Pharmacogenomic Effect/ADR for Naratriptan (DBSNPE000080)

Identifier
DBSNPE000080
Drug
Naratriptan (DB00952)
Interacting Gene/Enzyme
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
Gene Name
GNB3
UniProt ID
P16520
Defining Change(s)
T Allelers5443
Allele Name
Not Available
Genotype(s)
(C;T) / (T;T)
Type(s)
Effect Directly Studied
Groups
Not Available
Description
Patients with this genotype have an increased likelihood of responding to naratriptan when treating (condition: cluster headache).
References
  1. Schurks M, Kurth T, Stude P, Rimmbach C, de Jesus J, Jonjic M, Diener HC, Rosskopf D: G protein beta3 polymorphism and triptan response in cluster headache. Clin Pharmacol Ther. 2007 Oct;82(4):396-401. Epub 2007 Mar 14. [PubMed:17361120]