Ewing's Sarcoma (ES)

Also known as: Ewing's Sarcoma / Ewing sarcoma / Ewings Sarcoma / Sarcoma, Ewing's / Sarcoma, Ewing / Sarcoma, Ewings / Ewing's sarcoma NOS / Ewing's sarcoma stage unspecified / Ewing's tumor / Ewing's tumour

DrugDrug NameDrug Description
DB00531CyclophosphamidePrecursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer. [PubChem]
DB00970DactinomycinA compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
DB01248DocetaxelDocetaxel is a clinically well established anti-mitotic chemotherapy medication used mainly for the treatment of breast, ovarian, and non-small cell lung cancer. Docetaxel binds to microtubules reversibly with high affinity and has a maximum stoichiometry of one mole docetaxel per mole tubulin in microtubules.
DB00773EtoposideA semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. [PubChem]
DB01181IfosfamideIfosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppresive agent.
DB00762IrinotecanIrinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cell death. It is a derivative of camptothecin. Irinotecan was approved for the treatment of advanced pancreatic cancer in October, 2015 (irinotecan liposome injection, trade name Onivyde).
DB01030TopotecanAn antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. [PubChem]
DrugDrug NameTargetType
DB00531CyclophosphamideCytochrome P450 2B6enzyme
DB00531CyclophosphamideCytochrome P450 2C9enzyme
DB00531CyclophosphamideCytochrome P450 3A4enzyme
DB00531CyclophosphamideCytochrome P450 2C19enzyme
DB00531CyclophosphamideCytochrome P450 2A6enzyme
DB00531CyclophosphamideCytochrome P450 2C18enzyme
DB00531CyclophosphamideCytochrome P450 2C8enzyme
DB00531CyclophosphamideCytochrome P450 2D6enzyme
DB00531CyclophosphamideCytochrome P450 3A7enzyme
DB00531CyclophosphamideCytochrome P450 3A5enzyme
DB00531CyclophosphamideDNAtarget
DB00531CyclophosphamideNuclear receptor subfamily 1 group I member 2target
DB00531CyclophosphamideMultidrug resistance protein 1transporter
DB00970DactinomycinDNAtarget
DB00970DactinomycinSolute carrier family 22 member 5transporter
DB00970DactinomycinMultidrug resistance protein 1transporter
DB00970DactinomycinMultidrug resistance-associated protein 6transporter
DB00970DactinomycinMultidrug resistance-associated protein 1transporter
DB00970DactinomycinATP-binding cassette sub-family G member 2transporter
DB00970DactinomycinDNA topoisomerase 2target
DB01248DocetaxelApoptosis regulator Bcl-2target
DB01248DocetaxelTubulin beta-1 chaintarget
DB01248DocetaxelCytochrome P450 3A4enzyme
DB01248DocetaxelCytochrome P450 3A5enzyme
DB01248DocetaxelCytochrome P450 3A7enzyme
DB01248DocetaxelMultidrug resistance protein 1transporter
DB01248DocetaxelMultidrug resistance-associated protein 7transporter
DB01248DocetaxelCytochrome P450 1B1enzyme
DB01248DocetaxelMicrotubule-associated protein 2target
DB01248DocetaxelMicrotubule-associated protein 4target
DB01248DocetaxelMicrotubule-associated protein tautarget
DB01248DocetaxelSolute carrier organic anion transporter family member 1B3transporter
DB01248DocetaxelSolute carrier family 22 member 7transporter
DB01248DocetaxelATP-binding cassette sub-family G member 2transporter
DB01248DocetaxelCanalicular multispecific organic anion transporter 1transporter
