Pharmacogenomic Effect/ADR for Bleomycin (DBSNPE000068)

Identifier
DBSNPE000068
Drug
Bleomycin (DB00290)
Interacting Gene/Enzyme
Bleomycin hydrolase
Gene Name
BLMH
UniProt ID
Q13867
Defining Change(s)
G Allelers10500565
Allele Name
Not Available
Genotype(s)
(G;G)
Type(s)
Effect Directly Studied
Groups
Not Available
Description
Patients with this genotype have reduced survival time and increased frequency of early relapse when using bleomycin to treat testicular cancer.
References
  1. de Haas EC, Zwart N, Meijer C, Nuver J, Boezen HM, Suurmeijer AJ, Hoekstra HJ, van der Steege G, Sleijfer DT, Gietema JA: Variation in bleomycin hydrolase gene is associated with reduced survival after chemotherapy for testicular germ cell cancer. J Clin Oncol. 2008 Apr 10;26(11):1817-23. doi: 10.1200/JCO.2007.14.1606. [PubMed:18398146]