Ventricular Tachycardia (VT)

Also known as: Ventricular Tachycardias / Tachycardia, Ventricular / Ventricular, Tachycardia / Ventricular Tachycardia / Tachycardias, Ventricular / Tachycardia - ventric. / Tachycardia ventricular / Ventricular tachyarrhythmia / V.tach

DrugDrug NameDrug Description
DB01158BretyliumBretylium blocks the release of noradrenaline from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibrillation. The primary mode of action for bretylium is thought to be inhibition of voltage-gated K(+) channels. Recent evidence has shown that bretylium may also inhibit the Na,K-ATPase by binding to the extracellular K-site.
DB01195FlecainideA potent anti-arrhythmia agent, effective in a wide range of ventricular and atrial arrhythmias and tachycardias. Paradoxically, however, in myocardial infarct patients with either symptomatic or asymptomatic arrhythmia, flecainide exacerbates the arrhythmia and is not recommended for use in these patients.
DB01035ProcainamideA derivative of procaine with less CNS action.
DB00571PropranololA widely used non-cardioselective beta-adrenergic antagonist. Propranolol is used in the treatment or prevention of many disorders including acute myocardial infarction, arrhythmias, angina pectoris, hypertension, hypertensive emergencies, hyperthyroidism, migraine, pheochromocytoma, menopause, and anxiety.
DrugDrug NameTargetType
DB01158BretyliumSodium/potassium-transporting ATPase subunit alpha-1target
DB01195FlecainideSodium channel protein type 5 subunit alphatarget
DB01195FlecainideCytochrome P450 2D6enzyme
DB01195FlecainideSodium channel protein type 4 subunit alphatarget
DB01195FlecainideCytochrome P450 2C9enzyme
DB01195FlecainidePotassium voltage-gated channel subfamily H member 2target
DB01035ProcainamideSodium channel protein type 5 subunit alphatarget
DB01035ProcainamideDNA (cytosine-5)-methyltransferase 1target
DB01035ProcainamideCytochrome P450 2D6enzyme
DB01035ProcainamideCholinesteraseenzyme
DB01035ProcainamideSolute carrier family 22 member 2transporter
DB01035ProcainamideSolute carrier family 22 member 1transporter
DB01035ProcainamideSolute carrier family 22 member 3transporter
DB01035ProcainamideSolute carrier family 22 member 5transporter
DB01035ProcainamideSolute carrier family 22 member 4transporter
DB01035ProcainamidePotassium voltage-gated channel subfamily H member 2target
DB01035ProcainamideMultidrug and toxin extrusion protein 1transporter
DB01035ProcainamideMultidrug and toxin extrusion protein 2transporter
DB00571PropranololBeta-1 adrenergic receptortarget
DB00571PropranololBeta-2 adrenergic receptortarget
DB00571PropranololBeta-3 adrenergic receptortarget
DB00571Propranolol5-hydroxytryptamine receptor 1Atarget
DB00571Propranolol5-hydroxytryptamine receptor 1Btarget
DB00571PropranololCytochrome P450 1A2enzyme
DB00571PropranololCytochrome P450 2D6enzyme
DB00571PropranololAlpha-1-acid glycoprotein 1carrier
DB00571PropranololCytochrome P450 2C19enzyme
DB00571PropranololCytochrome P450 3A4enzyme
DB00571PropranololCytochrome P450 3A5enzyme
DB00571PropranololCytochrome P450 3A7enzyme
DB00571PropranololSolute carrier family 22 member 2transporter
DB00571PropranololMultidrug resistance protein 1transporter
DB00571PropranololCytochrome P450 1A1enzyme
DB00571PropranololAmine oxidase [flavin-containing] Aenzyme
DrugDrug NamePhaseStatusCount
DB13961Fish oil1 / 2Completed1
DB00264Metoprolol2Terminated1
DB00898Ethanol2 / 3Active Not Recruiting1
DB02325Isopropyl alcohol2 / 3Active Not Recruiting1
DB01118Amiodarone3Terminated1
DB00458Imipramine3Completed1
DB00379Mexiletine3Completed1
DB01035Procainamide3Completed1
DB00908Quinidine3Completed1
DB00489Sotalol3Completed2
DB00945Acetylsalicylic acid4Terminated1
DB01426Ajmaline4Completed1
DB06605Apixaban4Terminated1
DB01195Flecainide4Completed1
DB01035Procainamide4Completed1
DB00243Ranolazine4Unknown Status1
DB00899Remifentanil4Completed1
DB01118AmiodaroneNot AvailableTerminated2
DB00575ClonidineNot AvailableWithdrawn1
DB00813FentanylNot AvailableRecruiting1
DB00264MetoprololNot AvailableWithdrawn1
DB00683MidazolamNot AvailableRecruiting1
DB00556PerflutrenNot AvailableActive Not Recruiting1
DB00818PropofolNot AvailableRecruiting1
DB00243RanolazineNot AvailableCompleted1
DB01236SevofluraneNot AvailableRecruiting1
DB00489SotalolNot AvailableTerminated1