Pharmacogenomic Effect/ADR for Amitriptyline (DBSNPE000131)

Identifier
DBSNPE000131
Drug
Amitriptyline (DB00321)
Interacting Gene/Enzyme
Cytochrome P450 2C19
Gene Name
CYP2C19
UniProt ID
P33261
Defining Change(s)
G > Ars4244285
Allele Name
CYP2C19*2
Genotype(s)
(A;A) / (A;G)
Type(s)
Directly Studied Effect
Groups
Non-functional CYP2C19
Description
Patients with this genotype have reduced metabolism of amitriptyline.
References
  1. de Vos A, van der Weide J, Loovers HM: Association between CYP2C19*17 and metabolism of amitriptyline, citalopram and clomipramine in Dutch hospitalized patients. Pharmacogenomics J. 2011 Oct;11(5):359-67. doi: 10.1038/tpj.2010.39. Epub 2010 Jun 8. [PubMed:20531370]