Pharmacogenomic Effect/ADR for Irinotecan (DBSNPE000050)

Identifier
DBSNPE000050
Drug
Irinotecan (DB00762)
Interacting Gene/Enzyme
UDP-glucuronosyltransferase 1-1
Gene Name
UGT1A1
UniProt ID
P22309
Defining Change(s)
extra TA in promoterrs8175347
Allele Name
UGT1A1*28 or UGT1A 7/7
Genotype(s)
Not Available
Type(s)
ADR Directly Studied
Groups
Not Available
Description
The presence of this genotype in UGT1A1 may indicate an increased risk of bone marrow toxicity when treated with irinotecan.
References
  1. Fakih MG, Ross ME, Starostik P: Increased frequency of uridine diphosphate glucuronosyltransferase 1A1 7/7 in patients experiencing severe irinotecan-induced toxicities. Clin Colorectal Cancer. 2007 Jul;6(8):583-7. [PubMed:17681105]