Pharmacogenomic Effect/ADR for Phenytoin (DBSNPE000023)

Identifier
DBSNPE000023, DBSNPE005835
Drug
Phenytoin (DB00252)
Interacting Gene/Enzyme
Cytochrome P450 2C9
Gene Name
CYP2C9
UniProt ID
P11712
Defining Change(s)
C Allelers1057910
Allele Name
CYP2C9*3
Genotype(s)
(A;C) / (C;C)
Type(s)
Effect Directly Studied
Groups
Non-functional CYP2C9; Decreased CYP2C9
Description
Patients with this genotype have reduced metabolism of phenytoin.
References
  1. Tate SK, Depondt C, Sisodiya SM, Cavalleri GL, Schorge S, Soranzo N, Thom M, Sen A, Shorvon SD, Sander JW, Wood NW, Goldstein DB: Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin. Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5507-12. Epub 2005 Apr 1. [PubMed:15805193]