Pharmacogenomic Effect/ADR for Irinotecan (DBSNPE000120)

Identifier
DBSNPE000120
Drug
Irinotecan (DB00762)
Interacting Gene/Enzyme
UDP-glucuronosyltransferase 1-1
Gene Name
UGT1A1
UniProt ID
P22309
Defining Change(s)
A Allelers10929302
Allele Name
UGT1A1*93
Genotype(s)
(A;A) / (A;G)
Type(s)
ADR Directly Studied
Groups
Not Available
Description
The presence of this genotype in UGT1A1 may indicate an increased risk of bone marrow toxicity when treated with irinotecan.
References
  1. Cote JF, Kirzin S, Kramar A, Mosnier JF, Diebold MD, Soubeyran I, Thirouard AS, Selves J, Laurent-Puig P, Ychou M: UGT1A1 polymorphism can predict hematologic toxicity in patients treated with irinotecan. Clin Cancer Res. 2007 Jun 1;13(11):3269-75. Epub 2007 May 17. [PubMed:17510208]