DB01248DocetaxelMultidrug resistance-associated protein 1transporter
DB01248DocetaxelNuclear receptor subfamily 1 group I member 2target
DB00773EtoposideDNA topoisomerase 2-alphatarget
DB00773EtoposideCytochrome P450 3A4enzyme
DB00773EtoposideCanalicular multispecific organic anion transporter 2transporter
DB00773EtoposideMultidrug resistance-associated protein 6transporter
DB00773EtoposideMultidrug resistance protein 1transporter
DB00773EtoposideMultidrug resistance-associated protein 1transporter
DB00773EtoposideMultidrug resistance-associated protein 7transporter
DB00773EtoposideCanalicular multispecific organic anion transporter 1transporter
DB00773EtoposideATP-binding cassette sub-family G member 2transporter
DB00773EtoposideCytochrome P450 1A2enzyme
DB00773EtoposideCytochrome P450 2C8enzyme
DB00773EtoposideCytochrome P450 2E1enzyme
DB00773EtoposideCytochrome P450 3A5enzyme
DB00773EtoposideUDP-glucuronosyltransferase 1-1enzyme
DB00773EtoposideDNA topoisomerase 2-betatarget
DB00773EtoposideGlutathione S-transferase theta-1enzyme
DB00773EtoposideGlutathione S-transferase Penzyme
DB00773EtoposideProstaglandin G/H synthase 2enzyme
DB00773EtoposideProstaglandin G/H synthase 1enzyme
DB01181IfosfamideCytochrome P450 2B6enzyme
DB01181IfosfamideDNAtarget
DB01181IfosfamideCytochrome P450 3A4enzyme
DB01181IfosfamideCytochrome P450 3A5enzyme
DB01181IfosfamideCytochrome P450 2C9enzyme
DB01181IfosfamideCytochrome P450 2C8enzyme
DB01181IfosfamideCytochrome P450 2A6enzyme
DB01181IfosfamideCytochrome P450 2C19enzyme
DB01181IfosfamideCytochrome P450 2C18enzyme
DB01181IfosfamideProstaglandin G/H synthase 1enzyme
DB01181IfosfamideCytochrome P450 3A7enzyme
DB01181IfosfamideNuclear receptor subfamily 1 group I member 2target
DB00762IrinotecanDNA topoisomerase I, mitochondrialtarget
DB00762IrinotecanDNA topoisomerase 1target
DB00762IrinotecanCytochrome P450 3A4enzyme
DB00762IrinotecanCytochrome P450 3A5enzyme
DB00762IrinotecanUDP-glucuronosyltransferase 1-1enzyme
DB00762IrinotecanUDP-glucuronosyltransferase 1-9enzyme
DB00762IrinotecanLiver carboxylesterase 1enzyme
DB00762IrinotecanCytochrome P450 3A7enzyme
DB00762IrinotecanCytochrome P450 2B6enzyme
DB00762IrinotecanSolute carrier family 22 member 3transporter
DB00762IrinotecanSolute carrier organic anion transporter family member 1B1transporter
DB00762IrinotecanMultidrug resistance-associated protein 1transporter
DB00762IrinotecanATP-binding cassette sub-family G member 2transporter
DB00762IrinotecanSerum albumincarrier
DB00762IrinotecanCocaine esteraseenzyme
DB00762IrinotecanCholinesteraseenzyme
DB00762IrinotecanMultidrug resistance protein 1transporter
DB00762IrinotecanCanalicular multispecific organic anion transporter 1transporter
DB01030TopotecanDNA topoisomerase I, mitochondrialtarget
DB01030TopotecanDNA topoisomerase 1target
DB01030TopotecanATP-binding cassette sub-family G member 2transporter
DB01030TopotecanMultidrug resistance protein 1transporter
DB01030TopotecanCytochrome P450 3A4enzyme
DB01030TopotecanDNAtarget
DrugDrug NamePhaseStatusCount
DB00531Cyclophosphamide0Recruiting1
DB01041Thalidomide0Recruiting1
DB00087Alemtuzumab1Recruiting1
DB00098Antithymocyte immunoglobulin (rabbit)1Completed1
DB01008Busulfan1Completed1
