Leukemia, Acute

Also known as: Acute Leukaemia / Leukemia acute / Acute Leukemia / Leukaemia, Acute / Acute Leukemias / Leukemia of unspecified cell type, acute / Acute leukaemia of unspecified cell type / Acute leukemia of unspecified cell type / Acute bilineal leukemia / Acute leukemia NOS / Leukaemia of unspecified cell type, acute / Leukaemia acute / Acute leukaemia NOS

DrugDrug NameDrug Description
DB00276AmsacrineAminoacridine derivative that is a potent intercalating antineoplastic agent. It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. It is frequently used in combination with other antineoplastic agents in chemotherapy protocols. It produces consistent but acceptable myelosuppression and cardiotoxic effects.
DB01380Cortisone acetateCortisone acetate is a steroid hormone that has both glucocoriticoid and mineral corticoid activities. Corticosteroids are used to provide relief for inflamed areas of the body. They lessen swelling, redness, itching, and allergic reactions. They are often used as part of the treatment for a number of different diseases, such as severe allergies or skin problems, asthma, or arthritis. Endogenous glucocorticoids and some synthetic corticoids have high affinity to the protein transcortin (also called CBG, corticosteroid-binding protein), whereas all of them bind albumin. Glucocorticoids also bind to the cytosolic glucocorticoid receptor.
DB01234DexamethasoneAn anti-inflammatory 9-fluoro-glucocorticoid.
DB00741HydrocortisoneThe main glucocorticoid secreted by the adrenal cortex. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
DB00959MethylprednisoloneA prednisolone derivative with similar anti-inflammatory action.
DB00860PrednisoloneA glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
DB00635PrednisoneA synthetic anti-inflammatory glucocorticoid derived from cortisone. It is biologically inert and converted to prednisolone in the liver.
DrugDrug NameTargetType
DB00276AmsacrineDNA topoisomerase 2-alphatarget
DB00276AmsacrineDNAtarget
DB00276AmsacrinePotassium voltage-gated channel subfamily H member 2target
DB00276AmsacrineMultidrug resistance protein 1transporter
DB00276AmsacrineAlpha-1-acid glycoprotein 1target
DB00276AmsacrineSerum albumintarget
DB01380Cortisone acetateGlucocorticoid receptortarget
DB01380Cortisone acetateCytochrome P450 3A4enzyme
DB01234DexamethasoneGlucocorticoid receptortarget
DB01234DexamethasoneAnnexin A1target
DB01234DexamethasoneNitric oxide synthase, inducibletarget
DB01234DexamethasoneNuclear receptor subfamily 0 group B member 1target
DB01234DexamethasoneCytochrome P450 3A4enzyme
DB01234DexamethasoneCytochrome P450 3A5enzyme
DB01234DexamethasoneCytochrome P450 3A7enzyme
DB01234DexamethasoneBile salt export pumptransporter
DB01234DexamethasoneMultidrug resistance protein 1transporter
DB01234DexamethasoneCanalicular multispecific organic anion transporter 1transporter
DB01234DexamethasoneSolute carrier organic anion transporter family member 1A2transporter
DB01234DexamethasoneATP-binding cassette sub-family G member 2transporter
DB01234DexamethasoneCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DB01234DexamethasoneSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
DB01234DexamethasoneCytochrome P450 19A1enzyme
DB01234DexamethasoneCytochrome P450 1A1enzyme
DB01234DexamethasoneCytochrome P450 1B1enzyme
