Pharmacogenomic Effect/ADR for Sildenafil (DBSNPE000028)

Identifier
DBSNPE000028, DBSNPE000029, DBSNPE000030, DBSNPE000031
Drug
Sildenafil (DB00203)
Interacting Gene/Enzyme
Angiotensin-converting enzyme
Gene Name
ACE
UniProt ID
P12821
Defining Change(s)
Alu insertionsrs1799752
Alu insertionsrs4340
Alu insertionsrs13447447
Alu insertionsrs4646994
Allele Name
Not Available
Genotype(s)
Not Available
Type(s)
Effect Directly Studied
Groups
Not Available
Description
Patients with this genotype have increased frequency of positive erectile response when using sildenafil to treat erectile dysfunction
References
  1. Eisenhardt A, Sperling H, Hauck E, Porst H, Stief C, Rubben H, Muller N, Siffert W: ACE gene I/D and NOS3 G894T polymorphisms and response to sildenafil in men with erectile dysfunction. Urology. 2003 Jul;62(1):152-7. [PubMed:12837457]