Pharmacogenomic Effect/ADR for Acetylsalicylic acid (DBSNPE000150)

Identifier
DBSNPE000150
Drug
Acetylsalicylic acid (DB00945)
Interacting Gene/Enzyme
Integrin beta-3
Gene Name
ITGB3
UniProt ID
P05106
Defining Change(s)
T > Crs5918
Allele Name
GPIIIa PlA2
Genotype(s)
(C;C) / (C;T)
Type(s)
Effect Directly Studied
Groups
Not Available
Description
Patients with this genotype have increased resistance to the anti-thrombotic effects of aspirin.
References
  1. Undas A, Brummel K, Musial J, Mann KG, Szczeklik A: Pl(A2) polymorphism of beta(3) integrins is associated with enhanced thrombin generation and impaired antithrombotic action of aspirin at the site of microvascular injury. Circulation. 2001 Nov 27;104(22):2666-72. [PubMed:11723016]