DB01234DexamethasoneCytochrome P450 2A6enzyme
DB01234DexamethasoneCytochrome P450 2B6enzyme
DB01234DexamethasoneCytochrome P450 2C19enzyme
DB01234DexamethasoneCytochrome P450 2C8enzyme
DB01234DexamethasoneCytochrome P450 2D6enzyme
DB01234DexamethasoneCytochrome P450 2E1enzyme
DB01234DexamethasoneCytochrome P450 3A43enzyme
DB01234DexamethasoneCytochrome P450 4A11enzyme
DB01234DexamethasoneNuclear receptor subfamily 1 group I member 2target
DB00741HydrocortisoneAnnexin A1target
DB00741HydrocortisoneGlucocorticoid receptortarget
DB00741HydrocortisoneSex hormone-binding globulincarrier
DB00741HydrocortisoneCytochrome P450 3A4enzyme
DB00741HydrocortisoneCytochrome P450 3A5enzyme
DB00741HydrocortisoneCytochrome P450 3A7enzyme
DB00741HydrocortisoneMultidrug resistance protein 1transporter
DB00741HydrocortisoneSolute carrier organic anion transporter family member 1A2transporter
DB00741HydrocortisoneATP-binding cassette sub-family G member 2transporter
DB00741HydrocortisoneCytochrome P450 11B1, mitochondrialenzyme
DB00741HydrocortisoneCytochrome P450 11B2, mitochondrialenzyme
DB00741HydrocortisoneCytochrome P450 2C8enzyme
DB00741HydrocortisoneCorticosteroid-binding globulincarrier
DB00741HydrocortisoneCorticosteroid 11-beta-dehydrogenase isozyme 2target
DB00741Hydrocortisone3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
DB00741HydrocortisoneSolute carrier family 22 member 8transporter
DB00959MethylprednisoloneGlucocorticoid receptortarget
DB00959MethylprednisoloneCytochrome P450 3A4enzyme
DB00959MethylprednisoloneMultidrug resistance protein 1transporter
DB00860PrednisoloneCorticosteroid-binding globulincarrier
DB00860PrednisoloneCytochrome P450 3A4enzyme
DB00860PrednisoloneGlucocorticoid receptortarget
DB00860PrednisoloneSolute carrier organic anion transporter family member 1A2transporter
DB00860PrednisoloneMultidrug resistance protein 1transporter
DB00635PrednisoneGlucocorticoid receptortarget
DB00635PrednisoneCytochrome P450 3A4enzyme
DB00635PrednisoneMultidrug resistance protein 1transporter
DB00635PrednisoneSolute carrier organic anion transporter family member 1A2transporter
DB00635PrednisoneCytochrome P450 2C19enzyme
DB00635PrednisoneSerum albumincarrier
DB00635PrednisoneCorticosteroid 11-beta-dehydrogenase isozyme 1target
DrugDrug NamePhaseStatusCount
DB06769Bendamustine1Completed1
DB01008Busulfan1Recruiting1
DB00631Clofarabine1Completed1
DB06189Clofarabine1Completed1
DB00631Clofarabine1Terminated1
DB09110Coenzyme M1Recruiting1
DB00531Cyclophosphamide1Recruiting1
DB00531Cyclophosphamide1Terminated1
DB00987Cytarabine1Recruiting1
DB06179Darinaparsin1Completed1
DB01234Dexamethasone1Completed1
DB00997Doxorubicin1Recruiting1
DB00773Etoposide1Completed1
DB01073Fludarabine1Recruiting1
DB00741Hydrocortisone1Recruiting1
DB00762Irinotecan1Unknown Status1
DB00125L-Arginine1Completed1
DB00480Lenalidomide1Terminated1
DB11861Litronesib1Terminated1
DB01042Melphalan1Recruiting1
DB00563Methotrexate1Recruiting1
DB09035Nivolumab1Recruiting1
DB09073Palbociclib1Recruiting1
DB00059Pegaspargase1Recruiting1
DB12920Pinometostat1Completed1
DB00860Prednisolone1Recruiting1
DB06273Tocilizumab1Recruiting1
DB00541Vincristine1Recruiting1
DB00087Alemtuzumab1 / 2Completed1
DB00098Antithymocyte immunoglobulin (rabbit)1 / 2Terminated1
DB00091Ciclosporin1 / 2Completed1
DB00531Cyclophosphamide1 / 2Unknown Status1
