Pharmacogenomic Effect/ADR for Gefitinib (DBSNPE000138)

Identifier
DBSNPE000138
Drug
Gefitinib (DB00317)
Interacting Gene/Enzyme
ATP-binding cassette sub-family G member 2
Gene Name
ABCG2
UniProt ID
Q9UNQ0
Defining Change(s)
A allelers2231142
Allele Name
Not Available
Genotype(s)
(A;C)
Type(s)
ADR Directly Studied
Groups
Not Available
Description
Patients with this genotype have an increased risk of diarrhea with gefitinib.
References
  1. Cusatis G, Gregorc V, Li J, Spreafico A, Ingersoll RG, Verweij J, Ludovini V, Villa E, Hidalgo M, Sparreboom A, Baker SD: Pharmacogenetics of ABCG2 and adverse reactions to gefitinib. J Natl Cancer Inst. 2006 Dec 6;98(23):1739-42. [PubMed:17148776]