Pharmacogenomic Effect/ADR for Theophylline (DBSNPE000125)

Identifier
DBSNPE000125
Drug
Theophylline (DB00277)
Interacting Gene/Enzyme
Cytochrome P450 1A2
Gene Name
CYP1A2
UniProt ID
P05177
Defining Change(s)
A AlleleNot Available
Allele Name
-2964(G/A)
Genotype(s)
(A;A) / (G;A)
Type(s)
Effect Directly Studied
Groups
Not Available
Description
Patients with this genotype have reduced metabolism of theophylline.
References
  1. Obase Y, Shimoda T, Kawano T, Saeki S, Tomari SY, Mitsuta-Izaki K, Matsuse H, Kinoshita M, Kohno S: Polymorphisms in the CYP1A2 gene and theophylline metabolism in patients with asthma. Clin Pharmacol Ther. 2003 May;73(5):468-74. [PubMed:12732846]