DB00987Cytarabine1 / 2Recruiting1
DB00099Filgrastim1 / 2Unknown Status1
DB01073Fludarabine1 / 2Terminated1
DB01073Fludarabine1 / 2Unknown Status1
DB01042Melphalan1 / 2Terminated2
DB00688Mycophenolate mofetil1 / 2Unknown Status1
DB00039Palifermin1 / 2Recruiting1
DB00073Rituximab1 / 2Completed1
DB00073Rituximab1 / 2Recruiting1
DB00073Rituximab1 / 2Unknown Status1
DB00864Tacrolimus1 / 2Completed1
DB00864Tacrolimus1 / 2Unknown Status1
DB04572Thiotepa1 / 2Terminated2
DB11471Tilmicosin1 / 2Completed1
DB11471Tilmicosin1 / 2Recruiting1
DB09312Antilymphocyte immunoglobulin (horse)2Terminated1
DB00098Antithymocyte immunoglobulin (rabbit)2Terminated1
DB00188Bortezomib2Completed1
DB00188Bortezomib2Terminated1
DB01008Busulfan2Completed1
DB01008Busulfan2Not Yet Recruiting1
DB01008Busulfan2Recruiting3
DB00493Cefotaxime2Recruiting1
DB00091Ciclosporin2Completed1
DB00091Ciclosporin2Not Yet Recruiting1
DB00091Ciclosporin2Recruiting1
DB00531Cyclophosphamide2Completed1
DB00531Cyclophosphamide2Not Yet Recruiting2
DB00531Cyclophosphamide2Recruiting3
DB00987Cytarabine2Completed1
DB00987Cytarabine2Recruiting1
DB00694Daunorubicin2Completed1
DB06210Eltrombopag2Completed1
DB00099Filgrastim2Recruiting1
DB01073Fludarabine2Completed1
DB01073Fludarabine2Not Yet Recruiting1
DB01073Fludarabine2Recruiting3
DB01073Fludarabine2Unknown Status1
DB09570Ixazomib2Active Not Recruiting1
DB04835Maraviroc2Completed1
DB01042Melphalan2Recruiting1
DB00563Methotrexate2Completed1
DB00563Methotrexate2Not Yet Recruiting1
DB01141Micafungin2Completed1
DB00688Mycophenolate mofetil2Completed2
DB00688Mycophenolate mofetil2Recruiting3
DB00039Palifermin2Withdrawn1
DB00811Ribavirin2Active Not Recruiting1
DB13647Semustine2Recruiting1
DB00877Sirolimus2Recruiting1
DB09143Sonidegib2Completed1
DB00864Tacrolimus2Completed1
DB00864Tacrolimus2Not Yet Recruiting1
DB00864Tacrolimus2Recruiting1
DB00864Tacrolimus2Terminated1
DB04572Thiotepa2Not Yet Recruiting1
DB06273Tocilizumab2Recruiting1
DB06334Tucidinostat2Not Yet Recruiting1
DB00493Cefotaxime2 / 3Recruiting2
DB00631Clofarabine2 / 3Completed1
DB00531Cyclophosphamide2 / 3Completed1
DB00531Cyclophosphamide2 / 3Recruiting2
DB00987Cytarabine2 / 3Recruiting2
DB01254Dasatinib2 / 3Recruiting1
DB01234Dexamethasone2 / 3Recruiting2
DB00997Doxorubicin2 / 3Recruiting2
DB00773Etoposide2 / 3Completed1
DB00773Etoposide2 / 3Recruiting2
DB01177Idarubicin2 / 3Recruiting2
DB01033Mercaptopurine2 / 3Recruiting2
DB00563Methotrexate2 / 3Recruiting2
DB00059Pegaspargase2 / 3Recruiting2
DB06334Tucidinostat2 / 3Recruiting3
DB00541Vincristine2 / 3Recruiting2
DB00531Cyclophosphamide3Active Not Recruiting1
DB00563Methotrexate3Active Not Recruiting1
DB00864Tacrolimus3Active Not Recruiting1
DB01008Busulfan4Not Yet Recruiting1
DB00531Cyclophosphamide4Not Yet Recruiting1
DB00098Antithymocyte immunoglobulin (rabbit)Not AvailableCompleted1
DB01008BusulfanNot AvailableCompleted1
DB00091CiclosporinNot AvailableRecruiting1
DB00531CyclophosphamideNot AvailableActive Not Recruiting1
DB01073FludarabineNot AvailableActive Not Recruiting1
DB01073FludarabineNot AvailableCompleted1
DB01073FludarabineNot AvailableTerminated1
DB01042MelphalanNot AvailableCompleted1
DB01042MelphalanNot AvailableTerminated1
DB00563MethotrexateNot AvailableRecruiting1
DB00688Mycophenolate mofetilNot AvailableRecruiting1
DB04572ThiotepaNot AvailableTerminated1