Pharmacogenomic Effect/ADR for Almotriptan (DBSNPE000063)

Identifier
DBSNPE000063
Drug
Almotriptan (DB00918)
Interacting Gene/Enzyme
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
Gene Name
GNB3
UniProt ID
P16520
Defining Change(s)
T Allelers5443
Allele Name
Not Available
Genotype(s)
(C;T) / (T;T)
Type(s)
Effect Directly Studied
Groups
Not Available
Description
Patients with this genotype have an increased likelihood of responding to almotriptan when treating cluster headache.
References
  1. Schurks M, Kurth T, Stude P, Rimmbach C, de Jesus J, Jonjic M, Diener HC, Rosskopf D: G protein beta3 polymorphism and triptan response in cluster headache. Clin Pharmacol Ther. 2007 Oct;82(4):396-401. Epub 2007 Mar 14. [PubMed:17361120]