Pharmacogenomic Effect/ADR for Pravastatin (DBSNPE000083)

Identifier
DBSNPE000083
Drug
Pravastatin (DB00175)
Interacting Gene/Enzyme
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Gene Name
HMGCR
UniProt ID
P04035
Defining Change(s)
T Allelers17244841
Allele Name
Not Available
Genotype(s)
(A;T)
Type(s)
Effect Directly Studied
Groups
Not Available
Description
Patients with this genotype have a lesser reduction in LDL cholesterol with pravastatin.
References
  1. Chasman DI, Posada D, Subrahmanyan L, Cook NR, Stanton VP Jr, Ridker PM: Pharmacogenetic study of statin therapy and cholesterol reduction. JAMA. 2004 Jun 16;291(23):2821-7. [PubMed:15199031]