Pharmacogenomic Effect/ADR for Venlafaxine (DBSNPE000035)

Identifier
DBSNPE000035, DBSNPE000036, DBSNPE005912
Drug
Venlafaxine (DB00285)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
T deletionrs5030655
T deletion, homozygoters5030655
Allele Name
CYP2D6*6
Genotype(s)
(-;-) / (-;T)
Type(s)
Effect Directly Studied
Groups
Non-functional CYP2D6
Description
Patients with this genotype have reduced metabolism of venlafaxine.
References
  1. Shams ME, Arneth B, Hiemke C, Dragicevic A, Muller MJ, Kaiser R, Lackner K, Hartter S: CYP2D6 polymorphism and clinical effect of the antidepressant venlafaxine. J Clin Pharm Ther. 2006 Oct;31(5):493-502. [PubMed:16958828]