Pharmacogenomic Effect/ADR for Pravastatin (DBSNPE000082)

Identifier
DBSNPE000082
Drug
Pravastatin (DB00175)
Interacting Gene/Enzyme
Kinesin-like protein KIF6
Gene Name
KIF6
UniProt ID
Q6ZMV9
Defining Change(s)
C Allelers20455
Allele Name
Not Available
Genotype(s)
(C;C) / (C;T)
Type(s)
Effect Directly Studied
Groups
Not Available
Description
Patients with this genotype have a greater reduction in risk of a major cardiovascular event with high dose pravastatin.
References
  1. Iakoubova OA, Tong CH, Rowland CM, Kirchgessner TG, Young BA, Arellano AR, Shiffman D, Sabatine MS, Campos H, Packard CJ, Pfeffer MA, White TJ, Braunwald E, Shepherd J, Devlin JJ, Sacks FM: Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials. J Am Coll Cardiol. 2008 Jan 29;51(4):435-43. doi: 10.1016/j.jacc.2007.05.057. [PubMed:18222353]