Pharmacogenomic Effect/ADR for Irinotecan (DBSNPE000048)

Identifier
DBSNPE000048, DBSNPE000049
Drug
Irinotecan (DB00762)
Interacting Gene/Enzyme
Solute carrier organic anion transporter family member 1B1
Gene Name
SLCO1B1
UniProt ID
Q9Y6L6
Defining Change(s)
C Allelers4149056
G Allelers2306283
Allele Name
SLCO1B1*15
Genotype(s)
(C;C) / (C;T)
Type(s)
Directly Studied Effect
Groups
Not Available
Description
Patients with this genotype have reduced transport of the active metabolite of irinotecan resulting in increased plasma concentrations.
References
  1. Takane H, Miyata M, Burioka N, Kurai J, Fukuoka Y, Suyama H, Shigeoka Y, Otsubo K, Ieiri I, Shimizu E: Severe toxicities after irinotecan-based chemotherapy in a patient with lung cancer: a homozygote for the SLCO1B1*15 allele. Ther Drug Monit. 2007 Oct;29(5):666-8. [PubMed:17898662]