Pharmacogenomic Effect/ADR for Mercaptopurine (DBSNPE000056)

Identifier
DBSNPE000056
Drug
Mercaptopurine (DB01033)
Interacting Gene/Enzyme
Thiopurine S-methyltransferase
Gene Name
TPMT
UniProt ID
P51580
Defining Change(s)
A Allelers1800460
Allele Name
TPMT*3A
Genotype(s)
(A;A) / (A;G)
Type(s)
ADR Directly Studied
Groups
Non-functional TPMT
Description
Patients with this genotype have reduced metabolism of mercaptopurine resulting in increased toxicity.
References
  1. Bosch TM, Meijerman I, Beijnen JH, Schellens JH: Genetic polymorphisms of drug-metabolising enzymes and drug transporters in the chemotherapeutic treatment of cancer. Clin Pharmacokinet. 2006;45(3):253-85. [PubMed:16509759]