Pharmacogenomic Effect/ADR for Irinotecan (DBSNPE000051)

Identifier
DBSNPE000051, DBSNPE000052, DBSNPE000053
Drug
Irinotecan (DB00762)
Interacting Gene/Enzyme
UDP-glucuronosyltransferase 1-7
Gene Name
UGT1A7
UniProt ID
Q9HAW7
Defining Change(s)
G allelers17868323
A allelers17863778
A allelers17868324
Allele Name
UGT1A7*2/*2
Genotype(s)
(A;A) / (A;C) / (A;G) / (G;G) / (G;T)
Type(s)
ADR Directly Studied
Groups
Not Available
Description
The presence of this genotype in UGT1A1 may indicate an increased risk of bone marrow toxicity when treated with irinotecan.
References
  1. Lankisch TO, Schulz C, Zwingers T, Erichsen TJ, Manns MP, Heinemann V, Strassburg CP: Gilbert's Syndrome and irinotecan toxicity: combination with UDP-glucuronosyltransferase 1A7 variants increases risk. Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):695-701. doi: 10.1158/1055-9965.EPI-07-2517. [PubMed:18349289]