Pharmacogenomic Effect/ADR for Clomipramine (DBSNPE000004)

Identifier
DBSNPE000004, DBSNPE005557
Drug
Clomipramine (DB01242)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
A Allelers3892097
Allele Name
CYP2D6*4
Genotype(s)
(A;A)
Type(s)
Effect Directly Studied
Groups
Non-functional CYP2D6
Description
Patients with this genotype have reduced metabolism of clomipramine.
References
  1. Bijl MJ, Visser LE, Hofman A, Vulto AG, van Gelder T, Stricker BH, van Schaik RH: Influence of the CYP2D6*4 polymorphism on dose, switching and discontinuation of antidepressants. Br J Clin Pharmacol. 2008 Apr;65(4):558-64. Epub 2007 Dec 7. [PubMed:18070221]