Pharmacogenomic Effect/ADR for Codeine (DBSNPE000008)

Identifier
DBSNPE000008, DBSNPE005619
Drug
Codeine (DB00318)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
T deletion, homozygoters5030655
Allele Name
CYP2D6*6
Genotype(s)
(-;-)
Type(s)
Effect Directly Studied
Groups
Non-functional CYP2D6
Description
Patients with this genotype have reduced metabolism of codeine.
References
  1. Desmeules J, Gascon MP, Dayer P, Magistris M: Impact of environmental and genetic factors on codeine analgesia. Eur J Clin Pharmacol. 1991;41(1):23-6. [PubMed:1782973]