Acute Lymphoblastic Leukaemia Recurrent

Also known as: Acute lymphoblastic leukemia recurrent / Recurrent Acute lymphoblastic leukemia / Acute, recurrent Lymphoblastic Leukaemia / Relapsed ALL / Acute, recurrent Lymphoblastic Leukemia / Acute, relapsed Lymphoblastic Leukemia / Relapsed Acute Lymphoblastic Leukemia / Acute lymphocytic leukemia recurrent / Acute lymphocytic leukaemia recurrent

DrugDrug NameDrug Description
DB00631ClofarabineClofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaemia (ALL), only after at least two other types of treatment have failed. It is not known if the drug extends life expectancy. Its potential use in acute myeloid leukaemia (AML) and juvenile myelomonocytic leukaemia (JMML) has been investigated.
DB00444TeniposideA semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle. [PubChem]
DB00541VincristineVincristine is an antitumor vinca alkaloid isolated from Vinca Rosea. It is marketed under several brand names, many of which have different formulations such as Marqibo (liposomal injection) and Vincasar. Vincristine is indicated for the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis. vincristine sulfate is often chosen as part of polychemotherapy because of lack of significant bone–marrow suppression (at recommended doses) and of unique clinical toxicity (neuropathy).
DrugDrug NameTargetType
DB00631ClofarabineDNA polymerase alpha catalytic subunittarget
DB00631ClofarabineRibonucleoside-diphosphate reductase large subunittarget
DB00631ClofarabineDeoxycytidine kinaseenzyme
DB00631ClofarabineDNAtarget
DB00631ClofarabineATP-binding cassette sub-family G member 2transporter
DB00444TeniposideDNA topoisomerase 2-alphatarget
DB00444TeniposideCytochrome P450 2C19enzyme
DB00444TeniposideCytochrome P450 2C9enzyme
DB00444TeniposideCytochrome P450 3A4enzyme
DB00444TeniposideMultidrug resistance-associated protein 6transporter
DB00444TeniposideATP-binding cassette sub-family G member 2transporter
DB00444TeniposideCytochrome P450 3A5enzyme
DB00541VincristineTubulin beta chaintarget
DB00541VincristineCytochrome P450 3A4enzyme
DB00541VincristineCytochrome P450 3A5enzyme
DB00541VincristineCytochrome P450 3A7enzyme
DB00541VincristineMultidrug resistance protein 1transporter
DB00541VincristineCanalicular multispecific organic anion transporter 2transporter
DB00541VincristineSolute carrier family 22 member 3transporter
DB00541VincristineMultidrug resistance-associated protein 1transporter
DB00541VincristineMultidrug resistance-associated protein 7transporter
DB00541VincristineCanalicular multispecific organic anion transporter 1transporter
DB00541VincristineBile salt export pumptransporter
DB00541VincristineATP-binding cassette sub-family G member 2transporter
DB00541VincristineTubulin alpha-4A chaintarget
DB00541VincristineRalA-binding protein 1transporter
DB00541VincristineSolute carrier organic anion transporter family member 1B1transporter
DB00541VincristineSolute carrier organic anion transporter family member 1B3transporter
DrugDrug NamePhaseStatusCount
DB04974AP19031Not Yet Recruiting1
DB09312Antilymphocyte immunoglobulin (horse)1Active Not Recruiting1
DB00098Antithymocyte immunoglobulin (rabbit)1Active Not Recruiting1
DB08886Asparaginase Erwinia chrysanthemi1Terminated1
DB00023Asparaginase Escherichia coli1Terminated1
DB01008Busulfan1Active Not Recruiting1
DB00493Cefotaxime1Recruiting1
DB00631Clofarabine1Active Not Recruiting1
DB06189Clofarabine1Active Not Recruiting1
DB00531Cyclophosphamide1Recruiting1
DB00987Cytarabine1Recruiting2
DB00987Cytarabine1Terminated1
DB01262Decitabine1Recruiting1
DB01234Dexamethasone1Recruiting2
DB01234Dexamethasone1Terminated1
DB14649Dexamethasone acetate1Terminated1
DB00380Dexrazoxane1Terminated1
DB00997Doxorubicin1Recruiting1
DB00997Doxorubicin1Terminated1
DB01073Fludarabine1Active Not Recruiting1
DB01073Fludarabine1Recruiting2
DB00741Hydrocortisone1Recruiting1
DB00480Lenalidomide1Recruiting1
DB01042Melphalan1Recruiting1
DB00563Methotrexate1Recruiting1
DB00563Methotrexate1Terminated1
DB14219Monomethyl fumarate1Recruiting1
DB00688Mycophenolate mofetil1Recruiting1
DB09073Palbociclib1Recruiting1
DB00059Pegaspargase1Recruiting1
DB11759Pevonedistat1Recruiting1
DB00073Rituximab1Recruiting1
DB14797SEphB4-HSA1Recruiting1
DB00398Sorafenib1Recruiting1
DB00864Tacrolimus1Recruiting1
DB00541Vincristine1Recruiting2
DB00541Vincristine1Terminated1
DB02546Vorinostat1Active Not Recruiting1
DB09052Blinatumomab1 / 2Recruiting1
DB00091Ciclosporin1 / 2Recruiting1
DB01234Dexamethasone1 / 2Recruiting2
DB01073Fludarabine1 / 2Recruiting1
DB00688Mycophenolate mofetil1 / 2Recruiting1
DB09037Pembrolizumab1 / 2Recruiting1
DB08901Ponatinib1 / 2Recruiting1
DB00073Rituximab1 / 2Recruiting1
DB11689Selumetinib1 / 2Recruiting1
DB00877Sirolimus1 / 2Recruiting1
DB11581Venetoclax1 / 2Recruiting1
DB09052Blinatumomab2Recruiting1
DB00188Bortezomib2Recruiting1
DB00493Cefotaxime2Active Not Recruiting1
DB00493Cefotaxime2Recruiting3
DB00631Clofarabine2Recruiting1
DB00531Cyclophosphamide2Active Not Recruiting1
DB00531Cyclophosphamide2Recruiting3
DB00987Cytarabine2Active Not Recruiting1
DB00987Cytarabine2Recruiting3
DB01254Dasatinib2Active Not Recruiting1
DB00694Daunorubicin2Recruiting1
DB01234Dexamethasone2Active Not Recruiting1
DB01234Dexamethasone2Recruiting1
DB00997Doxorubicin2Active Not Recruiting1
DB00898Ethanol2Active Not Recruiting1
DB00773Etoposide2Recruiting1
DB00099Filgrastim2Recruiting1
DB01073Fludarabine2Recruiting1
DB05889Inotuzumab ozogamicin2Active Not Recruiting1
DB00563Methotrexate2Active Not Recruiting1
DB00563Methotrexate2Recruiting3
DB00688Mycophenolate mofetil2Recruiting1
DB06650Ofatumumab2Recruiting1
DB00019Pegfilgrastim2Recruiting2
DB09037Pembrolizumab2Recruiting1
DB08901Ponatinib2Recruiting2
DB00635Prednisone2Active Not Recruiting1
DB14646Prednisone acetate2Active Not Recruiting1
DB00073Rituximab2Recruiting2
DB00864Tacrolimus2Recruiting1
DB04572Thiotepa2Recruiting1
DB00541Vincristine2Active Not Recruiting1
DB00541Vincristine2Recruiting2