- Identifier
- DBSNPE000125
- Drug
- Theophylline (DB00277)
- Interacting Gene/Enzyme
- Cytochrome P450 1A2
- Gene Name
- CYP1A2
- UniProt ID
- P05177
- Defining Change(s)
- Allele Name
- -2964(G/A)
- Genotype(s)
- (A;A) / (G;A)
- Type(s)
- Effect Directly Studied
- Groups
- Not Available
- Description
- Patients with this genotype have reduced metabolism of theophylline.
- References
- Obase Y, Shimoda T, Kawano T, Saeki S, Tomari SY, Mitsuta-Izaki K, Matsuse H, Kinoshita M, Kohno S: Polymorphisms in the CYP1A2 gene and theophylline metabolism in patients with asthma. Clin Pharmacol Ther. 2003 May;73(5):468-74. [PubMed:12732846]