Pharmacogenomic Effect/ADR for Metoprolol (DBSNPE000077)

Identifier
DBSNPE000077
Drug
Metoprolol (DB00264)
Interacting Gene/Enzyme
Beta-1 adrenergic receptor
Gene Name
ADRB1
UniProt ID
P08588
Defining Change(s)
A Allelers1801252
Allele Name
Not Available
Genotype(s)
(A;A)
Type(s)
Effect Directly Studied
Groups
Not Available
Description
Patients with this genotype have a greater reduction in blood pressure with metoprolol.
References
  1. Johnson JA, Zineh I, Puckett BJ, McGorray SP, Yarandi HN, Pauly DF: Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol. Clin Pharmacol Ther. 2003 Jul;74(1):44-52. [PubMed:12844134]