Pharmacogenomic Effect/ADR for Clobazam (DBSNPE000133)

Identifier
DBSNPE000133
Drug
Clobazam (DB00349)
Interacting Gene/Enzyme
Cytochrome P450 2C19
Gene Name
CYP2C19
UniProt ID
P33261
Defining Change(s)
G > A/Crs4244285
Allele Name
CYP2C19*2
Genotype(s)
(A;A) / (A;G)
Type(s)
ADR Directly Studied
Groups
Non-functional CYP2C19
Description
Patients with this genotype have reduced metabolism of clobazam.
References
  1. Giraud C, Tran A, Rey E, Vincent J, Treluyer JM, Pons G: In vitro characterization of clobazam metabolism by recombinant cytochrome P450 enzymes: importance of CYP2C19. Drug Metab Dispos. 2004 Nov;32(11):1279-86. [PubMed:15483195]