EZH2 Gene Mutation

Drug	Drug Name	Drug Description
DB12887	Tazemetostat	A methyltransferase inhibitor indicated to treat patients 16 years and older with metastatic or locally advanced epithelioid sarcoma not eligible for complete resection.

Drug	Drug Name	Target	Type
DB12887	Tazemetostat	Histone-lysine N-methyltransferase EZH2	target
DB12887	Tazemetostat	P-glycoprotein 1	transporter
DB12887	Tazemetostat	Multidrug and toxin extrusion protein 1	transporter
DB12887	Tazemetostat	Multidrug and toxin extrusion protein 2	transporter
DB12887	Tazemetostat	Cytochrome P450 3A Subfamily	enzyme
DB12887	Tazemetostat	Histone-lysine N-methyltransferase EZH1	target
DB12887	Tazemetostat	ATP-binding cassette sub-family G member 2	transporter
DB12887	Tazemetostat	Cytochrome P450 3A4	enzyme

Drug	Drug Name	Phase	Status	Count
DB01008	Busulfan	2	Terminated	1
DB00531	Cyclophosphamide	2	Terminated	1
DB01073	Fludarabine	2	Terminated	1