Homologous Recombination Deficiency

Also known as: Homologous Recombination Deficiency (HRD) / HRD

Drug	Drug Name	Drug Description
DB09074	Olaparib	A poly (ADP-ribose) polymerase (PARP) inhibitor used to treat ovarian cancer, breast cancer, pancreatic cancer, and prostate cancer.

Drug	Drug Name	Target	Type
DB09074	Olaparib	Poly [ADP-ribose] polymerase 1	target
DB09074	Olaparib	Cytochrome P450 3A4	enzyme
DB09074	Olaparib	Cytochrome P450 2B6	enzyme
DB09074	Olaparib	Poly [ADP-ribose] polymerase 2	target
DB09074	Olaparib	Poly [ADP-ribose] polymerase 3	target
DB09074	Olaparib	Cytochrome P450 3A5	enzyme
DB09074	Olaparib	P-glycoprotein 1	transporter
DB09074	Olaparib	ATP-binding cassette sub-family G member 2	transporter
DB09074	Olaparib	Aldo-keto reductase family 1 member C3	target
DB09074	Olaparib	UDP-glucuronosyltransferase 1-1	enzyme
DB09074	Olaparib	Serum albumin	carrier
DB09074	Olaparib	Alpha-1-acid glycoprotein 1	carrier

Drug	Drug Name	Phase	Status	Count
DB00958	Carboplatin	1	Terminated	1
DB11793	Niraparib	1	Terminated	1
DB00112	Bevacizumab	2	Unknown Status	1
DB00958	Carboplatin	2	Active Not Recruiting	1
DB00958	Carboplatin	2	Recruiting	1
DB01248	Docetaxel	2	Active Not Recruiting	1
DB15627	Dostarlimab	2	Withdrawn	1
DB11717	Epacadostat	2	Withdrawn	1
DB11793	Niraparib	2	Not Yet Recruiting	1
DB11793	Niraparib	2	Unknown Status	1
DB11793	Niraparib	2	Withdrawn	1
DB09074	Olaparib	2	Recruiting	3
DB14769	Pamiparib	2	Terminated	1
DB09037	Pembrolizumab	2	Recruiting	1
DB09037	Pembrolizumab	2	Withdrawn	1
DB12332	Rucaparib	2	Active Not Recruiting	1
DB13944	Testosterone enanthate	2	Recruiting	1
DB00515	Cisplatin	2 / 3	Recruiting	1
DB11793	Niraparib	Not Available	Not Yet Recruiting	1
DB09074	Olaparib	Not Available	Not Yet Recruiting	1