Pharmacogenomic Effect/ADR for Clopidogrel (DBSNPE000005)

Identifier
DBSNPE000005, DBSNPE005592
Drug
Clopidogrel (DB00758)
Interacting Gene/Enzyme
Cytochrome P450 2C9
Gene Name
CYP2C9
UniProt ID
P11712
Defining Change(s)
C Allelers1057910
Allele Name
CYP2C9*3
Genotype(s)
(A;C) / (C;C)
Type(s)
Effect Directly Studied
Groups
Non-functional CYP2C9; Decreased CYP2C9
Description
Patients with this genotype have reduced metabolism of clopidogrel resulting in reduced plasma concentrations of its active metabolite.
References
  1. Brandt JT, Close SL, Iturria SJ, Payne CD, Farid NA, Ernest CS 2nd, Lachno DR, Salazar D, Winters KJ: Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel. J Thromb Haemost. 2007 Dec;5(12):2429-36. Epub 2007 Sep 26. [PubMed:17900275]