DB01008Busulfan1Recruiting1
DB01008Busulfan1Withdrawn1
DB00531Cyclophosphamide1Completed1
DB00531Cyclophosphamide1Recruiting2
DB00997Doxorubicin1Completed1
DB00997Doxorubicin1Recruiting1
DB05847Doxorubicin1Recruiting1
DB11685Figitumumab1Completed1
DB00099Filgrastim1Completed1
DB01073Fludarabine1Completed1
DB01073Fludarabine1Recruiting1
DB00762Irinotecan1Recruiting2
DB00125L-Arginine1Recruiting1
DB01042Melphalan1Completed1
DB01042Melphalan1Recruiting1
DB01042Melphalan1Withdrawn1
DB00745Modafinil1Active Not Recruiting1
DB11793Niraparib1Recruiting1
DB09074Olaparib1Recruiting1
DB13045Racotumomab1Completed1
DB00641Simvastatin1Recruiting1
DB00877Sirolimus1Active Not Recruiting1
DB00877Sirolimus1Recruiting1
DB11760Talazoparib1Completed1
DB00853Temozolomide1Recruiting2
DB01030Topotecan1Recruiting1
DB00541Vincristine1Completed1
DB00399Zoledronic acid1Recruiting1
DB00041Aldesleukin1 / 2Active Not Recruiting1
DB09035Nivolumab1 / 2Not Yet Recruiting1
DB01229Paclitaxel1 / 2Active Not Recruiting1
DB06810Plicamycin1 / 2Terminated1
DB00853Temozolomide1 / 2Completed1
DB12182Binetrakin2Completed1
DB01008Busulfan2Recruiting1
DB08875Cabozantinib2Recruiting1
DB00958Carboplatin2Completed1
DB00515Cisplatin2Completed1
DB09110Coenzyme M2Completed1
DB09110Coenzyme M2Terminated1
DB00531Cyclophosphamide2Completed1
DB00531Cyclophosphamide2Recruiting1
DB00531Cyclophosphamide2Terminated2
DB01254Dasatinib2Active Not Recruiting1
DB00380Dexrazoxane2Completed1
DB00380Dexrazoxane2Terminated1
DB00997Doxorubicin2Completed1
DB00997Doxorubicin2Recruiting1
DB00997Doxorubicin2Terminated2
DB00530Erlotinib2Recruiting1
DB00773Etoposide2Completed1
DB00773Etoposide2Recruiting1
DB00441Gemcitabine2Recruiting1
DB01645Genistein2Recruiting1
DB01181Ifosfamide2Completed1
DB01181Ifosfamide2Recruiting1
DB00224Indinavir2Completed1
DB00762Irinotecan2Active Not Recruiting1
DB00762Irinotecan2Recruiting1
DB00762Irinotecan2Terminated1
DB00134L-Methionine2Recruiting1
DB01042Melphalan2Completed1
DB01042Melphalan2Recruiting1
DB00745Modafinil2Active Not Recruiting1
DB09074Olaparib2Completed1
DB01229Paclitaxel2Recruiting2
DB00019Pegfilgrastim2Completed1
DB00019Pegfilgrastim2Terminated1
DB00642Pemetrexed2Completed1
DB12976Robatumumab2Terminated1
DB00020Sargramostim2Completed1
DB00853Temozolomide2Active Not Recruiting1
DB00853Temozolomide2Recruiting2
DB00853Temozolomide2Terminated1
DB01030Topotecan2Completed1
DB08881Vemurafenib2Recruiting1
DB00541Vincristine2Completed1
DB00541Vincristine2Recruiting1
DB00541Vincristine2Terminated2
DB12454Zalypsis2Completed1
DB01008Busulfan3Recruiting2
DB00531Cyclophosphamide3Recruiting1
DB00970Dactinomycin3Recruiting1
DB00997Doxorubicin3Recruiting1
DB00773Etoposide3Recruiting1
DB01181Ifosfamide3Recruiting1
DB01042Melphalan3Recruiting1
DB11678Treosulfan3Recruiting1
DB00541Vincristine3Recruiting1
DB00399Zoledronic acid3Recruiting1
DB01008BusulfanNot AvailableActive Not Recruiting1
DB06215FerumoxytolNot AvailableRecruiting1
DB00099FilgrastimNot AvailableActive Not Recruiting1
DB12205GanitumabNot AvailableAvailable1
DB01181IfosfamideNot AvailableUnknown Status1
DB01042MelphalanNot AvailableActive Not Recruiting1
DB01030TopotecanNot AvailableActive Not Recruiting1
DB00541VincristineNot AvailableUnknown Status1