Pharmacogenomic Effect/ADR for Azathioprine (DBSNPE000044)

Identifier
DBSNPE000044
Drug
Azathioprine (DB00993)
Interacting Gene/Enzyme
Thiopurine S-methyltransferase
Gene Name
TPMT
UniProt ID
P51580
Defining Change(s)
G Allelers1142345
Allele Name
TPMT*3C
Genotype(s)
(A;G) / (G;G)
Type(s)
ADR Directly Studied
Groups
Non-functional TPMT
Description
Patients with this genotype have reduced metabolism of azathioprine resulting in increased toxicity.
References
  1. Bosch TM, Meijerman I, Beijnen JH, Schellens JH: Genetic polymorphisms of drug-metabolising enzymes and drug transporters in the chemotherapeutic treatment of cancer. Clin Pharmacokinet. 2006;45(3):253-85. [PubMed:16509759]