ClonazepamCytochrome P450 2E1enzyme
DB01068ClonazepamArylamine N-acetyltransferase 2enzyme
DB01068ClonazepamGABA-A receptor (anion channel)target
DB01068ClonazepamNuclear receptor subfamily 1 group I member 2target
DB00794PrimidoneGamma-aminobutyric acid receptor subunit alpha-1target
DB00794PrimidoneCytochrome P450 2C19enzyme
DB00794PrimidoneCytochrome P450 1A2enzyme
DB00794PrimidoneCytochrome P450 2B6enzyme
DB00794PrimidoneCytochrome P450 2C8enzyme
DB00794PrimidoneCytochrome P450 2C9enzyme
DB00794PrimidoneCytochrome P450 3A4enzyme
DB00794PrimidoneGamma-aminobutyric acid receptor subunit alpha-2target
DB00794PrimidoneGamma-aminobutyric acid receptor subunit alpha-3target
DB00794PrimidoneGamma-aminobutyric acid receptor subunit alpha-4target
DB00794PrimidoneGamma-aminobutyric acid receptor subunit alpha-5target
DB00794PrimidoneGamma-aminobutyric acid receptor subunit alpha-6target
DB00794PrimidoneNeuronal acetylcholine receptor subunit alpha-4target
DB00794PrimidoneNeuronal acetylcholine receptor subunit alpha-7target
DB00794PrimidoneGlutamate receptor 2target
DB00794PrimidoneGlutamate receptor ionotropic, kainate 2target
DB00794PrimidoneGABA-A receptor (anion channel)target
DB00794PrimidoneUDP-glucuronosyltransferase 1-1enzyme
DB00571PropranololBeta-1 adrenergic receptortarget
DB00571PropranololBeta-2 adrenergic receptortarget
DB00571PropranololBeta-3 adrenergic receptortarget
DB00571Propranolol5-hydroxytryptamine receptor 1Atarget
DB00571Propranolol5-hydroxytryptamine receptor 1Btarget
DB00571PropranololCytochrome P450 1A2enzyme
DB00571PropranololCytochrome P450 2D6enzyme
DB00571PropranololAlpha-1-acid glycoprotein 1carrier
DB00571PropranololCytochrome P450 2C19enzyme
DB00571PropranololCytochrome P450 3A4enzyme
DB00571PropranololCytochrome P450 3A5enzyme
DB00571PropranololCytochrome P450 3A7enzyme
DB00571PropranololSolute carrier family 22 member 2transporter
DB00571PropranololMultidrug resistance protein 1transporter
DB00571PropranololCytochrome P450 1A1enzyme
DB00571PropranololAmine oxidase [flavin-containing] Aenzyme
DB00571PropranololSerum albumincarrier
DB00273TopiramateGamma-aminobutyric acid receptor subunit alpha-1target
DB00273TopiramateSodium channel protein type 1 subunit alphatarget
DB00273TopiramateCarbonic anhydrase 2target
DB00273TopiramateCarbonic anhydrase 4target
DB00273TopiramateGlutamate receptor ionotropic, kainate 1target
DB00273TopiramateCytochrome P450 2C19enzyme
DB00273TopiramateCytochrome P450 3A4enzyme
DB00273TopiramateGABA-A receptor (anion channel)target
DB00273TopiramateCarbonic anhydrase 1target
DB00273TopiramateCarbonic anhydrase 3target
DB00273TopiramateGlutamate receptor 1target
DrugDrug NamePhaseStatusCount
DB04519Caprylic acid1Completed1
DB12452Caprylic alcohol1Completed2
DB09061Cannabidiol1 / 2Recruiting1
DB04519Caprylic acid1 / 2Completed1
DB00470Dronabinol1 / 2Recruiting1
DB01202Levetiracetam1 / 2Completed1
DB00083Botulinum toxin type A2Active Not Recruiting1
DB11859Brexanolone2Completed1
DB12452Caprylic alcohol2Completed2
DB08883Perampanel2Active Not Recruiting1
DB12621ST-1012Completed1
DB09072Sodium oxybate2Completed1
DB11654T-20002Terminated2
DB00909Zonisamide2Completed1
DB00633Dexmedetomidine2 / 3Withdrawn1
DB00413Pramipexole3Not Yet Recruiting1
DB00273Topiramate3Completed1
DB01043Memantine4Completed1
DB00230Pregabalin4Completed2
DB00571Propranolol4Completed1
DB00083Botulinum toxin type ANot AvailableCompleted1
DB00571PropranololNot AvailableActive Not Recruiting1
DB00909ZonisamideNot AvailableTerminated1