Pharmacogenomic Effect/ADR for Tacrolimus (DBSNPE000126)

Identifier
DBSNPE000126
Drug
Tacrolimus (DB00864)
Interacting Gene/Enzyme
Multidrug resistance protein 1
Gene Name
ABCB1
UniProt ID
P08183
Defining Change(s)
T Allele (G2677T)rs2032582
Allele Name
Not Available
Genotype(s)
(G;T) / (T;T)
Type(s)
ADR Directly Studied
Groups
Not Available
Description
The presence of this genotype in ABCB1 may indicate an increased risk of drug-induced neurotoxicity when treated with tacrolimus.
References
  1. Yamauchi A, Ieiri I, Kataoka Y, Tanabe M, Nishizaki T, Oishi R, Higuchi S, Otsubo K, Sugimachi K: Neurotoxicity induced by tacrolimus after liver transplantation: relation to genetic polymorphisms of the ABCB1 (MDR1) gene. Transplantation. 2002 Aug 27;74(4):571-2. [PubMed:12352921]