Pharmacogenomic Effect/ADR for Omeprazole (DBSNPE000022)

Identifier
DBSNPE000022, DBSNPE005822
Drug
Omeprazole (DB00338)
Interacting Gene/Enzyme
Cytochrome P450 2C19
Gene Name
CYP2C19
UniProt ID
P33261
Defining Change(s)
A Allele, homozygoters4986893
Allele Name
CYP2C19*3
Genotype(s)
(A;A)
Type(s)
Effect Directly Studied
Groups
Non-functional CYP2C19
Description
Patients with this genotype have reduced metabolism of omeprazole.
References
  1. Furuta T, Ohashi K, Kamata T, Takashima M, Kosuge K, Kawasaki T, Hanai H, Kubota T, Ishizaki T, Kaneko E: Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcer. Ann Intern Med. 1998 Dec 15;129(12):1027-30. [PubMed:9867757]